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Entry version 143 (17 Jun 2020)
Sequence version 2 (02 May 2006)
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Protein

C-Jun-amino-terminal kinase-interacting protein 4

Gene

Spag9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12391307, PubMed:15767678). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-525793 Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-Jun-amino-terminal kinase-interacting protein 4
Short name:
JIP-4
Short name:
JNK-interacting protein 4
Alternative name(s):
JNK-associated leucine-zipper protein
Short name:
JLP
JNK/SAPK-associated protein 2
Short name:
JSAP2
Mitogen-activated protein kinase 8-interacting protein 4
Sperm-associated antigen 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spag9
Synonyms:Jip4, Jsap2, Kiaa0516, Mapk8ip4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918084 Spag9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340771 – 1321C-Jun-amino-terminal kinase-interacting protein 4Add BLAST1321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei109PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei185PhosphoserineBy similarity1
Modified residuei194PhosphoserineBy similarity1
Modified residuei203PhosphoserineCombined sources1
Modified residuei217PhosphothreonineCombined sources1
Modified residuei238PhosphoserineBy similarity1
Modified residuei251PhosphoserineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei292PhosphothreonineCombined sources1
Modified residuei311PhosphoserineBy similarity1
Modified residuei329PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei348PhosphothreonineBy similarity1
Modified residuei365PhosphothreonineCombined sources1
Modified residuei418PhosphothreonineBy similarity1
Modified residuei586PhosphothreonineBy similarity1
Modified residuei588PhosphoserineBy similarity1
Modified residuei595PhosphothreonineBy similarity1
Modified residuei705PhosphoserineBy similarity1
Modified residuei728PhosphoserineBy similarity1
Modified residuei730PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei733PhosphoserineCombined sources1
Modified residuei1188PhosphoserineBy similarity1
Modified residuei1264PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAPK8 and MAPK14.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q58A65

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q58A65

PeptideAtlas

More...
PeptideAtlasi
Q58A65

PRoteomics IDEntifications database

More...
PRIDEi
Q58A65

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q58A65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q58A65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 6 is highly expressed in brain, kidney, liver, heart.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during neuronal differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020859 Expressed in utricle of membranous labyrinth and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q58A65 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q58A65 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). The homodimer interacts with ARF6, forming a heterotetramer (By similarity). Homooligomer (By similarity).

Interacts with MAX, MAPK8, MAPK14, MAP3K3, MYC, and MAP2K4 (PubMed:12391307).

Interacts with KNS2 (PubMed:15987681). Interaction with KNS2 is important in the formation of ternary complex with MAPK8 (PubMed:15767678).

Interacts with PIP4P1 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
214283, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q58A65, 3 interactors

Molecular INTeraction database

More...
MINTi
Q58A65

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000042271

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q58A65 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 95RH1PROSITE-ProRule annotationAdd BLAST89
Domaini500 – 604RH2PROSITE-ProRule annotationAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili66 – 166Sequence analysisAdd BLAST101
Coiled coili408 – 534By similarityAdd BLAST127
Coiled coili724 – 758Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JIP scaffold family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2077 Eukaryota
ENOG410XQ19 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153496

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q58A65

KEGG Orthology (KO)

More...
KOi
K20317

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFVAVPX

Database of Orthologous Groups

More...
OrthoDBi
324912at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q58A65

TreeFam database of animal gene trees

More...
TreeFami
TF313096

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13886 PTHR13886, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q58A65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELEDGVVYQ EEPGGSGAVM SERVSGLAGS IYREFERLIG RYDEEVVKEL
60 70 80 90 100
MPLVVAVLEN LDSVFAQDQE HQVELELLRD DNEQLITQYE REKALRKHAE
110 120 130 140 150
EKFIEFEDSQ EQEKKDLQTR VESLESQTRQ LELKAKNYAD QISRLEEREA
160 170 180 190 200
ELKKEYNALH QRHTEMIHNY MEHLERTKLH QLSGSDQLEA TAHSRIRKER
210 220 230 240 250
PISLGIFPLP AGDGLLTPDT QKGGETPGSE QWKFQELSQP RSHTSLKVSH
260 270 280 290 300
SPEPPKAVEQ EDELSDISQG GSKATTPAST ANSDVSAIPP DTPSKEDNEG
310 320 330 340 350
FVKGTDTSNK SEISKHIEVQ VAQETRNVST ESGENEEKSE VQAIIESTPE
360 370 380 390 400
LDMDKDLSGY KGSSTPTKGI ENKAFDRNTE SLFEELSSAG SGLIGDVDEG
410 420 430 440 450
ADLLGMGREV ENLILENTQL LETKNALNVV KNDLIAKVDE LTCEKDVLQG
460 470 480 490 500
ELEAVKQAKL KLEDKNRELE EELRKARAEA EDARQKAKDD DDSDIPTAQR
510 520 530 540 550
KRFTRVEMAR VLMERNQYKE RLMELQEAVR WTEMIRASRE NPAMQEKKRS
560 570 580 590 600
SIWQFFSRLF SSSSNATKKP EPPVNLKYNA PTSHVTPSVK KRSSTLSQLP
610 620 630 640 650
GDKSKAFDFL SEETEASLAS RREQKREQYR QVKAHVQKED GRVQAFGWSL
660 670 680 690 700
PQKYKQVANG QGETKMKNLP VPVYLRPLDE KDASMKLWCA VGVNLSGGKT
710 720 730 740 750
RDGGSVVGAS VFYKDIAGLD TEGSKQRSAS QSSLDKLDQE LKEQQKEFKN
760 770 780 790 800
QEELSSQVWI CTSTHSTTKV IIIDAVQPGN ILDSFTVCNS HVLCIASVPG
810 820 830 840 850
ARETDYPAGE ELSESGQVDK ASLCGSMTSN SSAEMDSLLG GITVVGCSTE
860 870 880 890 900
GLTGAATSPS TNGASPVIEK PPEMETENSE VDENIPTAEE ATEATEGNAG
910 920 930 940 950
STEDTVDISQ PGVYTEHVFT DPLGVQIPED LSPVFQSSND SDVYKDQISV
960 970 980 990 1000
LPNEQDLARE EAQKMSSLLP TMWLGAQNGC LYVHSSVAQW RKCLHSIKLK
1010 1020 1030 1040 1050
DSILSIVHVK GIVLVALADG TLAIFHRGVD GQWDLSNYHL LDLGRPHHSI
1060 1070 1080 1090 1100
RCMTVVHDKV WCGYRNKIYV VQPKAMKIEK SFDAHPRKES QVRQLAWVGD
1110 1120 1130 1140 1150
GVWVSIRLDS TLRLYHAHTY QHLQDVDIEP YVSKMLGTGK LGFSFVRITA
1160 1170 1180 1190 1200
LMVSCNRLWV GTGNGVIISI PLTETNKTSG TPGNRPGSVI RVYGDENSDK
1210 1220 1230 1240 1250
VTPGTFIPYC SMAHAQLCFH GHRDAVKFFV AVPGQVISPQ SSSGGADLTA
1260 1270 1280 1290 1300
DKAGSSAQEP SSQTPLKSML VISGGEGYID FRMGDEGGES ELLGEDLPLE
1310 1320
PSVTKAERSH LIVWQVMCGN E
Length:1,321
Mass (Da):146,219
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93A6E97A62E0E92C
GO
Isoform 2 (identifier: Q58A65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-261: Missing.

Show »
Length:1,307
Mass (Da):144,704
Checksum:i8C99195A5AFFC7BF
GO
Isoform 3 (identifier: Q58A65-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.
     144-196: RLEEREAELK...QLEATAHSRI → MNPGCMLLFV...ALTQNLPRIL
     248-261: Missing.
     405-405: G → GEYSG

Show »
Length:1,168
Mass (Da):127,680
Checksum:i34B7E6B2D81B7DF9
GO
Isoform 4 (identifier: Q58A65-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.
     144-196: RLEEREAELK...QLEATAHSRI → MNPGCMLLFV...ALTQNLPRIL
     248-261: Missing.
     1175-1175: T → TVILHQGRLLGLRA

Show »
Length:1,177
Mass (Da):128,672
Checksum:i730D991D29C5A74B
GO
Isoform 5 (identifier: Q58A65-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-196: RLEEREAELK...QLEATAHSRI → MNPGCMLLFV...ALTQNLPRIL
     248-261: Missing.

Show »
Length:1,307
Mass (Da):143,835
Checksum:iF186D445467EE5B6
GO
Isoform 6 (identifier: Q58A65-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.
     248-261: Missing.

Show »
Length:1,142
Mass (Da):125,350
Checksum:i16184E1CE2BF26A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUD1E9PUD1_MOUSE
C-Jun-amino-terminal kinase-interac...
Spag9
1,169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J196A0A0R4J196_MOUSE
C-Jun-amino-terminal kinase-interac...
Spag9
1,164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WH31F8WH31_MOUSE
C-Jun-amino-terminal kinase-interac...
Spag9
1,169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WNT4F6WNT4_MOUSE
C-Jun-amino-terminal kinase-interac...
Spag9
706Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SH61F6SH61_MOUSE
C-Jun-amino-terminal kinase-interac...
Spag9
775Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YMB8Z4YMB8_MOUSE
C-Jun-amino-terminal kinase-interac...
Spag9
901Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32239 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI35376 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241R → C in AAN61564 (PubMed:12391307).Curated1
Sequence conflicti453E → A in AAN61564 (PubMed:12391307).Curated1
Sequence conflicti468E → G in BAE27980 (PubMed:16141072).Curated1
Sequence conflicti705S → T in BAD93176 (Ref. 3) Curated1
Sequence conflicti1114L → P in BAE27907 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0182251 – 165Missing in isoform 6. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_0182261 – 143Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST143
Alternative sequenceiVSP_018227144 – 196RLEER…AHSRI → MNPGCMLLFVFGFVGGAVVI NSAILVSLSVLLLVHFSIST GVPALTQNLPRIL in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST53
Alternative sequenceiVSP_018228248 – 261Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 5 PublicationsAdd BLAST14
Alternative sequenceiVSP_018229405G → GEYSG in isoform 3. 1 Publication1
Alternative sequenceiVSP_0182301175T → TVILHQGRLLGLRA in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF327451 mRNA Translation: AAN61564.1
AY823270 mRNA Translation: AAX19462.1
AB047782 mRNA Translation: BAD93176.1
AK172961 mRNA Translation: BAD32239.1 Different initiation.
AK147431 mRNA Translation: BAE27907.1
AK147537 mRNA Translation: BAE27980.1
AL662838 Genomic DNA Translation: CAI35367.1
AL662838 Genomic DNA Translation: CAI35375.1
AL662838 Genomic DNA Translation: CAI35376.1 Sequence problems.
BC060100 mRNA Translation: AAH60100.1
BC094670 mRNA Translation: AAH94670.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25248.1 [Q58A65-2]
CCDS56797.1 [Q58A65-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001020599.1, NM_001025428.1
NP_001020600.1, NM_001025429.1 [Q58A65-3]
NP_001020601.1, NM_001025430.1
NP_001186132.1, NM_001199203.1
NP_001186133.1, NM_001199204.1
NP_001186134.1, NM_001199205.1 [Q58A65-4]
NP_081845.2, NM_027569.2 [Q58A65-2]
XP_006534282.1, XM_006534219.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000041956; ENSMUSP00000042271; ENSMUSG00000020859 [Q58A65-2]
ENSMUST00000075695; ENSMUSP00000075115; ENSMUSG00000020859 [Q58A65-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:70834

UCSC genome browser

More...
UCSCi
uc007kxx.1 mouse [Q58A65-2]
uc007kxy.1 mouse [Q58A65-1]
uc007kxz.1 mouse [Q58A65-6]
uc007kya.1 mouse [Q58A65-3]
uc007kyc.1 mouse [Q58A65-5]
uc007kyd.1 mouse [Q58A65-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327451 mRNA Translation: AAN61564.1
AY823270 mRNA Translation: AAX19462.1
AB047782 mRNA Translation: BAD93176.1
AK172961 mRNA Translation: BAD32239.1 Different initiation.
AK147431 mRNA Translation: BAE27907.1
AK147537 mRNA Translation: BAE27980.1
AL662838 Genomic DNA Translation: CAI35367.1
AL662838 Genomic DNA Translation: CAI35375.1
AL662838 Genomic DNA Translation: CAI35376.1 Sequence problems.
BC060100 mRNA Translation: AAH60100.1
BC094670 mRNA Translation: AAH94670.1
CCDSiCCDS25248.1 [Q58A65-2]
CCDS56797.1 [Q58A65-3]
RefSeqiNP_001020599.1, NM_001025428.1
NP_001020600.1, NM_001025429.1 [Q58A65-3]
NP_001020601.1, NM_001025430.1
NP_001186132.1, NM_001199203.1
NP_001186133.1, NM_001199204.1
NP_001186134.1, NM_001199205.1 [Q58A65-4]
NP_081845.2, NM_027569.2 [Q58A65-2]
XP_006534282.1, XM_006534219.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi214283, 5 interactors
IntActiQ58A65, 3 interactors
MINTiQ58A65
STRINGi10090.ENSMUSP00000042271

PTM databases

iPTMnetiQ58A65
PhosphoSitePlusiQ58A65

Proteomic databases

jPOSTiQ58A65
PaxDbiQ58A65
PeptideAtlasiQ58A65
PRIDEiQ58A65

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30731 200 antibodies

Genome annotation databases

EnsembliENSMUST00000041956; ENSMUSP00000042271; ENSMUSG00000020859 [Q58A65-2]
ENSMUST00000075695; ENSMUSP00000075115; ENSMUSG00000020859 [Q58A65-3]
GeneIDi70834
KEGGimmu:70834
UCSCiuc007kxx.1 mouse [Q58A65-2]
uc007kxy.1 mouse [Q58A65-1]
uc007kxz.1 mouse [Q58A65-6]
uc007kya.1 mouse [Q58A65-3]
uc007kyc.1 mouse [Q58A65-5]
uc007kyd.1 mouse [Q58A65-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9043
MGIiMGI:1918084 Spag9

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2077 Eukaryota
ENOG410XQ19 LUCA
GeneTreeiENSGT00940000153496
InParanoidiQ58A65
KOiK20317
OMAiFFVAVPX
OrthoDBi324912at2759
PhylomeDBiQ58A65
TreeFamiTF313096

Enzyme and pathway databases

ReactomeiR-MMU-525793 Myogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
70834 2 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Spag9 mouse

Protein Ontology

More...
PROi
PR:Q58A65
RNActiQ58A65 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020859 Expressed in utricle of membranous labyrinth and 248 other tissues
ExpressionAtlasiQ58A65 baseline and differential
GenevisibleiQ58A65 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13886 PTHR13886, 1 hit
PfamiView protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJIP4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q58A65
Secondary accession number(s): Q3UH77
, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: June 17, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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