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Protein

PAN2-PAN3 deadenylation complex subunit PAN3

Gene

PAN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.UniRule annotation2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei521ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri43 – 71C3H1-typeUniRule annotationAdd BLAST29
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi570 – 577ATPUniRule annotation8
Nucleotide bindingi644 – 645ATPUniRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-429947 Deadenylation of mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PAN2-PAN3 deadenylation complex subunit PAN3UniRule annotation
Alternative name(s):
PAB1P-dependent poly(A)-specific ribonucleaseUniRule annotation
Poly(A)-nuclease deadenylation complex subunit 3UniRule annotation
Short name:
PAN deadenylation complex subunit 3UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAN3UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152520.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29991 PAN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617448 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q58A45

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi203Y → A: Reduces interaction with polyadenylate-binding protein. 1 Publication1
Mutagenesisi293F → A: Reduces interaction with polyadenylate-binding protein. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
255967

Open Targets

More...
OpenTargetsi
ENSG00000152520

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596398

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
341942213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002805251 – 887PAN2-PAN3 deadenylation complex subunit PAN3Add BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei354PhosphoserineCombined sources1
Modified residuei361PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q58A45

MaxQB - The MaxQuant DataBase

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MaxQBi
Q58A45

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q58A45

PeptideAtlas

More...
PeptideAtlasi
Q58A45

PRoteomics IDEntifications database

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PRIDEi
Q58A45

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62604
62605 [Q58A45-2]
62606 [Q58A45-3]
62607 [Q58A45-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q58A45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q58A45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152520 Expressed in 209 organ(s), highest expression level in oviduct epithelium

CleanEx database of gene expression profiles

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CleanExi
HS_PAN3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q58A45 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028817

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.UniRule annotation5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129129, 16 interactors

Database of interacting proteins

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DIPi
DIP-53755N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q58A45

Protein interaction database and analysis system

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IntActi
Q58A45, 9 interactors

Molecular INTeraction database

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MINTi
Q58A45

STRING: functional protein association networks

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STRINGi
9606.ENSP00000370345

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q58A45

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q58A45

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni463 – 750Pseudokinase domainUniRule annotationAdd BLAST288
Regioni790 – 887Knob domainUniRule annotationAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili751 – 789UniRule annotationAdd BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi284 – 299PABPC-interacting motif-2 (PAM-2)UniRule annotation1 PublicationAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal zinc finger binds to poly(A) RNA.UniRule annotation
Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.UniRule annotation
The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.UniRule annotation2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. PAN3 family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 71C3H1-typeUniRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3741 Eukaryota
ENOG410XQ42 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001504

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG058849

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q58A45

KEGG Orthology (KO)

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KOi
K12572

Identification of Orthologs from Complete Genome Data

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OMAi
DSYFTKR

Database of Orthologous Groups

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OrthoDBi
EOG091G04WA

Database for complete collections of gene phylogenies

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PhylomeDBi
Q58A45

TreeFam database of animal gene trees

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TreeFami
TF105865

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03181 PAN3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR030844 PAN3
IPR000719 Prot_kinase_dom
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

The PANTHER Classification System

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PANTHERi
PTHR12272 PTHR12272, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356 ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q58A45-1) [UniParc]FASTAAdd to basket
Also known as: Pan3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSGGGLPPP SAAASPSSSS LAAAVAVVAP PGVGGVPGGA AVGVKLKYCR
60 70 80 90 100
YYAKDKTCFY GEECQFLHED PAAGAAPGLG LHSNSVPLAL AGAPVAGFPP
110 120 130 140 150
GAVAGGGAGP PPGPKKPDLG DPGTGAAAGG GGSSGGLDGP RLAIPGMDGG
160 170 180 190 200
ALTDTSLTDS YFSTSFIGVN GFGSPVETKY PLMQRMTNSS SSPSLLNDSA
210 220 230 240 250
KPYSAHDPLT SPASSLFNDF GALNISQRRK PRKYRLGMLE ERLVPMGSKA
260 270 280 290 300
RKAKNPIGCL ADRCKSGVPI NMVWWNRVTE NNLQTPNPTA SEFIPKGGST
310 320 330 340 350
SRLSNVSQSN MSAFSQVFSH PSMGSPATAG LAPGMSLSAG SSPLHSPKIT
360 370 380 390 400
PHTSPAPRRR SHTPNPASYM VPSSASTSVN NPVSQTPSSG QVIQKETVGG
410 420 430 440 450
TTYFYTDTTP APLTGMVFPN YHIYPPTAPH VAYMQPKANA PSFFMADELR
460 470 480 490 500
QELINRHLIT MAQIDQADMP AVPTEVDSYH SLFPLEPLPP PNRIQKSSNF
510 520 530 540 550
GYITSCYKAV NSKDDLPYCL RRIHGFRLVN TKCMVLVDMW KKIQHSNIVT
560 570 580 590 600
LREVFTTKAF AEPSLVFAYD FHAGGETMMS RHFNDPNADA YFTKRKWGQH
610 620 630 640 650
EGPLPRQHAG LLPESLIWAY IVQLSSALRT IHTAGLACRV MDPTKILITG
660 670 680 690 700
KTRLRVNCVG VFDVLTFDNS QNNNPLALMA QYQQADLISL GKVVLALACN
710 720 730 740 750
SLAGIQRENL QKAMELVTIN YSSDLKNLIL YLLTDQNRMR SVNDIMPMIG
760 770 780 790 800
ARFYTQLDAA QMRNDVIEED LAKEVQNGRL FRLLAKLGTI NERPEFQKDP
810 820 830 840 850
TWSETGDRYL LKLFRDHLFH QVTEAGAPWI DLSHIISCLN KLDAGVPEKI
860 870 880
SLISRDEKSV LVVTYSDLKR CFENTFQELI AAANGQL
Length:887
Mass (Da):95,613
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4883F859D2A642D2
GO
Isoform 2 (identifier: Q58A45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     333-333: P → MKLTDSTKGWIVWAALDSSMR

Show »
Length:575
Mass (Da):64,465
Checksum:i8FF7B393A072FD8D
GO
Isoform 3 (identifier: Q58A45-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-284: Missing.

Show »
Length:833
Mass (Da):89,405
Checksum:i06EAD23E1B205A4F
GO
Isoform 4 (identifier: Q58A45-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     684-687: QADL → VSKN
     688-887: Missing.

Show »
Length:687
Mass (Da):72,933
Checksum:iC3AFEB0807CE9F3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFZ9A0A0C4DFZ9_HUMAN
PAN2-PAN3 deadenylation complex sub...
PAN3
687Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI28180 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence ABK41888 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC03632 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229R → Q in BAD02262 (PubMed:14583602).Curated1
Sequence conflicti569Y → H in AAI28181 (PubMed:15489334).Curated1
Sequence conflicti793R → G in BAC03632 (PubMed:14702039).Curated1
Sequence conflicti856D → G in BAD02262 (PubMed:14583602).Curated1
Sequence conflicti856D → G in BAD93184 (PubMed:14583602).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0237531 – 332Missing in isoform 2. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_023754231 – 284Missing in isoform 3. 2 PublicationsAdd BLAST54
Alternative sequenceiVSP_023755333P → MKLTDSTKGWIVWAALDSSM R in isoform 2. 1 Publication1
Alternative sequenceiVSP_041648684 – 687QADL → VSKN in isoform 4. 1 Publication4
Alternative sequenceiVSP_041649688 – 887Missing in isoform 4. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK091307 mRNA Translation: BAC03632.1 Different initiation.
AK296435 mRNA Translation: BAH12353.1
EF088216 Genomic DNA Translation: ABK41888.1 Sequence problems.
AL138712 Genomic DNA No translation available.
AL356915 Genomic DNA No translation available.
BC024318 mRNA Translation: AAH24318.1
BC128179 mRNA Translation: AAI28180.1 Different initiation.
BC128180 mRNA Translation: AAI28181.1
AB107584 mRNA Translation: BAD02262.1
AB109552 mRNA Translation: BAD93184.1
BX647740 mRNA Translation: CAI45987.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS9329.2 [Q58A45-1]

NCBI Reference Sequences

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RefSeqi
NP_787050.6, NM_175854.7 [Q58A45-1]
XP_005266390.1, XM_005266333.3 [Q58A45-3]
XP_005266391.1, XM_005266334.1 [Q58A45-2]
XP_016876021.1, XM_017020532.1 [Q58A45-2]
XP_016876022.1, XM_017020533.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.645015

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000380958; ENSP00000370345; ENSG00000152520 [Q58A45-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
255967

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:255967

UCSC genome browser

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UCSCi
uc001urz.4 human [Q58A45-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091307 mRNA Translation: BAC03632.1 Different initiation.
AK296435 mRNA Translation: BAH12353.1
EF088216 Genomic DNA Translation: ABK41888.1 Sequence problems.
AL138712 Genomic DNA No translation available.
AL356915 Genomic DNA No translation available.
BC024318 mRNA Translation: AAH24318.1
BC128179 mRNA Translation: AAI28180.1 Different initiation.
BC128180 mRNA Translation: AAI28181.1
AB107584 mRNA Translation: BAD02262.1
AB109552 mRNA Translation: BAD93184.1
BX647740 mRNA Translation: CAI45987.2
CCDSiCCDS9329.2 [Q58A45-1]
RefSeqiNP_787050.6, NM_175854.7 [Q58A45-1]
XP_005266390.1, XM_005266333.3 [Q58A45-3]
XP_005266391.1, XM_005266334.1 [Q58A45-2]
XP_016876021.1, XM_017020532.1 [Q58A45-2]
XP_016876022.1, XM_017020533.1
UniGeneiHs.645015

3D structure databases

ProteinModelPortaliQ58A45
SMRiQ58A45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129129, 16 interactors
DIPiDIP-53755N
ELMiQ58A45
IntActiQ58A45, 9 interactors
MINTiQ58A45
STRINGi9606.ENSP00000370345

PTM databases

iPTMnetiQ58A45
PhosphoSitePlusiQ58A45

Polymorphism and mutation databases

BioMutaiPAN3
DMDMi341942213

Proteomic databases

EPDiQ58A45
MaxQBiQ58A45
PaxDbiQ58A45
PeptideAtlasiQ58A45
PRIDEiQ58A45
ProteomicsDBi62604
62605 [Q58A45-2]
62606 [Q58A45-3]
62607 [Q58A45-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380958; ENSP00000370345; ENSG00000152520 [Q58A45-1]
GeneIDi255967
KEGGihsa:255967
UCSCiuc001urz.4 human [Q58A45-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
255967
DisGeNETi255967
EuPathDBiHostDB:ENSG00000152520.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PAN3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0011200
HGNCiHGNC:29991 PAN3
HPAiHPA028817
MIMi617448 gene
neXtProtiNX_Q58A45
OpenTargetsiENSG00000152520
PharmGKBiPA144596398

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3741 Eukaryota
ENOG410XQ42 LUCA
GeneTreeiENSGT00390000001504
HOVERGENiHBG058849
InParanoidiQ58A45
KOiK12572
OMAiDSYFTKR
OrthoDBiEOG091G04WA
PhylomeDBiQ58A45
TreeFamiTF105865

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PAN3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
255967

Protein Ontology

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PROi
PR:Q58A45

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152520 Expressed in 209 organ(s), highest expression level in oviduct epithelium
CleanExiHS_PAN3
ExpressionAtlasiQ58A45 baseline and differential

Family and domain databases

HAMAPiMF_03181 PAN3, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR030844 PAN3
IPR000719 Prot_kinase_dom
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PANTHERiPTHR12272 PTHR12272, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAN3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q58A45
Secondary accession number(s): A0N0X1
, A1A4Y8, A1A4Y9, B1ALF1, B7Z3W7, Q0D2P2, Q5HYG6, Q5T515, Q5T516, Q5TBA0, Q76E13, Q8NBA6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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