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Protein

Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase

Gene

MJ1585

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transaldolisation of either fructose-1-P or fructose-1,6-bisphosphate with methylglyoxal to produce 6-deoxy-5-ketofructose-1-phosphate (DKFP). Also catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P or GAP) to produce fructose 1,6-bisphosphate (FBP).1 Publication

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.1 Publication
2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate.1 Publication
2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate.1 Publication

Pathwayi: Aromatic compound metabolism

This protein is involved in Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateBy similarity1
Binding sitei57SubstrateBy similarity1
Binding sitei180SubstrateBy similarity1
Active sitei182Proton donorBy similarity1
Binding sitei184SubstrateBy similarity1
Active sitei213Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Active sitei213Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionLyase, Transferase
LigandSchiff base

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14590
BRENDAi2.2.1.11 3260

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase (EC:2.2.1.111 Publication, EC:4.1.2.131 Publication)
Alternative name(s):
DKFP synthase
Fructose-bisphosphate aldolase class 1
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Ordered Locus Names:MJ1585
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001389581 – 310Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthaseAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1585

Structurei

3D structure databases

ProteinModelPortaliQ58980
SMRiQ58980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 49Substrate bindingBy similarity2
Regioni213 – 215Substrate bindingBy similarity3
Regioni241 – 243Substrate bindingBy similarity3
Regioni270 – 271Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family.Curated

Phylogenomic databases

eggNOGiarCOG04044 Archaea
COG1830 LUCA
InParanoidiQ58980
KOiK16305
OMAiFVKVNYP
OrthoDBiPOG093Z070T
PhylomeDBiQ58980

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002915 DeoC/FbaB/lacD_aldolase
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF038992 Aldolase_Ia, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit

Sequencei

Sequence statusi: Complete.

Q58980-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIFMIKRLK KRDVKVPLTV PEDRKEEYIK NYLELTKRTG NVMLFAGDQK
60 70 80 90 100
IEHLNDDFFG EGIAKDDASP EHLFNIASKG KICGFATQLG LIARYGMDYK
110 120 130 140 150
KIPYIVKINS KTHLVKTRDP ISRALVHVKD VVDLKENSGL KILGVGYTIY
160 170 180 190 200
PGSEYEHIMF EEASRVILEA HKHGLIAIIW SYPRGKNVKD EKDPHLIAGA
210 220 230 240 250
AGVAACLGAD FVKVNYPKCD NPAERFKEAV LAAGRTGVLC AGGKSIEPEK
260 270 280 290 300
FLKQIWEQIN ISGARGNATG RNIHQKPLDA AIRMCNAIYA ITIEGKSLEE
310
ALKIYYGDRK
Length:310
Mass (Da):34,574
Last modified:November 1, 1996 - v1
Checksum:i4AB6286F888049C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99604.1
PIRiH64497

Genome annotation databases

EnsemblBacteriaiAAB99604; AAB99604; MJ_1585
KEGGimja:MJ_1585

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99604.1
PIRiH64497

3D structure databases

ProteinModelPortaliQ58980
SMRiQ58980
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1585

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99604; AAB99604; MJ_1585
KEGGimja:MJ_1585

Phylogenomic databases

eggNOGiarCOG04044 Archaea
COG1830 LUCA
InParanoidiQ58980
KOiK16305
OMAiFVKVNYP
OrthoDBiPOG093Z070T
PhylomeDBiQ58980

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14590
BRENDAi2.2.1.11 3260

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002915 DeoC/FbaB/lacD_aldolase
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF038992 Aldolase_Ia, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDKFP_METJA
AccessioniPrimary (citable) accession number: Q58980
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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