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UniProtKB - Q58905 (TYW3_METJA)
Protein
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
Gene
taw3
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Functioni
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
UniRule annotationCatalytic activityi
- 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.282UniRule annotation
GO - Molecular functioni
- tRNA methyltransferase activity Source: GO_Central
GO - Biological processi
- tRNA methylation Source: GO_Central
- wybutosine biosynthetic process Source: InterPro
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | tRNA processing |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseUniRule annotation (EC:2.1.1.282UniRule annotation)Alternative name(s): tRNA wyosine derivatives biosynthesis protein Taw3UniRule annotation |
Gene namesi | Name:taw3UniRule annotation Ordered Locus Names:MJ1510 |
Organismi | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) |
Taxonomic identifieri | 243232 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000157093 | 1 – 193 | tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseAdd BLAST | 193 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TYW3 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
HOGENOMi | CLU_047426_2_0_2 |
InParanoidi | Q58905 |
OMAi | GKWHHYA |
OrthoDBi | 118297at2157 |
PhylomeDBi | Q58905 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
i Sequence
Sequence statusi: Complete.
Q58905-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGFLEDKKRT LMNLELAIRE GLVDEEIIPI LNKINEIDNY YTTSSCIGRV
60 70 80 90 100
GIMEIPKDKN PKLYSRWLGK WHHYASYDEL FNALKNKKEG YIVFVMNSPI
110 120 130 140 150
LHIACKDIES AKKMLELAIH SGLKASSIKS ISDKRVIVEI LTTYKVDTPI
160 170 180 190
GEDGEIFVDN NYLKFLLDYS NSKLKRAREI LMRWANRLDE LKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L77117 Genomic DNA Translation: AAB99529.1 |
PIRi | E64488 |
RefSeqi | WP_010871033.1, NC_000909.1 |
Genome annotation databases
EnsemblBacteriai | AAB99529; AAB99529; MJ_1510 |
GeneIDi | 1452417 |
KEGGi | mja:MJ_1510 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L77117 Genomic DNA Translation: AAB99529.1 |
PIRi | E64488 |
RefSeqi | WP_010871033.1, NC_000909.1 |
3D structure databases
AlphaFoldDBi | Q58905 |
SMRi | Q58905 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 243232.MJ_1510 |
Genome annotation databases
EnsemblBacteriai | AAB99529; AAB99529; MJ_1510 |
GeneIDi | 1452417 |
KEGGi | mja:MJ_1510 |
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
HOGENOMi | CLU_047426_2_0_2 |
InParanoidi | Q58905 |
OMAi | GKWHHYA |
OrthoDBi | 118297at2157 |
PhylomeDBi | Q58905 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TYW3_METJA | |
Accessioni | Q58905Primary (citable) accession number: Q58905 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - SIMILARITY comments
Index of protein domains and families