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Protein

Leptin

Gene

lep

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as part of a signaling pathway that acts to regulate the size of the body fat depot.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin
Gene namesi
Name:lep
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000004292827 – 152LeptinAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi109 ↔ 152By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed mostly in the liver.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the leptin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KHPN Eukaryota
ENOG4110R2G LUCA
GeneTreeiENSGT00530000066614
InParanoidiQ588G0
OMAiWPRRNIF
OrthoDBiEOG091G0ONC

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q588G0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHILALVLA LLPLSLCVAL PGALDAMDVE KMKSKVTWKA QGLVARIDKH
60 70 80 90 100
FPDRGLRFDT DKVEGSTSVV ASLESYNNLI SDRFGGVSQI KTEISSLAGY
110 120 130 140 150
LNHWREGNCQ EQQPKVWPRR NIFNHTVSLE ALMRVREFLK LLQKNVDLLE

RC
Length:152
Mass (Da):17,204
Last modified:May 10, 2005 - v1
Checksum:i4CE6B3227801A4B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB193547 mRNA Translation: BAD94444.1
RefSeqiNP_001027897.1, NM_001032725.1
UniGeneiTru.3499

Genome annotation databases

EnsembliENSTRUT00000034211; ENSTRUP00000034085; ENSTRUG00000013373
GeneIDi548631
KEGGitru:548631

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB193547 mRNA Translation: BAD94444.1
RefSeqiNP_001027897.1, NM_001032725.1
UniGeneiTru.3499

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTRUT00000034211; ENSTRUP00000034085; ENSTRUG00000013373
GeneIDi548631
KEGGitru:548631

Organism-specific databases

CTDi3952

Phylogenomic databases

eggNOGiENOG410KHPN Eukaryota
ENOG4110R2G LUCA
GeneTreeiENSGT00530000066614
InParanoidiQ588G0
OMAiWPRRNIF
OrthoDBiEOG091G0ONC

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLEP_TAKRU
AccessioniPrimary (citable) accession number: Q588G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 10, 2005
Last modified: January 31, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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