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Entry version 92 (02 Jun 2021)
Sequence version 1 (10 May 2005)
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Protein

DNA (cytosine-5-)-methyltransferase

Gene

dnmt3ba

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1231PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • DNA methylation Source: ZFIN
  • regulation of gene expression Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, MethyltransferasePROSITE-ProRule annotationARBA annotation, RepressorARBA annotation, Transferase
LigandMetal-binding, S-adenosyl-L-methioninePROSITE-ProRule annotationARBA annotation, Zinc

Protein family/group databases

Restriction enzymes and methylases database

More...
REBASEi
11770, M.DreLDnmt7P

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA (cytosine-5-)-methyltransferaseARBA annotation (EC:2.1.1.37ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnmt3baImported
Synonyms:dnmt3bImported, dnmt7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050314-4, dnmt3ba

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q588C3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 117Calponin-homology (CH)InterPro annotationAdd BLAST103
Domaini837 – 892PWWPInterPro annotationAdd BLAST56
Domaini1003 – 1135PHD-typeInterPro annotationAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni737 – 830DisorderedSequence analysisAdd BLAST94
Regioni958 – 978DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi746 – 760Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi762 – 779Polar residuesSequence analysisAdd BLAST18
Compositional biasi790 – 823Polar residuesSequence analysisAdd BLAST34
Compositional biasi958 – 976Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Zinc-fingerARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
TPYCVYV

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11728, ADDz_Dnmt3b, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025766, ADD
IPR018117, C5_DNA_meth_AS
IPR001525, C5_MeTfrase
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR040552, DNMT3_ADD
IPR030488, DNMT3B_ADD
IPR000313, PWWP_dom
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17980, ADD_DNMT3, 1 hit
PF00307, CH, 1 hit
PF00145, DNA_methylase, 1 hit
PF00855, PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00293, PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51533, ADD, 1 hit
PS00094, C5_MTASE_1, 1 hit
PS50021, CH, 1 hit
PS50812, PWWP, 1 hit
PS51679, SAM_MT_C5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q588C3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATNVSLEPN NPDDKCSRYE VLGWINETLQ TNFTQVEQCR SGACFCQLID
60 70 80 90 100
LLFPGTINLK KVKFESQKRS DFMQNYSLLQ AAFRDLEVTE PVPVNELLSG
110 120 130 140 150
KFRPNFTYLK WFKKFFYANV KQERVYNAFE ARDGQEIVPV DDVMKSPKAL
160 170 180 190 200
KSSYESGRAG EESDMEINGG RRSATYDPKW QRNLKWIRAS DMGDNYAYCT
210 220 230 240 250
TCDYNIILLA GFHDLKRHQL TQNHMKHETG RTNLPGRKQI EESISCSETM
260 270 280 290 300
LLFIQSHCLS SLPSRINRVS QRTARCILGL KYPNDIVSAC KLNPYCIYIY
310 320 330 340 350
GQVPLDVKTG DKTNCHVVLA GFFEEKQARY CIRFLDVFQP EDSASSVSGG
360 370 380 390 400
LFSILKKFEI PASNMVAVYI NDHELTSESV VSQIRELNPQ VIDLGGLYSI
410 420 430 440 450
PDTACSAGLQ THSVQVEELI ANIYRHFSTG STSNDNLKML FAGIDGLKVH
460 470 480 490 500
SNPLSNSEEF CVLVKRIHEM WSDLVSYFSS CDENNDNVKQ ICSQLENPKI
510 520 530 540 550
RLTLMFLDQA LGPLRAFGQH LQQSKSSVRA DLVEILREAS GLLRSYASSF
560 570 580 590 600
LRPQAVIRYL KEQDPAILDN EAFCLPAAEL SLGGVLEDFI SAREKELADF
610 620 630 640 650
LSTFYNECLA IYKTLTTSIA ASLPLSDSVL RAISQLLSPA GRLKVTGKNI
660 670 680 690 700
VDLAVRFGFC SKPEDSAKLN DEFLEYQLAE EENLSSTHSI ERYWCTVLKT
710 720 730 740 750
FPPTSVFKRL VLCLLVLPSP SLDATKIFAQ AIENGDADQL DDSSSESDTD
760 770 780 790 800
MTKELDSNDD NSLDNSELQI SPIKNGIMKK SRRSTSEVNL KNDGAKNDGT
810 820 830 840 850
LTSNTLKEVK NDLSNSTPSP RRGKRDQAYN DGKGFAVGEL VWGKVKDFSL
860 870 880 890 900
WPGLVVPWKG RIVPVSMRRV EWFGDGMFSE IHTDGLLPFG AFSKNFCSKS
910 920 930 940 950
YEGLPTYKNA IYQILELAAE RSGKLFPPSE KKGEEVKAMM DWAFGGFQPM
960 970 980 990 1000
GADGFLPSAD SSASNKTESD SSVSDYQPPA KRKYVFKNRP STQECNRDQM
1010 1020 1030 1040 1050
VQEVTSKGRK IEDFCLSCGS SNTETFHPLF KGSLCIKCKE NFTETLYRYD
1060 1070 1080 1090 1100
DDGYQSYCTV CCAGLEVILC GNASCCRCFC KDCLNVLVGP GTFDKLKEVD
1110 1120 1130 1140 1150
PWSCYVCLPS KCYGVLKLRT DWSVRVQEFF ANNSAFEFEP HRVYPSIPAH
1160 1170 1180 1190 1200
KRRPIRVLSL FDGIATGYLV LKDLGFKLER YIASEICEDS IAVGMVKHEG
1210 1220 1230 1240 1250
KIEYVKDVRT ITRKHLAEWG PFDLLIGGSP CNDLSMVNPA RKGLFEGTGR
1260 1270 1280 1290 1300
LFFEYYRMLT MMRPKEDDDR PFFWLFENVV AMSAHDKADI CRFLECNPVM
1310 1320 1330 1340 1350
IDAVKVSPAH RARYFWGNLP GMNRPVATSL TDNVDLQDCL ESGRTAMFSK
1360 1370 1380 1390 1400
VRTITTKSNS IKQGKTGPLP VTMNGKEDYL WCTEMEKIFG FPKHYTDVNN
1410 1420 1430
MGRGQRQKVL GRSWSVPVIR HLFAPLKDYF ACE
Length:1,433
Mass (Da):161,490
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E6483082FFCBF15
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB196918 mRNA Translation: BAD95481.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196918 mRNA Translation: BAD95481.1

3D structure databases

SMRiQ588C3
ModBaseiSearch...

Protein family/group databases

REBASEi11770, M.DreLDnmt7P

Organism-specific databases

ZFINiZDB-GENE-050314-4, dnmt3ba

Phylogenomic databases

OMAiTPYCVYV

Family and domain databases

CDDicd11728, ADDz_Dnmt3b, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR025766, ADD
IPR018117, C5_DNA_meth_AS
IPR001525, C5_MeTfrase
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR040552, DNMT3_ADD
IPR030488, DNMT3B_ADD
IPR000313, PWWP_dom
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF17980, ADD_DNMT3, 1 hit
PF00307, CH, 1 hit
PF00145, DNA_methylase, 1 hit
PF00855, PWWP, 1 hit
SMARTiView protein in SMART
SM00293, PWWP, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51533, ADD, 1 hit
PS00094, C5_MTASE_1, 1 hit
PS50021, CH, 1 hit
PS50812, PWWP, 1 hit
PS51679, SAM_MT_C5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ588C3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q588C3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 2, 2021
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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