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Entry version 120 (29 Sep 2021)
Sequence version 2 (04 Dec 2007)
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Protein

Putative ATP-dependent RNA helicase TDRD12

Gene

TDRD12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi460 – 467ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processDifferentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q587J7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase TDRD12 (EC:3.6.4.13)
Alternative name(s):
ES cell-associated transcript 8 protein
Tudor domain-containing protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD12
Synonyms:ECAT8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25044, TDRD12

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q587J7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000173809

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
91646

Open Targets

More...
OpenTargetsi
ENSG00000173809

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405542

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q587J7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TDRD12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416281

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119681 – 1177Putative ATP-dependent RNA helicase TDRD12Add BLAST1177

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q587J7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q587J7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q587J7

PeptideAtlas

More...
PeptideAtlasi
Q587J7

PRoteomics IDEntifications database

More...
PRIDEi
Q587J7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62600 [Q587J7-1]
62601 [Q587J7-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q587J7

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q587J7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q587J7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173809, Expressed in female gonad and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q587J7, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000173809, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a mRNP complex containing PIWIL2, TDRD1 and piRNAs.

Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124857, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q587J7, 2 interactors

Molecular INTeraction database

More...
MINTi
Q587J7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000390621

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q587J7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q587J7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 118Tudor 1Add BLAST63
Domaini447 – 635Helicase ATP-bindingAdd BLAST189
Domaini900 – 999Tudor 2Add BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1098 – 1177DisorderedSequence analysisAdd BLAST80

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi574 – 577DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1102 – 1124Polar residuesSequence analysisAdd BLAST23

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0331, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00420000029847

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008124_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q587J7

Database of Orthologous Groups

More...
OrthoDBi
231240at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q587J7

TreeFam database of animal gene trees

More...
TreeFami
TF332354

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04508, TUDOR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 2 hits
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR027417, P-loop_NTPase
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF00567, TUDOR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q587J7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQLLVLKIE DPGCFWVIIK GCSPFLDHDV DYQKLNSAMN DFYNSTCQDI
60 70 80 90 100
EIKPLTLEEG QVCVVYCEEL KCWCRAIVKS ITSSADQYLA ECFLVDFAKN
110 120 130 140 150
IPVKSKNIRV VVESFMQLPY RAKKFSLYCT KPVTLHIDFC RDSTDIVPAK
160 170 180 190 200
KWDNAAIQYF QNLLKATTQV EARLCAVEED TFEVYLYVTI KDEKVCVNDD
210 220 230 240 250
LVAKNYACYM SPTKNKNLDY LEKPRLNIKS APSFNKLNPA LTLWPMFLQG
260 270 280 290 300
KDVQGMEDSH GVNFPAQSLQ HTWCKGIVGD LRPTATAQDK AVKCNMDSLR
310 320 330 340 350
DSPKDKSEKK HHCISLKDTN KRVESSVYWP AKRGITIYAD PDVPEASALS
360 370 380 390 400
QKSNEKPLRL TEKKEYDEKN SCVKLLQFLN PDPLRADGIS DLQQLQKLKG
410 420 430 440 450
LQPPVVVLRN KIKPCLTIDS SPLSADLKKA LQRNKFPGPS HTESYSWPPI
460 470 480 490 500
ARGCDVVVIS HCESNPLLYL LPVLTVLQTG ACYKSLPSRN GPLAVIVCPG
510 520 530 540 550
WKKAQFIFEL LGEYSMSSRP LHPVLLTIGL HKEEAKNTKL PRGCDVIVTT
560 570 580 590 600
PYSLLRLLAC QSLLFLRLCH LILDEVEVLF LEANEQMFAI LDNFKKNIEV
610 620 630 640 650
EERESAPHQI VAVGVHWNKH IEHLIKEFMN DPYIVITAME EAALYGNVQQ
660 670 680 690 700
VVHLCLECEK TSSLLQALDF IPSQAQKTLI FTCSVAETEI VCKVVESSSI
710 720 730 740 750
FCLKMHKEMI FNLQNVLEQW KKKLSSGSQI ILALTDDCVP LLAITDATCV
760 770 780 790 800
IHFSFPASPK VFGGRLYCMS DHFHAEQGSP AEQGDKKAKS VLLLTEKDAS
810 820 830 840 850
HAVGVLRYLE RADAKVPAEL YEFTAGVLEA KEDKKAGRPL CPYLKAFGFC
860 870 880 890 900
KDKRICPDRH RINPETDLPR KLSSQALPSF GYIKIIPFYI LNATNYFGRI
910 920 930 940 950
VDKHMDLYAT LNAEMNEYFK DSNKTTVEKV EKFGLYGLAE KTLFHRVQVL
960 970 980 990 1000
EVNQKEDAWA LDDILVEFID EGRTGLVTRD QLLHLPEHFH TLPPQAVEFI
1010 1020 1030 1040 1050
VCRVKPADNE IEWNPKVTRY IHHKIVGKLH DAKVILALGN TVWIDPMVHI
1060 1070 1080 1090 1100
TNLSSLKTSV IDYNVRAEIL SMGMGIDNPE HIEQLKKLRE DAKIPACEES
1110 1120 1130 1140 1150
LSQTPPRVTG TSPAQDQDHP SEEQGGQGTP PAEDAACLQS PQPEDTGAEG
1160 1170
GAESKTSSEN QKPGGYLVFK RWLSSNR
Length:1,177
Mass (Da):132,578
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35C6C813A228132F
GO
Isoform 2 (identifier: Q587J7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     395-395: L → T
     396-1177: Missing.

Show »
Length:395
Mass (Da):45,033
Checksum:i7D93CB85DE5065E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y872A0A2R8Y872_HUMAN
Putative ATP-dependent RNA helicase...
TDRD12
1,335Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU57A0A1B0GU57_HUMAN
Putative ATP-dependent RNA helicase...
TDRD12
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRK2A0A1W2PRK2_HUMAN
Putative ATP-dependent RNA helicase...
TDRD12
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU70H3BU70_HUMAN
Putative ATP-dependent RNA helicase...
TDRD12
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD95490 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8K → Q in BAD95490 (PubMed:12787504).Curated1
Sequence conflicti107N → S in BAD95490 (PubMed:12787504).Curated1
Sequence conflicti413K → E in BC049000 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029675395L → T in isoform 2. 1 Publication1
Alternative sequenceiVSP_029676396 – 1177Missing in isoform 2. 1 PublicationAdd BLAST782

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008736 Genomic DNA No translation available.
AC008805 Genomic DNA No translation available.
BC049000 mRNA No translation available.
AB211063 mRNA Translation: BAD95490.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46038.1 [Q587J7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001104292.1, NM_001110822.1 [Q587J7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000421545; ENSP00000390621; ENSG00000173809 [Q587J7-2]
ENST00000444215; ENSP00000416248; ENSG00000173809 [Q587J7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
91646

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91646

UCSC genome browser

More...
UCSCi
uc002ntq.3, human [Q587J7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008736 Genomic DNA No translation available.
AC008805 Genomic DNA No translation available.
BC049000 mRNA No translation available.
AB211063 mRNA Translation: BAD95490.1 Different initiation.
CCDSiCCDS46038.1 [Q587J7-2]
RefSeqiNP_001104292.1, NM_001110822.1 [Q587J7-2]

3D structure databases

SMRiQ587J7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124857, 1 interactor
IntActiQ587J7, 2 interactors
MINTiQ587J7
STRINGi9606.ENSP00000390621

PTM databases

CarbonylDBiQ587J7
iPTMnetiQ587J7
PhosphoSitePlusiQ587J7

Genetic variation databases

BioMutaiTDRD12
DMDMi162416281

Proteomic databases

EPDiQ587J7
MassIVEiQ587J7
PaxDbiQ587J7
PeptideAtlasiQ587J7
PRIDEiQ587J7
ProteomicsDBi62600 [Q587J7-1]
62601 [Q587J7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
47944, 46 antibodies

The DNASU plasmid repository

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DNASUi
91646

Genome annotation databases

EnsembliENST00000421545; ENSP00000390621; ENSG00000173809 [Q587J7-2]
ENST00000444215; ENSP00000416248; ENSG00000173809 [Q587J7-1]
GeneIDi91646
KEGGihsa:91646
UCSCiuc002ntq.3, human [Q587J7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91646
DisGeNETi91646

GeneCards: human genes, protein and diseases

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GeneCardsi
TDRD12
HGNCiHGNC:25044, TDRD12
HPAiENSG00000173809, Tissue enriched (testis)
neXtProtiNX_Q587J7
OpenTargetsiENSG00000173809
PharmGKBiPA162405542
VEuPathDBiHostDB:ENSG00000173809

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0331, Eukaryota
GeneTreeiENSGT00420000029847
HOGENOMiCLU_008124_0_0_1
InParanoidiQ587J7
OrthoDBi231240at2759
PhylomeDBiQ587J7
TreeFamiTF332354

Enzyme and pathway databases

PathwayCommonsiQ587J7
ReactomeiR-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
91646, 6 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TDRD12, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91646
PharosiQ587J7, Tdark

Protein Ontology

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PROi
PR:Q587J7
RNActiQ587J7, protein

Gene expression databases

BgeeiENSG00000173809, Expressed in female gonad and 118 other tissues
ExpressionAtlasiQ587J7, baseline and differential

Family and domain databases

CDDicd04508, TUDOR, 1 hit
Gene3Di2.40.50.90, 2 hits
3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR027417, P-loop_NTPase
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00567, TUDOR, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDR12_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q587J7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 29, 2021
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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