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UniProtKB - Q587I9 (SFT2C_HUMAN)

Entry version 105 (10 Feb 2021)
Sequence version 1 (10 May 2005)
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Protein

Vesicle transport protein SFT2C

Gene

SFT2D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q587I9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicle transport protein SFT2C
Alternative name(s):
SFT2 domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFT2D3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28767, SFT2D3

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q587I9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173349.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 82CytoplasmicSequence analysisAdd BLAST82
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei83 – 103Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini104 – 107LumenalSequence analysis4
Transmembranei108 – 128Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini129 – 142CytoplasmicSequence analysisAdd BLAST14
Transmembranei143 – 163Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini164 – 166LumenalSequence analysis3
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini188 – 215CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84826

Open Targets

More...OpenTargetsi		ENSG00000173349

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670929

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q587I9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SFT2D3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74721667

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002386131 – 215Vesicle transport protein SFT2CAdd BLAST215

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q587I9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q587I9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q587I9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q587I9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q587I9

PeptideAtlas

More...PeptideAtlasi		Q587I9

PRoteomics IDEntifications database

More...PRIDEi		Q587I9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62599

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q587I9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q587I9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q587I9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173349, Expressed in nasal cavity epithelium and 150 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q587I9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173349, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124284, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q587I9, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000310803

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q587I9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q587I9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SFT2 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QV5D, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018525

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_099529_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q587I9

Identification of Orthologs from Complete Genome Data

More...OMAi		GFSWPWS

Database of Orthologous Groups

More...OrthoDBi		1371944at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q587I9

TreeFam database of animal gene trees

More...TreeFami		TF313609

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007305, Vesicle_transpt_Got1/SFT2
IPR011691, Vesicle_transpt_SFT2

The PANTHER Classification System

More...PANTHERi		PTHR23137, PTHR23137, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04178, Got1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q587I9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADLHRQLQE YLAQGKAGGP AAAEPLLAAE KAEEPGDRPA EEWLGRAGLR 
        60         70         80         90        100
WTWARSPAES AAAGLTCLPS VTRGQRLAAG GGCLLLAALC FGLAALYAPV 
       110        120        130        140        150
LLLRARKFAL LWSLGSALAL AGSALLRGGA ACGRLLRCEE APSRPALLYM 
       160        170        180        190        200
AALGATLFAA LGLRSTLLTV LGAGAQVAAL LAALVGLLPW GGGTALRLAL 
       210 
GRLGRGAGLA KVLPV
Length:215
Mass (Da):21,790
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8E02002ACA8650C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02655838R → G. Corresponds to variant dbSNP:rs10206957Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK074549 mRNA Translation: BAC11053.1
AC006011 Genomic DNA Translation: AAX82032.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2149.1

NCBI Reference Sequences

More...RefSeqi		NP_116129.3, NM_032740.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310981; ENSP00000310803; ENSG00000173349

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84826

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84826

UCSC genome browser

More...UCSCi		uc002tpf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074549 mRNA Translation: BAC11053.1
AC006011 Genomic DNA Translation: AAX82032.1
CCDSiCCDS2149.1
RefSeqiNP_116129.3, NM_032740.3

3D structure databases

SMRiQ587I9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124284, 6 interactors
IntActiQ587I9, 1 interactor
STRINGi9606.ENSP00000310803

PTM databases

iPTMnetiQ587I9
PhosphoSitePlusiQ587I9
SwissPalmiQ587I9

Genetic variation databases

BioMutaiSFT2D3
DMDMi74721667

Proteomic databases

EPDiQ587I9
jPOSTiQ587I9
MassIVEiQ587I9
MaxQBiQ587I9
PaxDbiQ587I9
PeptideAtlasiQ587I9
PRIDEiQ587I9
ProteomicsDBi62599

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		47566, 101 antibodies

Genome annotation databases

EnsembliENST00000310981; ENSP00000310803; ENSG00000173349
GeneIDi84826
KEGGihsa:84826
UCSCiuc002tpf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84826
DisGeNETi84826

GeneCards: human genes, protein and diseases

More...GeneCardsi		SFT2D3
HGNCiHGNC:28767, SFT2D3
HPAiENSG00000173349, Low tissue specificity
neXtProtiNX_Q587I9
OpenTargetsiENSG00000173349
PharmGKBiPA142670929
VEuPathDBiHostDB:ENSG00000173349.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QV5D, Eukaryota
GeneTreeiENSGT00390000018525
HOGENOMiCLU_099529_3_1_1
InParanoidiQ587I9
OMAiGFSWPWS
OrthoDBi1371944at2759
PhylomeDBiQ587I9
TreeFamiTF313609

Enzyme and pathway databases

PathwayCommonsiQ587I9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84826, 6 hits in 854 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SFT2D3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84826
PharosiQ587I9, Tdark

Protein Ontology

More...PROi		PR:Q587I9
RNActiQ587I9, protein

Gene expression databases

BgeeiENSG00000173349, Expressed in nasal cavity epithelium and 150 other tissues
GenevisibleiQ587I9, HS

Family and domain databases

InterProiView protein in InterPro
IPR007305, Vesicle_transpt_Got1/SFT2
IPR011691, Vesicle_transpt_SFT2
PANTHERiPTHR23137, PTHR23137, 1 hit
PfamiView protein in Pfam
PF04178, Got1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFT2C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q587I9
Secondary accession number(s): Q8N2P9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 10, 2005
Last modified: February 10, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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