UniProtKB - Q587I9 (SFT2C_HUMAN)
Protein
Vesicle transport protein SFT2C
Gene
SFT2D3
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.By similarity
GO - Biological processi
- protein transport Source: UniProtKB-KW
- vesicle-mediated transport Source: InterPro
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q587I9 |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle transport protein SFT2CAlternative name(s): SFT2 domain-containing protein 3 |
Gene namesi | Name:SFT2D3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28767, SFT2D3 |
neXtProti | NX_Q587I9 |
VEuPathDBi | HostDB:ENSG00000173349.5 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 82 | CytoplasmicSequence analysisAdd BLAST | 82 | |
Transmembranei | 83 – 103 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 104 – 107 | LumenalSequence analysis | 4 | |
Transmembranei | 108 – 128 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 129 – 142 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 143 – 163 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 164 – 166 | LumenalSequence analysis | 3 | |
Transmembranei | 167 – 187 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 215 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84826 |
OpenTargetsi | ENSG00000173349 |
PharmGKBi | PA142670929 |
Miscellaneous databases
Pharosi | Q587I9, Tdark |
Genetic variation databases
BioMutai | SFT2D3 |
DMDMi | 74721667 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000238613 | 1 – 215 | Vesicle transport protein SFT2CAdd BLAST | 215 |
Proteomic databases
EPDi | Q587I9 |
jPOSTi | Q587I9 |
MassIVEi | Q587I9 |
MaxQBi | Q587I9 |
PaxDbi | Q587I9 |
PeptideAtlasi | Q587I9 |
PRIDEi | Q587I9 |
ProteomicsDBi | 62599 |
PTM databases
iPTMneti | Q587I9 |
PhosphoSitePlusi | Q587I9 |
SwissPalmi | Q587I9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173349, Expressed in nasal cavity epithelium and 150 other tissues |
Genevisiblei | Q587I9, HS |
Organism-specific databases
HPAi | ENSG00000173349, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124284, 6 interactors |
IntActi | Q587I9, 1 interactor |
STRINGi | 9606.ENSP00000310803 |
Miscellaneous databases
RNActi | Q587I9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SFT2 family.Sequence analysis
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QV5D, Eukaryota |
GeneTreei | ENSGT00390000018525 |
HOGENOMi | CLU_099529_3_1_1 |
InParanoidi | Q587I9 |
OMAi | GFSWPWS |
OrthoDBi | 1371944at2759 |
PhylomeDBi | Q587I9 |
TreeFami | TF313609 |
Family and domain databases
InterProi | View protein in InterPro IPR007305, Vesicle_transpt_Got1/SFT2 IPR011691, Vesicle_transpt_SFT2 |
PANTHERi | PTHR23137, PTHR23137, 1 hit |
Pfami | View protein in Pfam PF04178, Got1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q587I9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADLHRQLQE YLAQGKAGGP AAAEPLLAAE KAEEPGDRPA EEWLGRAGLR
60 70 80 90 100
WTWARSPAES AAAGLTCLPS VTRGQRLAAG GGCLLLAALC FGLAALYAPV
110 120 130 140 150
LLLRARKFAL LWSLGSALAL AGSALLRGGA ACGRLLRCEE APSRPALLYM
160 170 180 190 200
AALGATLFAA LGLRSTLLTV LGAGAQVAAL LAALVGLLPW GGGTALRLAL
210
GRLGRGAGLA KVLPV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026558 | 38 | R → G. Corresponds to variant dbSNP:rs10206957Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074549 mRNA Translation: BAC11053.1 AC006011 Genomic DNA Translation: AAX82032.1 |
CCDSi | CCDS2149.1 |
RefSeqi | NP_116129.3, NM_032740.3 |
Genome annotation databases
Ensembli | ENST00000310981; ENSP00000310803; ENSG00000173349 |
GeneIDi | 84826 |
KEGGi | hsa:84826 |
UCSCi | uc002tpf.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074549 mRNA Translation: BAC11053.1 AC006011 Genomic DNA Translation: AAX82032.1 |
CCDSi | CCDS2149.1 |
RefSeqi | NP_116129.3, NM_032740.3 |
3D structure databases
SMRi | Q587I9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124284, 6 interactors |
IntActi | Q587I9, 1 interactor |
STRINGi | 9606.ENSP00000310803 |
PTM databases
iPTMneti | Q587I9 |
PhosphoSitePlusi | Q587I9 |
SwissPalmi | Q587I9 |
Genetic variation databases
BioMutai | SFT2D3 |
DMDMi | 74721667 |
Proteomic databases
EPDi | Q587I9 |
jPOSTi | Q587I9 |
MassIVEi | Q587I9 |
MaxQBi | Q587I9 |
PaxDbi | Q587I9 |
PeptideAtlasi | Q587I9 |
PRIDEi | Q587I9 |
ProteomicsDBi | 62599 |
Protocols and materials databases
Antibodypediai | 47566, 101 antibodies |
Genome annotation databases
Ensembli | ENST00000310981; ENSP00000310803; ENSG00000173349 |
GeneIDi | 84826 |
KEGGi | hsa:84826 |
UCSCi | uc002tpf.4, human |
Organism-specific databases
CTDi | 84826 |
DisGeNETi | 84826 |
GeneCardsi | SFT2D3 |
HGNCi | HGNC:28767, SFT2D3 |
HPAi | ENSG00000173349, Low tissue specificity |
neXtProti | NX_Q587I9 |
OpenTargetsi | ENSG00000173349 |
PharmGKBi | PA142670929 |
VEuPathDBi | HostDB:ENSG00000173349.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QV5D, Eukaryota |
GeneTreei | ENSGT00390000018525 |
HOGENOMi | CLU_099529_3_1_1 |
InParanoidi | Q587I9 |
OMAi | GFSWPWS |
OrthoDBi | 1371944at2759 |
PhylomeDBi | Q587I9 |
TreeFami | TF313609 |
Enzyme and pathway databases
PathwayCommonsi | Q587I9 |
Miscellaneous databases
BioGRID-ORCSi | 84826, 6 hits in 854 CRISPR screens |
ChiTaRSi | SFT2D3, human |
GenomeRNAii | 84826 |
Pharosi | Q587I9, Tdark |
PROi | PR:Q587I9 |
RNActi | Q587I9, protein |
Gene expression databases
Bgeei | ENSG00000173349, Expressed in nasal cavity epithelium and 150 other tissues |
Genevisiblei | Q587I9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007305, Vesicle_transpt_Got1/SFT2 IPR011691, Vesicle_transpt_SFT2 |
PANTHERi | PTHR23137, PTHR23137, 1 hit |
Pfami | View protein in Pfam PF04178, Got1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SFT2C_HUMAN | |
Accessioni | Q587I9Primary (citable) accession number: Q587I9 Secondary accession number(s): Q8N2P9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM