MJ1226

Functionⁱ

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	311	4-aspartylphosphate intermediateBy similarity		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
proton-exporting ATPase activity, phosphorylative mechanism
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

proton export across plasma membrane Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBⁱ	3.A.3.3.4 the p-type atpase (p-atpase) superfamily

TCDBⁱ

3.A.3.3.4 the p-type atpase (p-atpase) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative cation-transporting ATPase MJ1226 (EC:3.6.3.-)
Gene namesⁱ	Ordered Locus Names:MJ1226
Organismⁱ	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifierⁱ	243232 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus jannaschii
Proteomesⁱ	UP000000805 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell membrane Curated; Multi-pass membrane protein Curated

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	53 – 73	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	75 – 95	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	226 – 246	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	258 – 278	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	615 – 637	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	641 – 663	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	680 – 700	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	712 – 734	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	747 – 769	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	773 – 790	HelicalSequence analysisAdd BLAST	18

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046427	1 – 805	Putative cation-transporting ATPase MJ1226Add BLAST		805

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PRIDEⁱ	Q58623

PRIDEⁱ

Q58623

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	243232.MJ_1226

STRINGⁱ

243232.MJ_1226

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q58623
SMRⁱ	Q58623
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	arCOG01578 Archaea COG0474 LUCA
InParanoidⁱ	Q58623
KEGG Orthology (KO) More...KOⁱ	K01535
OMAⁱ	KIWIISV
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z00KF
PhylomeDBⁱ	Q58623

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02076 P-type_ATPase_H, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006534 P-type_ATPase_IIIA IPR001757 P_typ_ATPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00690 Cation_ATPase_N, 1 hit
PRINTSⁱ	PR00120 HATPASE
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01647 ATPase-IIIA_H, 1 hit TIGR01494 ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q58623-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWGVVMNVEE IEEEYKTSIK TGLSTEEAKK RLKIYGYNEI PEKKVHPIIK 
        60         70         80         90        100
FLSYFWNPIA WMIEIAAILS AIIKHWVDFV IILILLLVNG VVGFWEEYKA 
       110        120        130        140        150
ENVIEFLKQK MALNARVLRD GKWQIIPAKE LVPGDVVRIR IGDIVPADII 
       160        170        180        190        200
LVDGDYLVVD ESALTGESLP VEKKIGDIAY SGSIVKKGEM TGIVKATGLN 
       210        220        230        240        250
TYFGKTVKLV EKAEKVSSYQ KMIIKIGDYL IVLAVILIAI MVAVELFRGK 
       260        270        280        290        300
SLIETAQFAL VLAVSAIPAA MPAVLSITMA IGALNLAKKD AIVKKLVAIE 
       310        320        330        340        350
ELAGVDILCS DKTGTLTKNQ LVCGEIIALN GFSKEDVVLF AALASREEDA 
       360        370        380        390        400
DAIDMAILNE AKKLGLMEKI KNYKIKKFIP FDPVIKRTEA EVTNDEEFKV 
       410        420        430        440        450
SKGAPQVILD LCNADEELRR KVEEIVDKLA ENGYRALGVA VYKNGRWHFA 
       460        470        480        490        500
GIIPLYDPPR EDAPLAVKKI KELGVIIKMV TGDHVAIAKN IARMLGIGDK 
       510        520        530        540        550
IISISELLKK LKRGEIKEEK FDEIVEEADG FAEVFPEHKY KIVDSLQKRG 
       560        570        580        590        600
HLVAMTGDGV NDAPALKKAD CGIAVSNATD AARAAADIVL LSPGISVIVD 
       610        620        630        640        650
AIQEARRIFQ RMESYVIYRI TETIRILFFV ELCILILGIY PITALMIVLL 
       660        670        680        690        700
AILNDIPILA IAYDNVVEPK SPVRWRMREI LMLSTALGLS GVVSSFLIFY 
       710        720        730        740        750
ISDVFLHLTI AELQSFVFLK LILAGHATIF VTRIRDRLWK KPYPSKLLFW 
       760        770        780        790        800
GVMGTNIIGT IVAAEGIFMA PIGWDLALFM WLYAHVWMLI NDEIKMILLK 

RLKID

Length:805

Mass (Da):89,618

Last modified:November 1, 1996 - v1

Checksum:ⁱ8E63D3F7E47668CD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L77117 Genomic DNA Translation: AAB99229.1
PIRⁱ	A64453

Genome annotation databases

EnsemblBacteriaⁱ	AAB99229; AAB99229; MJ_1226
KEGGⁱ	mja:MJ_1226

Protein	Similar proteins		Species	Score	Length	Source
Q58623	Plasma-membrane proton-efflux P-type ATPase		METSF		800	UniRef90_Q58623
Plasma-membrane proton-efflux P-type ATPase		Methanocaldococcus bathoardescens		800
UPI0007DBFD6D		Methanocaldococcus jannaschii		800

Protein	Similar proteins		Species	Score	Length	Source
Q58623	Plasma-membrane proton-efflux P-type ATPase		Methanocaldococcus bathoardescens		800	UniRef50_Q58623
Plasma-membrane proton-efflux P-type ATPase		METSF		800
Plasma-membrane proton-efflux P-type ATPase		Mycobacterium paraseoulense		806
Copper-exporting P-type ATPase B		Methanoregula sp. PtaU1.Bin006		807
Plasma-membrane proton-efflux P-type ATPase		Methanolobus tindarius DSM 2278		815
+218

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L77117 Genomic DNA Translation: AAB99229.1
PIRⁱ	A64453

3D structure databases

ProteinModelPortalⁱ	Q58623
SMRⁱ	Q58623
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	243232.MJ_1226

STRINGⁱ

243232.MJ_1226

Protein family/group databases

TCDBⁱ	3.A.3.3.4 the p-type atpase (p-atpase) superfamily

TCDBⁱ

3.A.3.3.4 the p-type atpase (p-atpase) superfamily

Proteomic databases

PRIDEⁱ	Q58623

PRIDEⁱ

Q58623

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAB99229; AAB99229; MJ_1226
KEGGⁱ	mja:MJ_1226

Phylogenomic databases

eggNOGⁱ	arCOG01578 Archaea COG0474 LUCA
InParanoidⁱ	Q58623
KOⁱ	K01535
OMAⁱ	KIWIISV
OrthoDBⁱ	POG093Z00KF
PhylomeDBⁱ	Q58623

Family and domain databases

CDDⁱ	cd02076 P-type_ATPase_H, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006534 P-type_ATPase_IIIA IPR001757 P_typ_ATPase
Pfamⁱ	View protein in Pfam PF00690 Cation_ATPase_N, 1 hit
PRINTSⁱ	PR00120 HATPASE
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01647 ATPase-IIIA_H, 1 hit TIGR01494 ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Y1226_METJA
Accessionⁱ	Q58623Primary (citable) accession number: Q58623
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniParc

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UniProtKB - Q58623 (Y1226_METJA)

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Putative cation-transporting ATPase MJ1226

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ