UniProtKB - Q58605 (METK_METJA)
Protein
S-adenosylmethionine synthase
Gene
mat
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Functioni
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.1 Publication
Catalytic activityi
- EC:2.5.1.61 Publication
Cofactori
Mg2+1 Publication
: S-adenosyl-L-methionine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.1 PublicationProteins known to be involved in this subpathway in this organism are:
- S-adenosylmethionine synthase (mat)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 141 – 146 | ATPSequence analysis | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
- methionine adenosyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- one-carbon metabolic process Source: UniProtKB-UniRule
- S-adenosylmethionine biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Biological process | One-carbon metabolism |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MJAN243232:G1GKE-1311-MONOMER |
BRENDAi | 2.5.1.6, 3260 |
UniPathwayi | UPA00315;UER00080 |
Names & Taxonomyi
Protein namesi | Recommended name: S-adenosylmethionine synthase (EC:2.5.1.6)Short name: AdoMet synthase Alternative name(s): Methionine adenosyltransferase |
Gene namesi | Name:mat Ordered Locus Names:MJ1208 |
Organismi | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) |
Taxonomic identifieri | 243232 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150028 | 1 – 406 | S-adenosylmethionine synthaseAdd BLAST | 406 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 243232.MJ_1208 |
Family & Domainsi
Sequence similaritiesi
Belongs to the AdoMet synthase 2 family.Curated
Phylogenomic databases
eggNOGi | arCOG01678, Archaea |
HOGENOMi | CLU_057642_0_0_2 |
InParanoidi | Q58605 |
OMAi | IGHPDSI |
OrthoDBi | 21658at2157 |
PhylomeDBi | Q58605 |
Family and domain databases
Gene3Di | 3.30.300.280, 1 hit 3.30.300.340, 1 hit |
HAMAPi | MF_00136, S_AdoMet_synth2, 1 hit |
InterProi | View protein in InterPro IPR042543, AdoMet_synthase_2 IPR027790, AdoMet_synthase_2_family IPR042544, AdoMet_synthase_3 IPR002795, S-AdoMet_synthetase_arc |
PANTHERi | PTHR36697, PTHR36697, 1 hit |
Pfami | View protein in Pfam PF01941, AdoMet_Synthase, 1 hit |
i Sequence
Sequence statusi: Complete.
Q58605-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRNIIVKKLD VEPIEERPTE IVERKGLGHP DSICDGIAES VSRALCKMYM
60 70 80 90 100
EKFGTILHHN TDQVELVGGH AYPKFGGGVM VSPIYILLSG RATMEILDKE
110 120 130 140 150
KNEVIKLPVG TTAVKAAKEY LKKVLRNVDV DKDVIIDCRI GQGSMDLVDV
160 170 180 190 200
FERQKNEVPL ANDTSFGVGY APLSTTERLV LETERFLNSD ELKNEIPAVG
210 220 230 240 250
EDIKVMGLRE GKKITLTIAM AVVDRYVKNI EEYKEVIEKV RKKVEDLAKK
260 270 280 290 300
IADGYEVEIH INTADDYERE SVYLTVTGTS AEMGDDGSVG RGNRVNGLIT
310 320 330 340 350
PFRPMSMEAA SGKNPVNHVG KIYNILANLI ANDIAKLEGV KECYVRILSQ
360 370 380 390 400
IGKPINEPKA LDIEIITEDS YDIKDIEPKA KEIANKWLDN IMEVQKMIVE
GKVTTF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L77117 Genomic DNA Translation: AAB99212.1 |
PIRi | G64450 |
RefSeqi | WP_010870720.1, NC_000909.1 |
Genome annotation databases
EnsemblBacteriai | AAB99212; AAB99212; MJ_1208 |
GeneIDi | 1452105 |
KEGGi | mja:MJ_1208 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L77117 Genomic DNA Translation: AAB99212.1 |
PIRi | G64450 |
RefSeqi | WP_010870720.1, NC_000909.1 |
3D structure databases
SMRi | Q58605 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 243232.MJ_1208 |
Genome annotation databases
EnsemblBacteriai | AAB99212; AAB99212; MJ_1208 |
GeneIDi | 1452105 |
KEGGi | mja:MJ_1208 |
Phylogenomic databases
eggNOGi | arCOG01678, Archaea |
HOGENOMi | CLU_057642_0_0_2 |
InParanoidi | Q58605 |
OMAi | IGHPDSI |
OrthoDBi | 21658at2157 |
PhylomeDBi | Q58605 |
Enzyme and pathway databases
UniPathwayi | UPA00315;UER00080 |
BioCyci | MJAN243232:G1GKE-1311-MONOMER |
BRENDAi | 2.5.1.6, 3260 |
Family and domain databases
Gene3Di | 3.30.300.280, 1 hit 3.30.300.340, 1 hit |
HAMAPi | MF_00136, S_AdoMet_synth2, 1 hit |
InterProi | View protein in InterPro IPR042543, AdoMet_synthase_2 IPR027790, AdoMet_synthase_2_family IPR042544, AdoMet_synthase_3 IPR002795, S-AdoMet_synthetase_arc |
PANTHERi | PTHR36697, PTHR36697, 1 hit |
Pfami | View protein in Pfam PF01941, AdoMet_Synthase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | METK_METJA | |
Accessioni | Q58605Primary (citable) accession number: Q58605 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families