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Protein

Flagellar attachment zone protein 1

Gene

FAZ1

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cilium assembly Source: GeneDB
  • mitotic cytokinesis Source: GeneDB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flagellar attachment zone protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAZ11 Publication
ORF Names:Tb927.4.3740
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri185431 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008524 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TriTrypDB:Tb927.4.3740

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

  • ciliary pocket Source: GeneDB
  • cilium Source: GeneDB
  • cytoskeleton Source: GeneDB
  • motile cilium Source: UniProtKB-SubCell
  • protein-containing complex Source: GeneDB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Assembly of a compromised FAZ and defects in flagellum attachment and cytokinesis in procyclic trypanosomes resulting in generation of 0N1K cells (zoids) and multinucleated cells, demonstrates the role of an attached flagellum in cellular morphogenesis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004146061 – 1692Flagellar attachment zone protein 1Add BLAST1692

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q585H6

PRoteomics IDEntifications database

More...
PRIDEi
Q585H6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5691.AAZ10965

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q585H6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q585H6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1012 – 10251Sequence analysisAdd BLAST14
Repeati1026 – 10392Sequence analysisAdd BLAST14
Repeati1040 – 10533Sequence analysisAdd BLAST14
Repeati1054 – 10674Sequence analysisAdd BLAST14
Repeati1068 – 10815Sequence analysisAdd BLAST14
Repeati1082 – 10956Sequence analysisAdd BLAST14
Repeati1096 – 11097Sequence analysisAdd BLAST14
Repeati1110 – 11238Sequence analysisAdd BLAST14
Repeati1124 – 11379Sequence analysisAdd BLAST14
Repeati1138 – 115110Sequence analysisAdd BLAST14
Repeati1152 – 116511Sequence analysisAdd BLAST14
Repeati1166 – 117912Sequence analysisAdd BLAST14
Repeati1180 – 119313Sequence analysisAdd BLAST14
Repeati1194 – 120714Sequence analysisAdd BLAST14
Repeati1208 – 122115Sequence analysisAdd BLAST14
Repeati1222 – 123516Sequence analysisAdd BLAST14
Repeati1236 – 124917Sequence analysisAdd BLAST14
Repeati1250 – 126318Sequence analysisAdd BLAST14
Repeati1264 – 127719Sequence analysisAdd BLAST14
Repeati1278 – 129120Sequence analysisAdd BLAST14
Repeati1292 – 130521Sequence analysisAdd BLAST14
Repeati1306 – 131922Sequence analysisAdd BLAST14
Repeati1320 – 133323Sequence analysisAdd BLAST14
Repeati1334 – 134724Sequence analysisAdd BLAST14
Repeati1348 – 136125Sequence analysisAdd BLAST14
Repeati1362 – 137526Sequence analysisAdd BLAST14
Repeati1376 – 138927Sequence analysisAdd BLAST14
Repeati1390 – 140328Sequence analysisAdd BLAST14
Repeati1404 – 141729Sequence analysisAdd BLAST14
Repeati1418 – 143130Sequence analysisAdd BLAST14
Repeati1432 – 144531Sequence analysisAdd BLAST14
Repeati1446 – 145932Sequence analysisAdd BLAST14
Repeati1460 – 147333Sequence analysisAdd BLAST14
Repeati1474 – 148734Sequence analysisAdd BLAST14
Repeati1488 – 150135Sequence analysisAdd BLAST14
Repeati1502 – 151536Sequence analysisAdd BLAST14
Repeati1516 – 152937Sequence analysisAdd BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1012 – 152937 X 14 AA tandem repeats of E-E-L-E-L-K-[VA]-A-E-N-E-K-L-ASequence analysisAdd BLAST518

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili613 – 657Sequence analysisAdd BLAST45
Coiled coili684 – 864Sequence analysisAdd BLAST181
Coiled coili903 – 1607Sequence analysisAdd BLAST705

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 48Poly-ValSequence analysis4
Compositional biasi688 – 1544Glu-richSequence analysisAdd BLAST857

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000136050

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q585H6

KEGG Orthology (KO)

More...
KOi
K20478

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDAIANC

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q585H6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLNVISEN PLTLQPGQVI AFDHLANGEH WQWALGTVVS SDKHVVVVEQ
60 70 80 90 100
WAVNEGSCET LKHNISSEIQ KEMKRMGVFQ EQLSSARDKL AAIRSENEDR
110 120 130 140 150
VSAARAVFED AKARVASVDE VHMREVTSQA CPSPVAVEVL KSVLALAQND
160 170 180 190 200
PTVTNCSTWD DIRMEYRRPN AIADFISADI TGKTYPNAEE ICSSLNEQRL
210 220 230 240 250
SSLAASRDSE AISSLHHWVL SALAYQEAYC RLTTDTRVQE QNDAIANCIA
260 270 280 290 300
GMKGCRLKVM KLKEELERGG TPTFGGQLTS FTKTSVQLKA PLSSVISIVG
310 320 330 340 350
VDPSAQDCVL TDDEVGLILD KAEQTRLQIN DHFSHLSNSY MEAMAELHCL
360 370 380 390 400
SMYTSELEER RLNLQERFVF SLFTNAGKTN APRRERIETD VGLRSVEAPR
410 420 430 440 450
GDSANNIKDL QEIIKELSSH DERWMYRNEP TVTTKHRKSY PGREWSKVVE
460 470 480 490 500
RKPEELLSTF RTEQAAACHV PEDAIRNIEF TATSEKLQVS FDVQHPVKQT
510 520 530 540 550
AAEINKRLQE FPSRGMDRML CDVDQPKKGL DRAIVEVCRA FDLREHAFRG
560 570 580 590 600
MTFDKFIEEV AMKGRVGDKD AYESEIGDLL MLLDKIHNEN RSLQYTLEKS
610 620 630 640 650
AEEFRRQTAS TMREQESLRQ RNGELHAEIG RLRDLVEKLR DLADNQASEL
660 670 680 690 700
ELLKLQKTQA NQIRAQRNLS TFRGDDTAEP VYCVTLDELR EQTEHCDQVE
710 720 730 740 750
RELERQREQC QNLLNAQDDL LAELSGVSEE KEKLEAECER LEAELRQMEE
760 770 780 790 800
KSRLSEQGLS EMTQRLEEKQ AEIEGLLENL EQLDEQLEAL RAAEKSAQAH
810 820 830 840 850
IEARDREISD LQQRLEGEID DHIKTTALLE ELRKHYNNLE ELFDKQEAEL
860 870 880 890 900
MAYREKRQNA HKVRSLEPTL RPIGTQTKPF QEMVSADEIS SEPLLSVTLD
910 920 930 940 950
EYNDHMHRSN QFQQENDLLR QQLQQANDER ENLHDRLEQL MAENQSLSEQ
960 970 980 990 1000
LHNMHEELER EERDRSGVTL QNERLAEEIQ RKTAENEQLV LENNKSRSDI
1010 1020 1030 1040 1050
RNLNVQVQRL MEELELKAAE NEKLAEELEL KAAENEKLAE ELELKVAENE
1060 1070 1080 1090 1100
KLAEELELKV AENEKLAEEL ELKAAENEKL AEELELKAAE NEKLAEELEL
1110 1120 1130 1140 1150
KAAENEKLAE ELELKAAENE KLAEELELKA AENEKLAEEL ELKAAENEKL
1160 1170 1180 1190 1200
AEELELKAAE NEKLAEELEL KVAENEKLAE ELELKAAENE KLAEELELKV
1210 1220 1230 1240 1250
AENEKLAEEL ELKAAENEKL AEELELKAAE NEKLAEELEL KAAENEKLAE
1260 1270 1280 1290 1300
ELELKAAENE KLAEELELKV AENEKLAEEL ELKAAENEKL AEELELKVAE
1310 1320 1330 1340 1350
NEKLAEELEL KAAENEKLAE ELELKVAENE KLAEELELKA AENEKLAEEL
1360 1370 1380 1390 1400
ELKVAENEKL AEELELKAAE NEKLAEELEL KAAENEKLAE ELELKAAENE
1410 1420 1430 1440 1450
KLAEELELKA AENEKLAEEL ELKAAENEKL AEELELKVAE NEKLAEELEL
1460 1470 1480 1490 1500
KAAENEKLAE ELELKVAENE KLAEELELKA AENEKLAEEL ELKAAENEKL
1510 1520 1530 1540 1550
AEELELKAAE NEKLAEELEL KVAENKRLAE EVTQRLSEKE LLAEDTSARL
1560 1570 1580 1590 1600
LEADSANSAL QCKVKHLEEK LTLLSSEKET ALATLEAEIV DLLTQLKGLN
1610 1620 1630 1640 1650
GTNSALESLC ASKEKELVFL REHCELWTDP TTKKEKVITR HVKVFDGNEW
1660 1670 1680 1690
MKLITDRPEA LMSAFVIDAG NACHVPGDQI HEVSFLNNKE KH
Length:1,692
Mass (Da):192,570
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8ABB32A892D144C0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC023489 Genomic DNA Translation: AAX79229.1
CP000067 Genomic DNA Translation: AAZ10965.1

NCBI Reference Sequences

More...
RefSeqi
XP_844524.1, XM_839431.1

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
Tb927.4.3740:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3656912

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tbr:Tb927.4.3740

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023489 Genomic DNA Translation: AAX79229.1
CP000067 Genomic DNA Translation: AAZ10965.1
RefSeqiXP_844524.1, XM_839431.1

3D structure databases

ProteinModelPortaliQ585H6
SMRiQ585H6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5691.AAZ10965

Proteomic databases

PaxDbiQ585H6
PRIDEiQ585H6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.4.3740:pep
GeneIDi3656912
KEGGitbr:Tb927.4.3740

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.4.3740

Phylogenomic databases

HOGENOMiHOG000136050
InParanoidiQ585H6
KOiK20478
OMAiNDAIANC

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAZ1_TRYB2
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q585H6
Secondary accession number(s): D6XFW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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