Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 94 (05 Dec 2018)
Sequence version 1 (10 May 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Receptor-type adenylate cyclase GRESAG 4, putative

Gene

Tb927.4.4460

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adenylate cyclase activity Source: GeneDB
  • ATP binding Source: GeneDB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseSAAS annotationImported, ReceptorImported
LigandNucleotide-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Receptor-type adenylate cyclase GRESAG 4, putativeImported (EC:4.6.1.1Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Tb927.4.4460Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri185431 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008524 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TriTrypDB:Tb927.4.4460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei834 – 856HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q583D1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5691.AAZ11036

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini878 – 1032Guanylate cyclaseInterPro annotationAdd BLAST155

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000063251

KEGG Orthology (KO)

More...
KOi
K01768

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211 Guanylate_cyc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044 CYCc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 2 hits
SSF55073 SSF55073, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q583D1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTFMRELYV RDGAVTYVVF SLLLQVLTAS SLANDKIQVK VYNMLYSNKI
60 70 80 90 100
SAKIYDPIIA GFNASITNGN PPSGANVEVV YVPPMDDSKY ADFLNNETSF
110 120 130 140 150
GENNKISIIL GPVGDQNTLG LLKYFKEKNV TSFSPFTGSS KVRSWNPNLY
160 170 180 190 200
FLTASPAAEM LALLRYAITQ LRLHRLGFMY LKDVSYGDDE YKLAVELTTR
210 220 230 240 250
MDRKLCGVFA LKSQIEKESD DSSFSAEWNK FANTRPQGVI VFGSPIPDTK
260 270 280 290 300
KFLIKSLEDE RTKGGYLLIP STLQYVIKNK WSEELGRDRF VPGKIIITGT
310 320 330 340 350
NPLAKDDGYD AIKRFRGELA NFLKVNGNNF SKDNWNVTLN ANENNFTEQD
360 370 380 390 400
TEGELMVSGW IAGEVLKQAL SCREWLTSRD AFITSLYNQR RYVIDDIVVG
410 420 430 440 450
DFGGECRGMA GERGASCLCN QGGNVVYMKK MEEDHRLYPM KEGVLALTSS
460 470 480 490 500
RCYRDLSQLY APLSGIMFKL TDDPKALRTA EAIYDGAFYV VGKGQLGHSD
510 520 530 540 550
RFFLHWLSSK SHDTSTALYD EVEKRVVTAV FGVVDDSLLS TKGMAFIDPI
560 570 580 590 600
TLTPQLSNPR RNVIHLSPTL EQQLFVIVEH IIQNGAGKMH AIVRSGDTKD
610 620 630 640 650
IGEMLNKTLD FFESSLSSFV ASGEGSTLRD KLPTAGEVLV AGLISDDIPI
660 670 680 690 700
ILSHLGKHHN VRIFVPFFDV ALLYDELVSA FRDKPFADRL LFATNLPHWG
710 720 730 740 750
DKNTESDLVR EFHRVVQNES KWKPLSLLGY VTARAMINVL QRMGHVTPED
760 770 780 790 800
LVDAIFSQSV ITVDDMRYGP FDDKCTNGAS FEEKHCAVNY GATHISVWSM
810 820 830 840 850
SRVLNPSVSP VVTHVTPLMM DGYAKWFRLK RGHIAAIAVS CVVVLALFVT
860 870 880 890 900
VLLLVIRSSR RNARDNNNAP KEPTDPVTLI FTDIESSTAQ WAAHPEQMPD
910 920 930 940 950
LVATHHRLIR SLITRYECYE VKTVGDSFMI ACKSPFAAAQ LACDLQRDFL
960 970 980 990 1000
NHDWKTTELD ESYREFERKR AEDDSDYTPP TASLDPEVYR QLWNGLRVRV
1010 1020 1030 1040 1050
GIHTGLCDIR HDEVTKGYDY YGRTSNMAAR TESVGNGGQV LMTRSTYLSL
1060 1070 1080 1090 1100
SGKEREQINV TPLGDVPLRG VPKPVEMYQL NAVPGRTFAA LRLDRDVEDE
1110 1120 1130 1140 1150
ENEESEGIFT DVSDICSSTH ELCGSSLHVA QSLETVLGTL PATQRQRMLT
1160 1170 1180 1190 1200
SICERWRVPP PKSVKNRWDK ATFRLAVHHI AVRAGPIMNV VIRNSTGTAL
1210 1220 1230 1240 1250
STERSSFALS HSICDVSQLG RQHPLPSVRF HTPMEVKEYL CMSPTDKFDF
1260 1270 1280
SIYSCSTIDI NMFNGTLEKF DSREPLFGTS LGDNGKNS
Length:1,288
Mass (Da):144,260
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA76C8434D1316831
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC087327 Genomic DNA Translation: AAX80524.1
CP000067 Genomic DNA Translation: AAZ11036.1

NCBI Reference Sequences

More...
RefSeqi
XP_844595.1, XM_839502.1

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
Tb927.4.4460:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3656981

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tbr:Tb927.4.4460

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087327 Genomic DNA Translation: AAX80524.1
CP000067 Genomic DNA Translation: AAZ11036.1
RefSeqiXP_844595.1, XM_839502.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi5691.AAZ11036

Proteomic databases

PaxDbiQ583D1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.4.4460:pep
GeneIDi3656981
KEGGitbr:Tb927.4.4460

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.4.4460

Phylogenomic databases

HOGENOMiHOG000063251
KOiK01768

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF53822 SSF53822, 2 hits
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ583D1_TRYB2
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q583D1
Secondary accession number(s): D6XEK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: December 5, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again