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Entry version 125 (18 Sep 2019)
Sequence version 1 (10 May 2005)
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Protein
Submitted name:

Multidrug resistance protein A

Gene

Tb927.8.2160

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi705 – 712ATPPROSITE-ProRule annotation8
Nucleotide bindingi1356 – 1363ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • response to drug Source: GeneDB
  • transmembrane transport Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Multidrug resistance protein AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:Tb927.8.2160Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri185431 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008524 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TriTrypDB:Tb927.8.2160

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Transmembranei373 – 391HelicalSequence analysisAdd BLAST19
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Transmembranei516 – 537HelicalSequence analysisAdd BLAST22
Transmembranei964 – 991HelicalSequence analysisAdd BLAST28
Transmembranei1011 – 1031HelicalSequence analysisAdd BLAST21
Transmembranei1082 – 1104HelicalSequence analysisAdd BLAST23
Transmembranei1110 – 1130HelicalSequence analysisAdd BLAST21
Transmembranei1200 – 1220HelicalSequence analysisAdd BLAST21
Transmembranei1226 – 1247HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q581W6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5691.AAZ12983

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini264 – 539ABC transmembrane type-1InterPro annotationAdd BLAST276
Domaini673 – 893ABC transporterInterPro annotationAdd BLAST221
Domaini975 – 1255ABC transmembrane type-1InterPro annotationAdd BLAST281
Domaini1324 – 1557ABC transporterInterPro annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni636 – 676DisorderedSequence analysisAdd BLAST41
Regioni897 – 937DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 32PolarSequence analysisAdd BLAST16
Compositional biasi897 – 914PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000257411

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEWRVDA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q581W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPNKTPVGD IKLDDNTETN YPINTSGGEP TENHADTDLD TQYKIHEYDT
60 70 80 90 100
RHAELKQRLM QIWGDDVEYV ARGEENANWL QKITYTWVKK YIRTAVKEEL
110 120 130 140 150
TLEGLPTAQS DHRAHKCGRQ LSAVTAESYY RRHLWDPIVG AGVSRRGDSQ
160 170 180 190 200
SRGTLRWVGV LQSGRYKEVM AAVTWQTPPL QRLSEHENGV SPFFSGAVHG
210 220 230 240 250
EVLFPPEASN NSTMEKPEDL QLLGCGSVSA NVVDQLAFPG RISAARNLFN
260 270 280 290 300
AKRGIILWQF PLRVLGDLLT LTVPLILKEY VRYLDAPSHT WGRGMLLAFG
310 320 330 340 350
LFVAHCVQSV VLHWFYHMGI KGGLCWRSAL SAVILEKCFV ISPKALALPE
360 370 380 390 400
MNTGRILNML TTDVERANEF VQLCLYLWSS PVIFIASTFL LYSLVGWSAL
410 420 430 440 450
VTVVVLPLTL TLNGYIVRQA MKIQRKIMKV ADSRVKATNE FISGIRIVKF
460 470 480 490 500
MAWEPSFIAA IEKQRDTELR YLRRLQRCHT LTSFLNNAMP PLTIAIVFVT
510 520 530 540 550
YHLLGNKLTP EVVFPTLMLL SVIRMPFLLL PMTLRTVTQF VISMKRVSVF
560 570 580 590 600
LECENTVKGV GDVTELLATQ KNAPPCWCEA AAVFDNAEVT ALFPVKLPRI
610 620 630 640 650
PTVVTSLCGR IMARLCCCGA CQPKRHSLSP LEVIDSEDEG EGSAQAGNEK
660 670 680 690 700
PPGRPGGNQK QPSPEETPRG VNKKVGEARY QLRPKKLLRD ISIEVPKGKL
710 720 730 740 750
TVVLGATGSG KSTLLETLLG NFEVTHGSVL AAKSFAYVPQ QPWIMNATLR
760 770 780 790 800
DNILFFTPEN EERLHKAVRV CQLEADLQQL PAGMETEIGE KGINLSGGQK
810 820 830 840 850
ARVSLARAVY ADRDFYILDD PLSALDAHVG ELIVRDLILG HLACKTRVLA
860 870 880 890 900
THQLHVLPHA DFVVAMEDGT VKFAGESKDF MRSPLCKKLA AEGCERKHEG
910 920 930 940 950
SSDREVDESD ILDGKPVHSN GNEPTQDGGN EGGEKKNTEA VDGRLTLMEE
960 970 980 990 1000
KAVGSVPWKT YKRYVGACGG GCKALLVIFT YFFTELLTVA ANLWLSMWST
1010 1020 1030 1040 1050
NKFKLDETTN LYVYLGIVIA GTISVPLRYT TTFGSMRHGS RTLHRFLLRS
1060 1070 1080 1090 1100
ISTGKMSFFD TTPLGRIVNR FSRDIDRLDN SLPMTFIFLM QVTFSIISAI
1110 1120 1130 1140 1150
AVYIGSQPYV LVALIPVCYV YYRLTLFYSA SNREIRRVGS TAKAPLMSLV
1160 1170 1180 1190 1200
GEALVGSSTI SAYGCQTAIM KKALAYIDLV YASSLLENAA NRWIGLRVEF
1210 1220 1230 1240 1250
LNTVVILVIA LTGVIGAMLG VDSHDIALVS LSLTMALMTT AALNWLVRMC
1260 1270 1280 1290 1300
GSMEADMNSV ERILYYTDNI ENEDMPELDE LVRAAKKAEE TTPRPKASSA
1310 1320 1330 1340 1350
TTTAVHVPVN GPVERNVVPG WVEFRDVDLR YRDGLPLVLN KVSFRVNPGQ
1360 1370 1380 1390 1400
KVGIVGRTGS GKSTLLLTFM RMIDTCGGEI IVSGRPIASY GLRELRQLFS
1410 1420 1430 1440 1450
MIPQDPVLFD GTVASNLDPF SQATPEEVWR ALELVGMRGH VAAESGGIEA
1460 1470 1480 1490 1500
RVQEGGLNYS VGQRQLLCLA RALLKRDSAF ILMDEATANI DHALDKQIQN
1510 1520 1530 1540 1550
TVRTAFANHT VITIAHRLHT VAQYDKIIVM DNGVVAECGA PRDLALSTSS
1560 1570 1580
KFRELLNSLG TNEVKNFMAV VEGAAASRSS G
Length:1,581
Mass (Da):174,682
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC55DE0B6C3F77EE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC091701 Genomic DNA Translation: AAX79437.1
CP000071 Genomic DNA Translation: AAZ12983.1

NCBI Reference Sequences

More...
RefSeqi
XP_847049.1, XM_841956.1

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
Tb927.8.2160:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3659201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tbr:Tb927.8.2160

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091701 Genomic DNA Translation: AAX79437.1
CP000071 Genomic DNA Translation: AAZ12983.1
RefSeqiXP_847049.1, XM_841956.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5691.AAZ12983

PTM databases

SwissPalmiQ581W6

Genome annotation databases

GeneDBiTb927.8.2160:pep
GeneIDi3659201
KEGGitbr:Tb927.8.2160

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.8.2160

Phylogenomic databases

HOGENOMiHOG000257411
OMAiNEWRVDA

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ581W6_TRYB2
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q581W6
Secondary accession number(s): D6XKV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 18, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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