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Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7SubstrateBy similarity1
Metal bindingi32Divalent metal cationBy similarity1
Active sitei34Proton acceptorBy similarity1
Metal bindingi34Divalent metal cationBy similarity1
Metal bindingi65Divalent metal cationBy similarity1
Binding sitei65SubstrateBy similarity1
Active sitei172Proton donorBy similarity1
Metal bindingi172Divalent metal cationBy similarity1
Binding sitei174Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-728-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:rpe
Ordered Locus Names:MJ0680
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001715841 – 234Ribulose-phosphate 3-epimeraseAdd BLAST234

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0680

Structurei

3D structure databases

ProteinModelPortaliQ58093
SMRiQ58093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 142Substrate bindingBy similarity4
Regioni194 – 195Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG05046 Archaea
COG0036 LUCA
InParanoidiQ58093
KOiK01783
OMAiCHLMIED
OrthoDBiPOG093Z0DBC
PhylomeDBiQ58093

Family and domain databases

CDDicd00429 RPE, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR026019 Ribul_P_3_epim
IPR000056 Ribul_P_3_epim-like
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR11749 PTHR11749, 1 hit
PfamiView protein in Pfam
PF00834 Ribul_P_3_epim, 1 hit
PIRSFiPIRSF001461 RPE, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01163 rpe, 1 hit
PROSITEiView protein in PROSITE
PS01085 RIBUL_P_3_EPIMER_1, 1 hit
PS01086 RIBUL_P_3_EPIMER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKIGASILS ADFGHLREEI KKAEEAGVDF FHVDMMDGHF VPNISMGIGI
60 70 80 90 100
AKHVKKLTEL PVEVHLMVEN VDLFVNEFEE MDYITFHIEA VKFPFRIINR
110 120 130 140 150
IKSIGAKPIV ALNPATPLDA IEYILGDVYA VLVMTVEPGF SGQKFIPVMT
160 170 180 190 200
KKIRKLKSMI VENGYDTKIF VDGGINVETA PLAVKAGADV LVAASAIFGK
210 220 230
DDVKTAVKNL REAALEALNK DFLTKSFNSN EEKQ
Length:234
Mass (Da):25,838
Last modified:November 1, 1996 - v1
Checksum:i070E2CF7A2BC9D7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98675.1
PIRiH64384
RefSeqiWP_010870185.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98675; AAB98675; MJ_0680
GeneIDi1451546
KEGGimja:MJ_0680

Similar proteinsi

Entry informationi

Entry nameiRPE_METJA
AccessioniPrimary (citable) accession number: Q58093
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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