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Protein

IMP cyclohydrolase

Gene

purO

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

pH dependencei

Optimum pH is 6-8.5.

Temperature dependencei

Fully active at 80 degrees Celsius. Gradually loses some activity from 90 to 100 degrees Celsius.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14617
MJAN243232:G1GKE-673-MONOMER
BRENDAi3.5.4.10 3260
UniPathwayi
UPA00074;UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
IMP synthase
Inosinicase
Gene namesi
Name:purO
Ordered Locus Names:MJ0626
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457951 – 202IMP cyclohydrolaseAdd BLAST202

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0626

Structurei

3D structure databases

ProteinModelPortaliQ58043
SMRiQ58043
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.Curated

Phylogenomic databases

eggNOGiarCOG04727 Archaea
COG3363 LUCA
InParanoidiQ58043
KOiK11176
OMAiSHVDPIA
OrthoDBiPOG093Z0CY5
PhylomeDBiQ58043

Family and domain databases

Gene3Di3.60.20.20, 1 hit
HAMAPiMF_00705 IMP_cyclohydrol, 1 hit
InterProiView protein in InterPro
IPR010191 IMP_cyclohydrolase
IPR020600 IMP_cyclohydrolase-like
IPR036795 IMP_cyclohydrolase-like_sf
PfamiView protein in Pfam
PF07826 IMP_cyclohyd, 1 hit
PIRSFiPIRSF004866 IMP_cclhdr_arch, 1 hit
SUPFAMiSSF75569 SSF75569, 1 hit
TIGRFAMsiTIGR01922 purO_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q58043-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYIGRFLVVG KTKEGKPFAA YRVSSRSFPN REAKKMDDNT VAIIPKDLNE
60 70 80 90 100
MFKNPYITYN CIKVIDKTIV VSNGTHTDFI AEKLHFGKRD ALAYVLAVMD
110 120 130 140 150
YEKDDYKTPR IAAILDENEC YMGYVAHDDI RVKKVELKDG KGYYLGVYNA
160 170 180 190 200
CKIDENQIID IKGETAEEIA DYILNYEEFE HPVACAVAVI DKDGIKIATK

GK
Length:202
Mass (Da):22,941
Last modified:September 9, 2003 - v2
Checksum:i339DDF505D0733D9
GO

Sequence cautioni

The sequence AAB98620 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98620.1 Different initiation.
PIRiB64378
RefSeqiWP_064496562.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98620; AAB98620; MJ_0626
GeneIDi1451492
KEGGimja:MJ_0626

Similar proteinsi

Entry informationi

Entry nameiPURO_METJA
AccessioniPrimary (citable) accession number: Q58043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 9, 2003
Last modified: March 28, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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