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Protein

Putative bifunctional cytochrome c-type biogenesis protein CcmAE

Gene

ccmAE

Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity).By similarity
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).By similarity

Caution

This sequence is a fusion of the duplicated copies ccmA2 and ccmE2, however, important parts of the proteins are missing and it is therefore probably not functional.Curated
Could be the product of a pseudogene.Curated

Catalytic activityi

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei307Heme (covalent; via pros nitrogen)By similarity1
Metal bindingi311Iron (heme axial ligand)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCytochrome c-type biogenesis, Transport
LigandATP-binding, Heme, Iron, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative bifunctional cytochrome c-type biogenesis protein CcmAE
Including the following 2 domains:
Cytochrome c biogenesis ATP-binding export protein CcmA 2 (EC:3.6.3.41)
Alternative name(s):
Heme exporter protein A 2
Cytochrome c-type biogenesis protein CcmE 2
Alternative name(s):
Cytochrome c maturation protein E 2
Heme chaperone CcmE 2
Gene namesi
Name:ccmAE
Synonyms:ccmA2, ccmE2
Ordered Locus Names:SCH_3737
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000000538 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002388601 – 336Putative bifunctional cytochrome c-type biogenesis protein CcmAEAdd BLAST336

Structurei

3D structure databases

ProteinModelPortaliQ57I19
SMRiQ57I19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 242ABC transporterAdd BLAST241

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 199Cytochrome c biogenesis ATP-binding export protein CcmA 2Add BLAST199
Regioni196 – 336Cytochrome c-type biogenesis protein CcmE 2Add BLAST141

Sequence similaritiesi

In the N-terminal section; belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]Curated
In the C-terminal section; belongs to the CcmE/CycJ family.Curated

Phylogenomic databases

KOiK02193

Family and domain databases

HAMAPiMF_01959 CcmE, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005895 ABC_transptr_haem_export_CcmA
IPR004329 CcmE
IPR036127 CcmE-like_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR43499 PTHR43499, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PF03100 CcmE, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF82093 SSF82093, 1 hit
TIGRFAMsiTIGR01189 ccmA, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51243 CCMA, 1 hit

Sequencei

Sequence statusi: Complete.

Q57I19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEARDLYCE RDERTLFRGL SFTVDAGEWV QVTGGNGAGK TTLLRLLTGL
60 70 80 90 100
ARPDGGEVYW QGEPLRRVRD SFHRSLLWIG HQPGIKTRLT ARENLHFFHP
110 120 130 140 150
GDGARLPEAL AQAGLAGFED VPVARLSAGQ QRRVALARLW LTRAALWVLD
160 170 180 190 200
EPFTAIDVNG VARLTRRMAA HTAQGGMVIL TTHQPLPGAA DTVRRLALTT
210 220 230 240 250
ALVLYALRAN IDLFYTPGEI LYGKRETQQL PAVGQRLRVG GMVMPGSVRR
260 270 280 290 300
DPDSLKVNFS LYDAEGSVTV SYEGILPDLF REGQGVVVQG TLEKGNHVLA
310 320 330
HEVLAKHDEN YTPPEVEKAM QENHRRPQRV DKDTSS
Length:336
Mass (Da):37,197
Last modified:May 30, 2006 - v2
Checksum:i26E359D6F50FB952
GO

Sequence cautioni

The sequence AAX67643 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017220 Genomic DNA Translation: AAX67643.1 Different initiation.
RefSeqiWP_024131381.1, NC_006905.1

Genome annotation databases

EnsemblBacteriaiAAX67643; AAX67643; SCH_3737
KEGGisec:SCH_3737

Similar proteinsi

Entry informationi

Entry nameiCCMAE_SALCH
AccessioniPrimary (citable) accession number: Q57I19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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