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Protein

Protein GrpE

Gene

grpE

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotationSAAS annotation
Biological processStress responseUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotationImported
Ordered Locus Names:BruAb1_0167Imported
OrganismiBrucella abortus biovar 1 (strain 9-941)Imported
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ57FK5
SMRiQ57FK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili37 – 89Sequence analysisAdd BLAST53

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000252083
KOiK03687
OMAiYAYEKIA

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q57FK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEKNKPEN PDLDQRDINN PRDREALKQA ADDFLKARRA EAAADEAEGE
60 70 80 90 100
VDETANRIAV LEADNTELKD QMLRVAAEME NLRKRTQRDV QDARAYAITN
110 120 130 140 150
FARDMLSVSD NLRRALDAIP ADALEADSNL KSLSEGVEMT ERAMLLALER
160 170 180 190 200
HGVKKLEPEG QKFDPNFHQA MFEVPNPDLP NNTVVQVVQA GYAIGDRVLR
210 220
PAMVGVSKGG PKVSAENGAS TSEDNA
Length:226
Mass (Da):24,883
Last modified:May 10, 2005 - v1
Checksum:iD5C09BBB3CD13644
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA Translation: AAX73579.1
RefSeqiWP_002965419.1, NC_006932.1

Genome annotation databases

EnsemblBacteriaiAAX73579; AAX73579; BruAb1_0167
GeneIDi29594650
KEGGibmb:BruAb1_0167

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA Translation: AAX73579.1
RefSeqiWP_002965419.1, NC_006932.1

3D structure databases

ProteinModelPortaliQ57FK5
SMRiQ57FK5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX73579; AAX73579; BruAb1_0167
GeneIDi29594650
KEGGibmb:BruAb1_0167

Phylogenomic databases

HOGENOMiHOG000252083
KOiK03687
OMAiYAYEKIA

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ57FK5_BRUAB
AccessioniPrimary (citable) accession number: Q57FK5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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