Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fructose-1,6-bisphosphate aldolase/phosphatase

Gene

fbp

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).UniRule annotation

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei17Proton acceptor; for FBP phosphatase activityUniRule annotation1
Metal bindingi17Magnesium 1UniRule annotation1
Metal bindingi24Magnesium 1; via pros nitrogenUniRule annotation1
Binding sitei24FBP; via tele nitrogenUniRule annotation1
Metal bindingi57Magnesium 1UniRule annotation1
Metal bindingi57Magnesium 2UniRule annotation1
Metal bindingi58Magnesium 2UniRule annotation1
Binding sitei95FBPUniRule annotation1
Metal bindingi99Magnesium 1UniRule annotation1
Metal bindingi136Magnesium 2UniRule annotation1
Binding sitei137FBP/DHAPUniRule annotation1
Active sitei233Proton donor/acceptor; for FBP aldolase activityUniRule annotation1
Active sitei236Schiff-base intermediate with DHAP; for FBP aldolase activityUniRule annotation1
Metal bindingi236Magnesium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi237Magnesium 3UniRule annotation1
Metal bindingi237Magnesium 4UniRule annotation1
Metal bindingi238Magnesium 2UniRule annotation1
Metal bindingi238Magnesium 3UniRule annotation1
Binding sitei270FBP/DHAP; via amide nitrogenUniRule annotation1
Binding sitei291FBP/DHAPUniRule annotation1
Binding sitei352FBPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Lyase
Biological processCarbohydrate metabolism, Gluconeogenesis
LigandMagnesium, Metal-binding, Schiff base

Enzyme and pathway databases

UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphate aldolase/phosphataseUniRule annotation (EC:3.1.3.11UniRule annotation, EC:4.1.2.13UniRule annotation)
Short name:
FBP A/PUniRule annotation
Short name:
FBP aldolase/phosphataseUniRule annotation
Gene namesi
Name:fbpUniRule annotation
Ordered Locus Names:MJ0299
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001067821 – 389Fructose-1,6-bisphosphate aldolase/phosphataseAdd BLAST389

Interactioni

Subunit structurei

Homooctamer; dimer of tetramers.UniRule annotation

Protein-protein interaction databases

STRINGi243232.MJ_0299

Structurei

3D structure databases

ProteinModelPortaliQ57747
SMRiQ57747
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 109FBP bindingUniRule annotation2
Regioni246 – 247FBP binding; shared with dimeric partnerUniRule annotation2

Domaini

Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.UniRule annotation

Sequence similaritiesi

Belongs to the FBP aldolase/phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04180 Archaea
COG1980 LUCA
InParanoidiQ57747
KOiK01622
OMAiYMRRHGP
OrthoDBiPOG093Z0396
PhylomeDBiQ57747

Family and domain databases

HAMAPiMF_02067 FBP_aldolase_phosphatase, 1 hit
InterProiView protein in InterPro
IPR002803 FBPase_V
IPR036076 FBPase_V_sf
PANTHERiPTHR38341 PTHR38341, 1 hit
PfamiView protein in Pfam
PF01950 FBPase_3, 1 hit
PIRSFiPIRSF015647 FBPtase_archl, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014260 FBPase_V, 1 hit
SUPFAMiSSF111249 SSF111249, 1 hit

Sequencei

Sequence statusi: Complete.

Q57747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRMENNKVT ISVIKADVGG LCGHTLAPDE LLEACEAVLE EAVDEIILDY
60 70 80 90 100
YVTRCGDDID LIMSHKLGCD NEKVHGLAWR AFEEATKVAK ELKLYGAGQD
110 120 130 140 150
LLADSFSGNV RGMGPGCAEM EFVERKSEPI VVFCCDKTDP TAFNYPLFKM
160 170 180 190 200
FADPFNTAGL VFDPSMISGF KFEVHDVVGH KKVFLDTPEE MYMLLALIGD
210 220 230 240 250
YEKYAIKRVY RRRDNEIAAV VSTEKLNYIA GEYVGKDDPV AIVRAQSGFP
260 270 280 290 300
AVGEVLEPFA NPHFVPGWMR GSHWGPLMPV GEEDATPTRF DGPARIIALG
310 320 330 340 350
FQVCDGMLIG PNDLFADKGF DKAREKALEM ADIIRRMGPF QPHRLPATMM
360 370 380
EYTTVPKVLE ALEDRFIPLE GLELIEEGGI TRKDRGDVE
Length:389
Mass (Da):43,246
Last modified:November 1, 1996 - v1
Checksum:i1BB8D890F931CE73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98286.1
PIRiD64337

Genome annotation databases

EnsemblBacteriaiAAB98286; AAB98286; MJ_0299
KEGGimja:MJ_0299

Similar proteinsi

Entry informationi

Entry nameiFBPAP_METJA
AccessioniPrimary (citable) accession number: Q57747
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health