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Entry version 132 (07 Apr 2021)
Sequence version 2 (28 Jun 2011)
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Protein

dITP/XTP pyrophosphatase

Gene

MJ0226

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides xanthosine triphosphate (XTP), deoxyinosine triphosphate (dITP) and ITP (PubMed:10404228, PubMed:11452035). Probably functions as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions (PubMed:11452035). Shows very low activity on GTP or dGTP, both of which are hydrolyzed more than 100-fold less efficiently than XTP, and has nearly no activity toward the canonical nucleotides ATP, CTP, and TTP, and toward 6-N-hydroxylaminopurine deoxynucleoside triphosphate (dHAPTP) (PubMed:10404228, PubMed:11452035). Displays neither endonuclease nor 3'-exonuclease activities (PubMed:11452035).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 PublicationsNote: Binds 1 Mg2+ ion per subunit (By similarity). Magnesium ions are required for optimal activity, with Mn2+, Zn2+ and Ni2+ supporting <50% of the maximum rate (PubMed:11452035).UniRule annotation2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 1009 sec(-1) with XTP as substrate. kcat is 911.7 sec(-1) with ITP as substrate. kcat is 97.6 sec(-1) with GTP as substrate. kcat is 96.6 sec(-1) with dGTP as substrate (at pH 7.6 and 80 degrees Celsius) (PubMed:10404228). kcat is 176.4 sec(-1) with XTP as substrate. kcat is 152.4 sec(-1) with dITP as substrate. kcat is 155.8 sec(-1) with ITP as substrate. kcat is 9.3 sec(-1) with dGTP as substrate. kcat is 9.1 sec(-1) with GTP as substrate. kcat is 8.2 sec(-1) with 3'dGTP as substrate. kcat is 3.3 sec(-1) with ddGTP as substrate. kcat is 0.44 sec(-1) with dATP as substrate. kcat is 0.44 sec(-1) with dCTP as substrate. kcat is 1.8 sec(-1) with dTTP as substrate. kcat is 5.8 sec(-1) with dUTP as substrate. kcat is 2.4 sec(-1) with 8-oxo-dGTP as substrate. kcat is 1.8 sec(-1) with dHAPTP as substrate (at pH 10.5 and 80 degrees Celsius) (PubMed:11452035).2 Publications
  1. KM=0.10 mM for XTP (at pH 7.6 and 80 degrees Celsius)1 Publication
  2. KM=0.15 mM for ITP (at pH 7.6 and 80 degrees Celsius)1 Publication
  3. KM=1.11 mM for GTP (at pH 7.6 and 80 degrees Celsius)1 Publication
  4. KM=1.13 mM for dGTP (at pH 7.6 and 80 degrees Celsius)1 Publication
  5. KM=0.22 mM for XTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  6. KM=0.25 mM for dITP (at pH 10.5 and 80 degrees Celsius)1 Publication
  7. KM=0.24 mM for ITP (at pH 10.5 and 80 degrees Celsius)1 Publication
  8. KM=2.12 mM for dGTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  9. KM=1.94 mM for GTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  10. KM=2.87 mM for 3'dGTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  11. KM=2.78 mM for ddGTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  12. KM=7.3 mM for dATP (at pH 10.5 and 80 degrees Celsius)1 Publication
  13. KM=5.47 mM for dCTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  14. KM=4.4 mM for dTTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  15. KM=4.22 mM for dUTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  16. KM=5.3 mM for 8-oxo-dGTP (at pH 10.5 and 80 degrees Celsius)1 Publication
  17. KM=3.3 mM for dHAPTP (at pH 10.5 and 80 degrees Celsius)1 Publication

    pH dependencei

    Optimum pH is 10.5 with dITP as substrate. The reaction rates under neutral conditions are <30% of maximum.1 Publication

    Temperature dependencei

    Optimum temperature is 80 degrees Celsius. At low temperature (30 degrees Celsius), shows about 5-fold decrease in activity compared to the maximum activity at 80 degrees Celsius. Is highly thermostable. The half-life of the protein at 95 degrees Celsius is about 200 minutes.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi37MagnesiumUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei65Proton acceptorUniRule annotation1
    Metal bindingi65MagnesiumUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei66Substrate; via amide nitrogenUniRule annotation1
    Binding sitei164SubstrateUniRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processNucleotide metabolism
    LigandMagnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MJAN243232:G1GKE-240-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.6.1.66, 3260
    3.6.1.B14, 3260

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q57679

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    dITP/XTP pyrophosphatase1 Publication (EC:3.6.1.661 Publication)
    Alternative name(s):
    Hypoxanthine/xanthine dNTP pyrophosphatase1 Publication
    Non-canonical purine NTP pyrophosphatase1 Publication
    Non-standard purine NTP pyrophosphatase1 Publication
    Nucleoside-triphosphate diphosphatase1 Publication
    Nucleoside-triphosphate pyrophosphatase1 Publication
    Short name:
    NTPase1 Publication
    Nucleotide triphosphatase1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Ordered Locus Names:MJ0226
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243232 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001782741 – 185dITP/XTP pyrophosphataseAdd BLAST185

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    243232.MJ_0226

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1185
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q57679

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q57679

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni7 – 12Substrate bindingUniRule annotation6
    Regioni141 – 144Substrate bindingUniRule annotation4
    Regioni169 – 170Substrate bindingUniRule annotationCombined sources1 Publication2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the HAM1 NTPase family.UniRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    arCOG04184, Archaea

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_082080_1_0_2

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q57679

    Database of Orthologous Groups

    More...
    OrthoDBi
    94889at2157

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00515, HAM1, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.950.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01405, Non_canon_purine_NTPase, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020922, dITP/XTP_pyrophosphatase
    IPR002637, Ham1p-like
    IPR029001, ITPase-like_fam

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11067, PTHR11067, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01725, Ham1p_like, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52972, SSF52972, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00042, TIGR00042, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q57679-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKIYFATGNP NKIKEANIIL KDLKDVEIEQ IKISYPEIQG TLEEVAEFGA
    60 70 80 90 100
    KWVYNILKKP VIVEDSGFFV EALNGFPGTY SKFVQETIGN EGILKLLEGK
    110 120 130 140 150
    DNRNAYFKTV IGYCDENGVR LFKGIVKGRV SEEIRSKGYG FAYDSIFIPE
    160 170 180
    EEERTFAEMT TEEKSQISHR KKAFEEFKKF LLDRI
    Length:185
    Mass (Da):21,273
    Last modified:June 28, 2011 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97EC2DA5C0D21D67
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAB98211 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L77117 Genomic DNA Translation: AAB98211.1 Different initiation.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    C64328

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_064496428.1, NC_000909.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAB98211; AAB98211; MJ_0226

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1451077

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mja:MJ_0226

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L77117 Genomic DNA Translation: AAB98211.1 Different initiation.
    PIRiC64328
    RefSeqiWP_064496428.1, NC_000909.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1B78X-ray2.20A/B1-185[»]
    2MJPX-ray2.20A/B1-185[»]
    SMRiQ57679
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    STRINGi243232.MJ_0226

    Genome annotation databases

    EnsemblBacteriaiAAB98211; AAB98211; MJ_0226
    GeneIDi1451077
    KEGGimja:MJ_0226

    Phylogenomic databases

    eggNOGiarCOG04184, Archaea
    HOGENOMiCLU_082080_1_0_2
    InParanoidiQ57679
    OrthoDBi94889at2157

    Enzyme and pathway databases

    BioCyciMJAN243232:G1GKE-240-MONOMER
    BRENDAi3.6.1.66, 3260
    3.6.1.B14, 3260
    SABIO-RKiQ57679

    Miscellaneous databases

    EvolutionaryTraceiQ57679

    Family and domain databases

    CDDicd00515, HAM1, 1 hit
    Gene3Di3.90.950.10, 1 hit
    HAMAPiMF_01405, Non_canon_purine_NTPase, 1 hit
    InterProiView protein in InterPro
    IPR020922, dITP/XTP_pyrophosphatase
    IPR002637, Ham1p-like
    IPR029001, ITPase-like_fam
    PANTHERiPTHR11067, PTHR11067, 1 hit
    PfamiView protein in Pfam
    PF01725, Ham1p_like, 1 hit
    SUPFAMiSSF52972, SSF52972, 1 hit
    TIGRFAMsiTIGR00042, TIGR00042, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIXTPA_METJA
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q57679
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 28, 2011
    Last modified: April 7, 2021
    This is version 132 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
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