Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 117 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Dimethyl sulfoxide/trimethylamine N-oxide reductase

Gene

dmsA

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO) to dimethyl sulfide (DMS) and trimethylamine, respectively. The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to DMSO and TMAO.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mo-bis(molybdopterin guanine dinucleotide)3 PublicationsNote: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei158Molybdopterin guanine dinucleotide 21
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi189Molybdenum1
Binding sitei368Molybdopterin guanine dinucleotide 11
Binding sitei476Molybdopterin guanine dinucleotide 11
Binding sitei480Molybdopterin guanine dinucleotide 11
Binding sitei523Molybdopterin guanine dinucleotide 11
Binding sitei553Molybdopterin guanine dinucleotide 11
Binding sitei689Molybdopterin guanine dinucleotide 11
Binding sitei779Molybdopterin guanine dinucleotide 11

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, Molybdenum

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dimethyl sulfoxide/trimethylamine N-oxide reductase (EC:1.7.2.3, EC:1.8.5.3)
Short name:
DMSO reductase
Short name:
DMSOR
Short name:
Me2SO reductase
Short name:
TMAOR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dmsA
Synonyms:dsrA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1063 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeLuteovulum

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Periplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Disruption of dmsA results in the inability to use DMSO or TMAO as the terminal electron acceptor in anaerobic respiration and in greatly diminished in vitro DMSOR activity.1 Publication

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02153, 3-sulfino-L-alanine
DB02379, Beta-D-Glucose

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 42Tat-type signalPROSITE-ProRule annotation2 PublicationsAdd BLAST42
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001914643 – 822Dimethyl sulfoxide/trimethylamine N-oxide reductaseAdd BLAST780

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1822
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q57366

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q57366

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni158 – 160MGD 1 binding3
Regioni232 – 233MGD 2 binding2
Regioni262 – 263MGD 2 binding2
Regioni283 – 285MGD 2 binding3
Regioni364 – 365MGD 2 binding2
Regioni500 – 501MGD 1 binding2
Regioni683 – 686MGD 1 binding4
Regioni691 – 693MGD 1 binding3
Regioni796 – 797MGD 1 binding2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02793, MopB_CT_DMSOR-BSOR-TMAOR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR006658, BisC
IPR041954, CT_DMSOR/BSOR/TMAOR
IPR041460, Molybdopterin_N
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006655, Mopterin_OxRdtase_prok_CS
IPR006311, TAT_signal
IPR019546, TAT_signal_bac_arc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00384, Molybdopterin, 1 hit
PF18364, Molybdopterin_N, 1 hit
PF01568, Molydop_binding, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50692, SSF50692, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00509, bisC_fam, 1 hit
TIGR01409, TAT_signal_seq, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00490, MOLYBDOPTERIN_PROK_2, 1 hit
PS00932, MOLYBDOPTERIN_PROK_3, 1 hit
PS51318, TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q57366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKLSGQELH AELSRRAFLS YTAAVGALGL CGTSLLAQGA RAEGLANGEV
60 70 80 90 100
MSGCHWGVFK ARVENGRAVA FEPWDKDPAP SHQLPGVLDS IYSPTRIKYP
110 120 130 140 150
MVRREFLEKG VNADRSTRGN GDFVRVTWDE ALDLVARELK RVQESYGPTG
160 170 180 190 200
TFGGSYGWKS PGRLHNCQVL MRRALNLAGG FVNSSGDYST AAAQIIMPHV
210 220 230 240 250
MGTLEVYEQQ TAWPVVVENT DLMVFWAADP MKTNEIGWVI PDHGAYAGMK
260 270 280 290 300
ALKEKGTRVI CINPVRTETA DYFGADVVSP RPQTDVALML GMAHTLYSED
310 320 330 340 350
LHDKDFLENC TTGFDLFAAY LTGESDGTPK TAEWAAEICG LPAEQIRELA
360 370 380 390 400
RSFVAGRTML AAGWSIQRMH HGEQAHWMLV TLASMIGQIG LPGGGFGLSY
410 420 430 440 450
HYSNGGSPTS DGPALGGISD GGKAVEGAAW LSESGATSIP CARVVDMLLN
460 470 480 490 500
PGGEFQFNGA TATYPDVKLA YWAGGNPFAH HQDRNRMLKA WEKLETFIVQ
510 520 530 540 550
DFQWTATARH ADIVLPATTS YERNDIESVG DYSNRAILAM KKVVDPLYEA
560 570 580 590 600
RSDYDIFAAL AERLGKGAEF TEGRDEMGWI SSFYEAAVKQ AEFKNVAMPS
610 620 630 640 650
FEDFWSEGIV EFPITEGANF VRYADFREDP LFNPLGTPSG LIEIYSKNIE
660 670 680 690 700
KMGYDDCPAH PTWMEPAERL GGAGAKYPLH VVASHPKSRL HSQLNGTSLR
710 720 730 740 750
DLYAVAGHEP CLINPADAAA RGIADGDVLR VFNDRGQILV GAKVSDAVMP
760 770 780 790 800
GAIQIYEGGW YDPLDPSEEG TLDKYGDVNV LSLDVGTSKL AQGNCGQTIL
810 820
ADVEKYAGAP VTVTVFDTPK GA
Length:822
Mass (Da):89,208
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AB3497E5D26B1C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti185S → V in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti192A → G in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti199H → Y in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti371 – 373HGE → MAQ in AAC13660 (PubMed:7625833).Curated3
Sequence conflicti422G → A in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti430W → C in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti695N → T in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti706A → V in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti742A → T in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti749M → I in AAC13660 (PubMed:7625833).Curated1
Sequence conflicti793G → D in AAC13660 (PubMed:7625833).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L46851 Genomic DNA Translation: AAB07230.1
D38634 Genomic DNA Translation: BAA07615.1
U25037 Genomic DNA Translation: AAC13660.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S70012

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L46851 Genomic DNA Translation: AAB07230.1
D38634 Genomic DNA Translation: BAA07615.1
U25037 Genomic DNA Translation: AAC13660.1
PIRiS70012

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EU1X-ray1.30A43-822[»]
SMRiQ57366
ModBaseiSearch...
PDBe-KBiSearch...

Chemistry databases

DrugBankiDB02153, 3-sulfino-L-alanine
DB02379, Beta-D-Glucose

Miscellaneous databases

EvolutionaryTraceiQ57366

Family and domain databases

CDDicd02793, MopB_CT_DMSOR-BSOR-TMAOR, 1 hit
InterProiView protein in InterPro
IPR009010, Asp_de-COase-like_dom_sf
IPR006658, BisC
IPR041954, CT_DMSOR/BSOR/TMAOR
IPR041460, Molybdopterin_N
IPR006657, MoPterin_dinucl-bd_dom
IPR006656, Mopterin_OxRdtase
IPR006655, Mopterin_OxRdtase_prok_CS
IPR006311, TAT_signal
IPR019546, TAT_signal_bac_arc
PfamiView protein in Pfam
PF00384, Molybdopterin, 1 hit
PF18364, Molybdopterin_N, 1 hit
PF01568, Molydop_binding, 1 hit
SUPFAMiSSF50692, SSF50692, 1 hit
TIGRFAMsiTIGR00509, bisC_fam, 1 hit
TIGR01409, TAT_signal_seq, 1 hit
PROSITEiView protein in PROSITE
PS00490, MOLYBDOPTERIN_PROK_2, 1 hit
PS00932, MOLYBDOPTERIN_PROK_3, 1 hit
PS51318, TAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSTOR_RHOSH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q57366
Secondary accession number(s): Q53077
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again