Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 354C

Gene

Znf354c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354C
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 3
Gene namesi
Name:Znf354c
Synonyms:Kiaa4218, Kid3, Zfp354c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353621 Zfp354c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804091 – 560Zinc finger protein 354CAdd BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ571J5
PaxDbiQ571J5
PeptideAtlasiQ571J5
PRIDEiQ571J5

PTM databases

iPTMnetiQ571J5
PhosphoSitePlusiQ571J5
SwissPalmiQ571J5

Expressioni

Tissue specificityi

Expressed in brain. Lower levels in kidney, heart, lung, spleen and eye. Down-regulated during kidney maturation. Expressed in embryonic myogenic progenitor cells, not expressed in adult and aged satellite cells (PubMed:27446912).2 Publications

Developmental stagei

In myogenic progenitor cells, expressed during early myogenic development (E11.5) to be gradually down-regulated during the fetal stages (from E14.5 to adulthood).1 Publication

Gene expression databases

BgeeiENSMUSG00000044807 Expressed in 218 organ(s), highest expression level in central nervous system
CleanExiMM_ZFP354C
GenevisibleiQ571J5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000632

Structurei

3D structure databases

ProteinModelPortaliQ571J5
SMRiQ571J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 84KRABPROSITE-ProRule annotationAdd BLAST71

Domaini

KRAB domain is not required for nuclear targeting or for DNA binding.By similarity
Zinc finger region is involved in nuclear targeting and DNA-binding.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144323
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ571J5
KOiK09228
OMAiCFQIYPG
OrthoDBiEOG091G02KC
PhylomeDBiQ571J5
TreeFamiTF350822

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

Q571J5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVDLLAARG TEPVTFRDVA VSFSQDEWLH LDPAQRSLYR EVMLENYSNL
60 70 80 90 100
ASLGFQASIP PVIGKLQKGQ DPCMEREAPE DTCLDFEIWP EIEALPPKQD
110 120 130 140 150
VLTKETSHGL IKNGSTKCVY WKISFGELVK TECRDIAQEQ EKKVHGPGAE
160 170 180 190 200
SPKETTSEDG TPTGFEPEKP LFISKALVSQ EGDPTESVPA TYHTSEKDLP
210 220 230 240 250
QDFDLMRSFQ MYPGQKPHVC SECGKGFTQS LHLLEHKRLH TGEKPYKCSE
260 270 280 290 300
CGKSFSHRSS LLAHQRTHTG EKPYKCSECE KAFGSSSTLI KHLRVHTGEK
310 320 330 340 350
PYRCRQCGKA FSQCSTLTVH QRIHTGEKLY KCAECDKAFN CRAKLHRHQR
360 370 380 390 400
IHTGEKPYKC AECGKGYSQF PSLAEHQRLH TGEQLCQCLQ CGRTFTRVST
410 420 430 440 450
LIEHQRIHTG QKPYQCNECG KTFNQYSSFN EHRKIHTGEK LYTCEECGKA
460 470 480 490 500
FGCKSNLYRH QRIHTGEKPY QCNQCGKAFS QYSFLTEHER IHTGEKLYKC
510 520 530 540 550
MECGKAYSYR SNLCRHKKVH LKERLYKWKE YGTPFIYGSS LTPYQKFLKG
560
DKPENFNSSL
Length:560
Mass (Da):64,065
Last modified:March 20, 2007 - v2
Checksum:iA348B1C5C9392A22
GO

Sequence cautioni

The sequence BAD90379 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77E → K in BAC39738 (PubMed:16141072).Curated1
Sequence conflicti87E → K in BAE26722 (PubMed:16141072).Curated1
Sequence conflicti284G → D in BAE26722 (PubMed:16141072).Curated1
Sequence conflicti287S → P in BAE26722 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192804 mRNA Translation: AAF35173.1
AK086760 mRNA Translation: BAC39738.1
AK145882 mRNA Translation: BAE26722.1
AK220194 mRNA Translation: BAD90379.1 Different initiation.
AL627215 Genomic DNA No translation available.
BC079908 mRNA Translation: AAH79908.1
CCDSiCCDS24637.1
RefSeqiNP_038950.3, NM_013922.4
UniGeneiMm.103674

Genome annotation databases

EnsembliENSMUST00000000632; ENSMUSP00000000632; ENSMUSG00000044807
ENSMUST00000109135; ENSMUSP00000104763; ENSMUSG00000044807
GeneIDi30944
KEGGimmu:30944
UCSCiuc007isq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192804 mRNA Translation: AAF35173.1
AK086760 mRNA Translation: BAC39738.1
AK145882 mRNA Translation: BAE26722.1
AK220194 mRNA Translation: BAD90379.1 Different initiation.
AL627215 Genomic DNA No translation available.
BC079908 mRNA Translation: AAH79908.1
CCDSiCCDS24637.1
RefSeqiNP_038950.3, NM_013922.4
UniGeneiMm.103674

3D structure databases

ProteinModelPortaliQ571J5
SMRiQ571J5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000632

PTM databases

iPTMnetiQ571J5
PhosphoSitePlusiQ571J5
SwissPalmiQ571J5

Proteomic databases

MaxQBiQ571J5
PaxDbiQ571J5
PeptideAtlasiQ571J5
PRIDEiQ571J5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000632; ENSMUSP00000000632; ENSMUSG00000044807
ENSMUST00000109135; ENSMUSP00000104763; ENSMUSG00000044807
GeneIDi30944
KEGGimmu:30944
UCSCiuc007isq.1 mouse

Organism-specific databases

CTDi30944
MGIiMGI:1353621 Zfp354c
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144323
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ571J5
KOiK09228
OMAiCFQIYPG
OrthoDBiEOG091G02KC
PhylomeDBiQ571J5
TreeFamiTF350822

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:Q571J5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044807 Expressed in 218 organ(s), highest expression level in central nervous system
CleanExiMM_ZFP354C
GenevisibleiQ571J5 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZ354C_MOUSE
AccessioniPrimary (citable) accession number: Q571J5
Secondary accession number(s): Q3UKS9, Q8C365, Q9JLD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: October 10, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again