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Entry version 99 (11 Dec 2019)
Sequence version 1 (10 May 2005)
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Protein
Submitted name:

MKIAA4226 protein

Gene

Fbn2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA4226 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fbn2Imported
Synonyms:mKIAA4226Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95490 Fbn2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 177PROSITE-ProRule annotation
Disulfide bondi1249 ↔ 1259PROSITE-ProRule annotation
Disulfide bondi1929 ↔ 1939PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q571J3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 67TBInterPro annotationAdd BLAST53
Domaini79 – 120EGF-likeInterPro annotationAdd BLAST42
Domaini121 – 162EGF-likeInterPro annotationAdd BLAST42
Domaini163 – 202EGF-likeInterPro annotationAdd BLAST40
Domaini207 – 246TBInterPro annotationAdd BLAST40
Domaini266 – 307EGF-likeInterPro annotationAdd BLAST42
Domaini312 – 363TBInterPro annotationAdd BLAST52
Domaini384 – 425EGF-likeInterPro annotationAdd BLAST42
Domaini426 – 468EGF-likeInterPro annotationAdd BLAST43
Domaini469 – 510EGF-likeInterPro annotationAdd BLAST42
Domaini511 – 552EGF-likeInterPro annotationAdd BLAST42
Domaini553 – 593EGF-likeInterPro annotationAdd BLAST41
Domaini594 – 635EGF-likeInterPro annotationAdd BLAST42
Domaini636 – 673EGF-likeInterPro annotationAdd BLAST38
Domaini678 – 718EGF-likeInterPro annotationAdd BLAST41
Domaini719 – 759EGF-likeInterPro annotationAdd BLAST41
Domaini760 – 801EGF-likeInterPro annotationAdd BLAST42
Domaini802 – 838EGF-likeInterPro annotationAdd BLAST37
Domaini843 – 883EGF-likeInterPro annotationAdd BLAST41
Domaini888 – 944TBInterPro annotationAdd BLAST57
Domaini961 – 1002EGF-likeInterPro annotationAdd BLAST42
Domaini1003 – 1044EGF-likeInterPro annotationAdd BLAST42
Domaini1049 – 1102TBInterPro annotationAdd BLAST54
Domaini1119 – 1160EGF-likeInterPro annotationAdd BLAST42
Domaini1161 – 1202EGF-likeInterPro annotationAdd BLAST42
Domaini1203 – 1240EGF-likeInterPro annotationAdd BLAST38
Domaini1245 – 1280EGF-likeInterPro annotationAdd BLAST36
Domaini1284 – 1326EGF-likeInterPro annotationAdd BLAST43
Domaini1327 – 1366EGF-likeInterPro annotationAdd BLAST40
Domaini1367 – 1408EGF-likeInterPro annotationAdd BLAST42
Domaini1413 – 1466TBInterPro annotationAdd BLAST54
Domaini1482 – 1523EGF-likeInterPro annotationAdd BLAST42
Domaini1524 – 1563EGF-likeInterPro annotationAdd BLAST40
Domaini1564 – 1600EGF-likeInterPro annotationAdd BLAST37
Domaini1605 – 1648EGF-likeInterPro annotationAdd BLAST44
Domaini1649 – 1686EGF-likeInterPro annotationAdd BLAST38
Domaini1695 – 1748TBInterPro annotationAdd BLAST54
Domaini1760 – 1797EGF-likeInterPro annotationAdd BLAST38
Domaini1802 – 1842EGF-likeInterPro annotationAdd BLAST41
Domaini1843 – 1879EGF-likeInterPro annotationAdd BLAST37
Domaini1882 – 1924EGF-likeInterPro annotationAdd BLAST43
Domaini1925 – 1964EGF-likeInterPro annotationAdd BLAST40
Domaini1965 – 2001EGF-likeInterPro annotationAdd BLAST37
Domaini2006 – 2045EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7H Eukaryota
ENOG410XSTY LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 35 hits
PF00683 TB, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 37 hits
SM00179 EGF_CA, 37 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 9 hits
SSF57581 SSF57581, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 37 hits
PS01186 EGF_2, 21 hits
PS50026 EGF_3, 37 hits
PS01187 EGF_CA, 13 hits
PS51364 TB, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q571J3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VGVDGRVCVD THMRSTCYGE IKKGVCVRPF PGAVTKSECC CANPDYGFGE
60 70 80 90 100
PCQPCPAKNS AEFHGLCSSG IGITVDGRDI NECALDPDIC ANGICENLRG
110 120 130 140 150
SYRCNCNSGY EPDASGRNCI DIDECLVNRL LCDNGLCRNT PGSYSCTCPP
160 170 180 190 200
GYVFRTETET CEDVNECESN PCVNGACRNN LGSFHCECSP GSKLSSTGLI
210 220 230 240 250
CIDSLKGTCW LNIQDNRCEV NINGATLKSE CCATLGAAWG SPCERCELDA
260 270 280 290 300
ACPRGFARIK GVTCEDVNEC EVFPGVCPNG RCVNSKGSFH CECPEGLTLD
310 320 330 340 350
GTGRVCLDIR MEHCFLKWDE DECIHPVPGK FRMDACCCAV GAAWGTECEE
360 370 380 390 400
CPKPGTKEYE TLCPRGPGFA NRGDILTGRP FYKDINECKA FPGMCTYGKC
410 420 430 440 450
RNTIGSFKCR CNNGFALDME ERNCTDIDEC RISPDLCGSG ICVNTPGSFE
460 470 480 490 500
CECFEGYESG FMMMKNCMDI DECERNPLLC RGGTCVNTEG SFQCDCPLGH
510 520 530 540 550
ELSPSREDCV DINECSLSDN LCRNGKCVNM IGTYQCSCNP GYQATPDRQG
560 570 580 590 600
CTDIDECMIM NGGCDTQCTN SEGSYECSCS EGYALMPDGR SCADIDECEN
610 620 630 640 650
NPDICDGGQC TNIPGEYRCL CYDGFMASMD MKTCIDVNEC DLNPNICMFG
660 670 680 690 700
ECENTKGSFI CHCQLGYSVK KGTTGCTDVD ECEIGAHNCD MHASCLNVPG
710 720 730 740 750
SFKCSCREGW VGNGIKCIDL DECANGTHQC SINAQCVNTP GSYRCACSEG
760 770 780 790 800
FTGDGFTCSD VDECAENTNL CENGQCLNVP GAYRCECEMG FTPASDSRSC
810 820 830 840 850
QDIDECSFQN ICVFGTCNNL PGMFHCICDD GYELDRTGGN CTDIDECADP
860 870 880 890 900
INCVNGLCVN TPGRYECNCP PDFQLNPTGV GCVDNRVGNC YLKFGPRGDG
910 920 930 940 950
SLSCNTEVGV GVSRSSCCCS LGKAWGNPCE TCPPVNSTEY YTLCPGGEGF
960 970 980 990 1000
RPNPITIILE DIDECQELPG LCQGGNCINT FGSFQCECPQ GYYLSEETRI
1010 1020 1030 1040 1050
CEDIDECFAH PGVCGPGTCY NTLGNYTCIC PPEYMQVNGG HNCMDMRKSF
1060 1070 1080 1090 1100
CYRSYNGTTC ENELPFNVTK RMCCCTYNVG KAWNKPCEPC PTPGTADFKT
1110 1120 1130 1140 1150
ICGNIPGFTF DIHTGKAVDI DECKEIPGIC ANGVCINQIG SFRCECPTGF
1160 1170 1180 1190 1200
SYNDLLLVCE DIDECSNGDN LCQRNADCIN SPGSYRCECA AGFKLSPNGA
1210 1220 1230 1240 1250
CVDRNECLEI PNVCSHGLCV DLQGSYQCIC NNGFKASQDQ TMCMDVDECE
1260 1270 1280 1290 1300
RHPCGNGTCK NTVGSYNCLC YPGFELTHNN DCLDIDECSS FFGQVCRNGR
1310 1320 1330 1340 1350
CFNEIGSFKC LCNEGYELTP DGKNCIDTNE CVALPGSCSP GTCQNLEGSF
1360 1370 1380 1390 1400
RCICPPGYEV RSENCIDINE CDEDPNICLF GSCTNTPGGF QCICPPGFVL
1410 1420 1430 1440 1450
SDNGRRCFDT RQSFCFTNFE NGKCSVPKAF NTTKAKCCCS KMPGEGWGDP
1460 1470 1480 1490 1500
CELCPKDDEV AFQDLCPYGH GTVPSLHDTR EDVNECLESP GICSNGQCIN
1510 1520 1530 1540 1550
TDGSFRCECP MGYNLDYTGV RCVDTDECSI GNPCGNGTCT NVIGSFECTC
1560 1570 1580 1590 1600
NEGFEPGPMM NCEDINECAQ NPLLCAFRCM NTFGSYECTC PVGYALREDQ
1610 1620 1630 1640 1650
KMCKDLDECA EGLHDCESRG MMCKNLIGTF MCICPPGMAR RPDGEGCVDE
1660 1670 1680 1690 1700
NECRTKPGIC ENGRCVNIIG SYRCECNEGF QSSSSGTECL DNRQGLCFAE
1710 1720 1730 1740 1750
VLQTMCQMAS SSRNLVTKSE CCCDGGRGWG HQCELCPLPG TAQYKKICPH
1760 1770 1780 1790 1800
GPGYATDGRD IDECKVMPSL CTNGQCVNTM GSFRCFCKVG YTTDISGTAC
1810 1820 1830 1840 1850
VDLDECSQSP KPCNFICKNT EGSYQCSCPR GYVLQEDGKT CKDLDECQTK
1860 1870 1880 1890 1900
QHNCQFLCVN TLGGFTCKCP PGFTQHHTAC IDNNECGSQP SLCGAKGICQ
1910 1920 1930 1940 1950
NTPGSFSCEC QRGFSLDASG LNCEDVDECD GNHRCQHGCQ NILGGYRCGC
1960 1970 1980 1990 2000
PQGYVQHYQW NQCVDENECS NPGACGSASC YNTLGSYKCA CPSGFSFDQF
2010 2020 2030 2040 2050
SSACHDVNEC SSSKNPCSYG CSNTEGGYLC GCPPGYFRVG QGHCVSGMGF
2060 2070 2080 2090 2100
NKGQYLSVDA EAEDDENALS PEACYECKIN GYTKKDGRRK RSAQEPEPAS
2110 2120 2130 2140 2150
AEEQISLESV AMDSPVNMKF NLSGLGSKEH ILELVPAIEP LNNHIRYVIS
2160 2170 2180 2190 2200
QGNEDGVFRI HQRNGLSYLH TAKKKLAPGT YTLEITSIPL YGKKELRKLE
2210 2220
EHNEDDYLLG VLGEALRMRL QIQLY
Length:2,225
Mass (Da):241,552
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1C378F8025BB04C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK220196 mRNA Translation: BAD90381.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220196 mRNA Translation: BAD90381.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ571J3

Organism-specific databases

MGIiMGI:95490 Fbn2

Phylogenomic databases

eggNOGiENOG410IR7H Eukaryota
ENOG410XSTY LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fbn2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di3.90.290.10, 7 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 35 hits
PF00683 TB, 7 hits
SMARTiView protein in SMART
SM00181 EGF, 37 hits
SM00179 EGF_CA, 37 hits
SUPFAMiSSF57184 SSF57184, 9 hits
SSF57581 SSF57581, 7 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 37 hits
PS01186 EGF_2, 21 hits
PS50026 EGF_3, 37 hits
PS01187 EGF_CA, 13 hits
PS51364 TB, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ571J3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q571J3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: December 11, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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