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Entry version 137 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Cholera enterotoxin B-subunit

Gene

ctxB

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei24FucoseCombined sources1
Binding sitei37FucoseCombined sources1
Binding sitei66N-acetyl-D-glucosamine; via carbonyl oxygenCombined sources1
Binding sitei68Fucose; via amide nitrogen and carbonyl oxygenCombined sources1
Binding sitei72GalactoseCombined sources1
Binding sitei77Galactose; via carbonyl oxygenCombined sources1
Binding sitei82GalactoseCombined sources1
Binding sitei111N-acetyl-D-glucosamineCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cholera enterotoxin B-subunitImported
Submitted name:
Cholera enterotoxin subunit BImported
Submitted name:
Cholera toxin B protein (CTB)Imported
Submitted name:
Cholera toxin B subunitImported
Submitted name:
Cholera toxin beta subunitImported
Submitted name:
Cholera toxin subunit BImported
Submitted name:
Cholerae toxin B subunitImported
Submitted name:
CtxBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ctxBImported
ORF Names:C9J66_18955Imported, ERS013165_03981Imported, ERS013202_03762Imported, ERS013206_03003Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio choleraeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri666 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248087 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000043247 Componenti: Unassembled WGS sequence
  • UP000040416 Componenti: Unassembled WGS sequence
  • UP000044806 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03077, 3-Amino-4-{3-[2-(2-Propoxy-Ethoxy)-Ethoxy]-Propylamino}-Cyclobut-3-Ene-1,2-Dione

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501458667922 – 124Sequence analysisAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 107Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei107Cysteine sulfenic acid (-SOH)Combined sources1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 39Galactose bindingCombined sources5
Regioni109 – 115Galactose bindingCombined sources7
Regioni113 – 115Fucose bindingCombined sources3

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008992, Enterotoxin
IPR001835, Enterotoxin_B

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01376, Enterotoxin_b, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00772, ENTEROTOXINB

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50203, SSF50203, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q57193-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKLKFGVFF TVLLSSAYAH GTPQNITDLC AEYHNTQIHT LNDKIFSYTE
60 70 80 90 100
SLAGKREMAI ITFKNGATFQ VEVPGSQHID SQKKAIERMK DTLRIAYLTE
110 120
AKVEKLCVWN NKTPHAIAAI SMAN
Length:124
Mass (Da):13,919
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6BF83FFF7924EA3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25679 mRNA Translation: AAC34728.1
EF158842 Genomic DNA Translation: ABM47299.1
EF591295 Genomic DNA Translation: ABQ65166.1
EU854477 Genomic DNA Translation: ACF75935.1
EU837141 Genomic DNA Translation: ACH71277.1
HM345946 Genomic DNA Translation: ADK25059.1
HM366176 Genomic DNA Translation: ADK26572.1
HM366177 Genomic DNA Translation: ADK26573.1
HM366178 Genomic DNA Translation: ADK26574.1
HM366179 Genomic DNA Translation: ADK26575.1
GQ892076 Genomic DNA Translation: ADN94460.1
GQ892078 Genomic DNA Translation: ADN94462.1
HQ699885 Genomic DNA Translation: AEB78299.1
HQ699886 Genomic DNA Translation: AEB78300.1
HQ699887 Genomic DNA Translation: AEB78301.1
HQ699888 Genomic DNA Translation: AEB78302.1
HQ699889 Genomic DNA Translation: AEB78303.1
HQ699890 Genomic DNA Translation: AEB78304.1
HQ699891 Genomic DNA Translation: AEB78305.1
JN132472 Genomic DNA Translation: AET14210.1
JQ683131 Genomic DNA Translation: AFP32898.1
JQ683132 Genomic DNA Translation: AFP32899.1
JQ683133 Genomic DNA Translation: AFP32900.1
JQ683134 Genomic DNA Translation: AFP32901.1
JQ683135 Genomic DNA Translation: AFP32902.1
JQ683136 Genomic DNA Translation: AFP32903.1
KF498649 Genomic DNA Translation: AHA62823.1
KF498650 Genomic DNA Translation: AHA62824.1
KJ540257 Genomic DNA Translation: AHZ46551.1
KJ540260 Genomic DNA Translation: AHZ46596.1
KJ540261 Genomic DNA Translation: AHZ46610.1
KJ540262 Genomic DNA Translation: AHZ46624.1
KJ540263 Genomic DNA Translation: AHZ46638.1
KJ730029 Genomic DNA Translation: AIE88402.1
KJ730039 Genomic DNA Translation: AIE88412.1
KJ730040 Genomic DNA Translation: AIE88413.1
KJ730041 Genomic DNA Translation: AIE88414.1
KM347971 Genomic DNA Translation: AIW62175.1
KM401563 Genomic DNA Translation: AJT46624.1
KP165408 Genomic DNA Translation: AJW82065.1
KP165409 Genomic DNA Translation: AJW82066.1
KT278766 Genomic DNA Translation: ALL27059.1
KT278767 Genomic DNA Translation: ALL27060.1
KT278768 Genomic DNA Translation: ALL27061.1
KT278769 Genomic DNA Translation: ALL27062.1
KT278770 Genomic DNA Translation: ALL27063.1
KT278771 Genomic DNA Translation: ALL27064.1
KT278772 Genomic DNA Translation: ALL27065.1
KT278773 Genomic DNA Translation: ALL27066.1
X58785 Genomic DNA Translation: CAA41591.1
CWOW01000104 Genomic DNA Translation: CSB24533.1
CWQG01000038 Genomic DNA Translation: CSC69667.1
CWQD01000020 Genomic DNA Translation: CSC91257.1
PYRF01000054 Genomic DNA Translation: PYC77370.1

NCBI Reference Sequences

More...
RefSeqi
WP_000593519.1, NZ_WYCM01000061.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AKO74997; AKO74997; EN12_07055
PYC77370; PYC77370; C9J66_18955

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|666.1977.peg.3751

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25679 mRNA Translation: AAC34728.1
EF158842 Genomic DNA Translation: ABM47299.1
EF591295 Genomic DNA Translation: ABQ65166.1
EU854477 Genomic DNA Translation: ACF75935.1
EU837141 Genomic DNA Translation: ACH71277.1
HM345946 Genomic DNA Translation: ADK25059.1
HM366176 Genomic DNA Translation: ADK26572.1
HM366177 Genomic DNA Translation: ADK26573.1
HM366178 Genomic DNA Translation: ADK26574.1
HM366179 Genomic DNA Translation: ADK26575.1
GQ892076 Genomic DNA Translation: ADN94460.1
GQ892078 Genomic DNA Translation: ADN94462.1
HQ699885 Genomic DNA Translation: AEB78299.1
HQ699886 Genomic DNA Translation: AEB78300.1
HQ699887 Genomic DNA Translation: AEB78301.1
HQ699888 Genomic DNA Translation: AEB78302.1
HQ699889 Genomic DNA Translation: AEB78303.1
HQ699890 Genomic DNA Translation: AEB78304.1
HQ699891 Genomic DNA Translation: AEB78305.1
JN132472 Genomic DNA Translation: AET14210.1
JQ683131 Genomic DNA Translation: AFP32898.1
JQ683132 Genomic DNA Translation: AFP32899.1
JQ683133 Genomic DNA Translation: AFP32900.1
JQ683134 Genomic DNA Translation: AFP32901.1
JQ683135 Genomic DNA Translation: AFP32902.1
JQ683136 Genomic DNA Translation: AFP32903.1
KF498649 Genomic DNA Translation: AHA62823.1
KF498650 Genomic DNA Translation: AHA62824.1
KJ540257 Genomic DNA Translation: AHZ46551.1
KJ540260 Genomic DNA Translation: AHZ46596.1
KJ540261 Genomic DNA Translation: AHZ46610.1
KJ540262 Genomic DNA Translation: AHZ46624.1
KJ540263 Genomic DNA Translation: AHZ46638.1
KJ730029 Genomic DNA Translation: AIE88402.1
KJ730039 Genomic DNA Translation: AIE88412.1
KJ730040 Genomic DNA Translation: AIE88413.1
KJ730041 Genomic DNA Translation: AIE88414.1
KM347971 Genomic DNA Translation: AIW62175.1
KM401563 Genomic DNA Translation: AJT46624.1
KP165408 Genomic DNA Translation: AJW82065.1
KP165409 Genomic DNA Translation: AJW82066.1
KT278766 Genomic DNA Translation: ALL27059.1
KT278767 Genomic DNA Translation: ALL27060.1
KT278768 Genomic DNA Translation: ALL27061.1
KT278769 Genomic DNA Translation: ALL27062.1
KT278770 Genomic DNA Translation: ALL27063.1
KT278771 Genomic DNA Translation: ALL27064.1
KT278772 Genomic DNA Translation: ALL27065.1
KT278773 Genomic DNA Translation: ALL27066.1
X58785 Genomic DNA Translation: CAA41591.1
CWOW01000104 Genomic DNA Translation: CSB24533.1
CWQG01000038 Genomic DNA Translation: CSC69667.1
CWQD01000020 Genomic DNA Translation: CSC91257.1
PYRF01000054 Genomic DNA Translation: PYC77370.1
RefSeqiWP_000593519.1, NZ_WYCM01000061.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EEIX-ray2.00D/E/F/G/H22-124[»]
1LLRX-ray1.46D/E/F/G/H22-124[»]
1PZJX-ray1.46D/E/F/G/H22-124[»]
1PZKX-ray1.35D/E/F/G/H22-124[»]
5ELBX-ray1.08A/B/C/D/E/F/G/H/I/J22-124[»]
5LZHX-ray1.13A/B/C/D/E22-124[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Chemistry databases

DrugBankiDB03077, 3-Amino-4-{3-[2-(2-Propoxy-Ethoxy)-Ethoxy]-Propylamino}-Cyclobut-3-Ene-1,2-Dione

Genome annotation databases

EnsemblBacteriaiAKO74997; AKO74997; EN12_07055
PYC77370; PYC77370; C9J66_18955
PATRICifig|666.1977.peg.3751

Family and domain databases

InterProiView protein in InterPro
IPR008992, Enterotoxin
IPR001835, Enterotoxin_B
PfamiView protein in Pfam
PF01376, Enterotoxin_b, 1 hit
PRINTSiPR00772, ENTEROTOXINB
SUPFAMiSSF50203, SSF50203, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ57193_VIBCL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q57193
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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