UniProtKB - Q570Y9 (DPTOR_MOUSE)
DEP domain-containing mTOR-interacting protein
Deptor
Functioni
GO - Biological processi
- intracellular signal transduction Source: InterPro
- negative regulation of cell size Source: MGI
- negative regulation of protein kinase activity Source: MGI
- negative regulation of TOR signaling Source: MGI
- regulation of extrinsic apoptotic signaling pathway Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: DEP domain-containing mTOR-interacting proteinAlternative name(s): DEP domain-containing protein 6 |
Gene namesi | Name:Deptor Synonyms:Depdc6, Kiaa4200 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2146322, Deptor |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284785 | 1 – 409 | DEP domain-containing mTOR-interacting proteinAdd BLAST | 409 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 241 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 244 | PhosphoserineCombined sources | 1 | |
Modified residuei | 258 | PhosphoserineBy similarity | 1 | |
Modified residuei | 259 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 263 | PhosphoserineBy similarity | 1 | |
Modified residuei | 265 | PhosphoserineCombined sources | 1 | |
Modified residuei | 280 | PhosphoserineCombined sources | 1 | |
Modified residuei | 282 | PhosphoserineBy similarity | 1 | |
Modified residuei | 283 | PhosphoserineBy similarity | 1 | |
Modified residuei | 287 | PhosphoserineBy similarity | 1 | |
Modified residuei | 293 | PhosphoserineCombined sources | 1 | |
Modified residuei | 297 | PhosphoserineBy similarity | 1 | |
Modified residuei | 298 | PhosphoserineBy similarity | 1 | |
Modified residuei | 299 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q570Y9 |
PRIDEi | Q570Y9 |
PTM databases
iPTMneti | Q570Y9 |
PhosphoSitePlusi | Q570Y9 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000022419, Expressed in brown adipose tissue and 271 other tissues |
ExpressionAtlasi | Q570Y9, baseline and differential |
Genevisiblei | Q570Y9, MM |
Interactioni
Subunit structurei
Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR.
Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2 (By similarity).
Interacts (via PDZ domain) with MINAR1 (via N-terminus) (By similarity).
Interacts with SIK3 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 220946, 1 interactor |
STRINGi | 10090.ENSMUSP00000094167 |
Miscellaneous databases
RNActi | Q570Y9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 119 | DEP 1PROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 146 – 219 | DEP 2PROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 330 – 407 | PDZPROSITE-ProRule annotationAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 235 – 299 | Ser-richAdd BLAST | 65 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QS4Y, Eukaryota |
GeneTreei | ENSGT00520000055667 |
HOGENOMi | CLU_042535_0_0_1 |
InParanoidi | Q570Y9 |
OMAi | DTHDSPF |
PhylomeDBi | Q570Y9 |
Family and domain databases
CDDi | cd04442, DEP_1_DEP6, 1 hit cd04441, DEP_2_DEP6, 1 hit |
Gene3Di | 1.10.10.10, 2 hits 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR037589, DEPTOR IPR037335, DEPTOR_DEP_1 IPR037336, DEPTOR_DEP_2 IPR001478, PDZ IPR036034, PDZ_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR22829:SF18, PTHR22829:SF18, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 2 hits |
SMARTi | View protein in SMART SM00049, DEP, 2 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 2 hits SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 2 hits PS50106, PDZ, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEGSSGGSG SSDSNAGGSG GVQQRELERM AEVLVTGEQL RLRLHEEKVI
60 70 80 90 100
KDRRHHLKTY PNCFVAKELI DWLIEHKEAS DRETAIKLMQ KLADRGIIHH
110 120 130 140 150
VCDEHKEFKD VKLFYRFRKD DGTFALDSEV KAFMRGQRLY EKLMSPETTL
160 170 180 190 200
LQPREEEGVK YERTFMASEF LDWLVQEGEA TTRKEAEQLC HRLMDHGIIQ
210 220 230 240 250
HVSNKHPFVD SNLLYQFRMN FRRRRRLMEL LNETSPSSQE THDSPFCLRK
260 270 280 290 300
QSHDSRKSTS FMSVSPSKEI KIVSAVRRSS MSSCGSSGYF SSSPTLSSSP
310 320 330 340 350
PVLCNPKSVL KRPVTSEELL TPGAPYARKT FTIVGDAVGW GFVVRGSKPC
360 370 380 390 400
HIQAVDPSGP AAAAGMKVCQ FVVSVNGLNV LNVDYRTVSN LILTGPRTIV
MEVMEELDC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB2ZRS5 | B2ZRS5_MOUSE | DEP domain-containing mTOR-interact... | Deptor Depdc6 | 401 | Annotation score: | ||
A0A2I3BRE1 | A0A2I3BRE1_MOUSE | DEP domain-containing mTOR-interact... | Deptor | 100 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | S → G in BAE26298 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 125 | A → P in BAE26298 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 128 | S → N in BAE26298 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 149 | T → I in BAE26298 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024648 | 1 – 40 | MEEGS…TGEQL → MKQAFLVVLRHSISEDRLPP LSVITSGC in isoform 2. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_024649 | 368 – 409 | VCQFV…EELDC → DTGTESRKIVTSRLAWATWQ DLMGGKVGGDAIPI in isoform 3. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK220300 mRNA Translation: BAD90225.1 Different initiation. AK139888 mRNA Translation: BAE24172.1 AK145208 mRNA Translation: BAE26298.1 |
CCDSi | CCDS27474.1 [Q570Y9-1] CCDS27475.1 [Q570Y9-2] |
RefSeqi | NP_001033026.1, NM_001037937.3 [Q570Y9-2] NP_663445.2, NM_145470.3 [Q570Y9-1] |
Genome annotation databases
Ensembli | ENSMUST00000023056; ENSMUSP00000023056; ENSMUSG00000022419 [Q570Y9-2] ENSMUST00000096433; ENSMUSP00000094167; ENSMUSG00000022419 [Q570Y9-1] |
GeneIDi | 97998 |
KEGGi | mmu:97998 |
UCSCi | uc007vsb.2, mouse [Q570Y9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK220300 mRNA Translation: BAD90225.1 Different initiation. AK139888 mRNA Translation: BAE24172.1 AK145208 mRNA Translation: BAE26298.1 |
CCDSi | CCDS27474.1 [Q570Y9-1] CCDS27475.1 [Q570Y9-2] |
RefSeqi | NP_001033026.1, NM_001037937.3 [Q570Y9-2] NP_663445.2, NM_145470.3 [Q570Y9-1] |
3D structure databases
SMRi | Q570Y9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 220946, 1 interactor |
STRINGi | 10090.ENSMUSP00000094167 |
PTM databases
iPTMneti | Q570Y9 |
PhosphoSitePlusi | Q570Y9 |
Proteomic databases
PaxDbi | Q570Y9 |
PRIDEi | Q570Y9 |
Protocols and materials databases
Antibodypediai | 13704, 272 antibodies |
DNASUi | 97998 |
Genome annotation databases
Ensembli | ENSMUST00000023056; ENSMUSP00000023056; ENSMUSG00000022419 [Q570Y9-2] ENSMUST00000096433; ENSMUSP00000094167; ENSMUSG00000022419 [Q570Y9-1] |
GeneIDi | 97998 |
KEGGi | mmu:97998 |
UCSCi | uc007vsb.2, mouse [Q570Y9-1] |
Organism-specific databases
CTDi | 64798 |
MGIi | MGI:2146322, Deptor |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS4Y, Eukaryota |
GeneTreei | ENSGT00520000055667 |
HOGENOMi | CLU_042535_0_0_1 |
InParanoidi | Q570Y9 |
OMAi | DTHDSPF |
PhylomeDBi | Q570Y9 |
Miscellaneous databases
BioGRID-ORCSi | 97998, 0 hits in 18 CRISPR screens |
ChiTaRSi | Deptor, mouse |
PROi | PR:Q570Y9 |
RNActi | Q570Y9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022419, Expressed in brown adipose tissue and 271 other tissues |
ExpressionAtlasi | Q570Y9, baseline and differential |
Genevisiblei | Q570Y9, MM |
Family and domain databases
CDDi | cd04442, DEP_1_DEP6, 1 hit cd04441, DEP_2_DEP6, 1 hit |
Gene3Di | 1.10.10.10, 2 hits 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR037589, DEPTOR IPR037335, DEPTOR_DEP_1 IPR037336, DEPTOR_DEP_2 IPR001478, PDZ IPR036034, PDZ_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR22829:SF18, PTHR22829:SF18, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 2 hits |
SMARTi | View protein in SMART SM00049, DEP, 2 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 2 hits SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 2 hits PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DPTOR_MOUSE | |
Accessioni | Q570Y9Primary (citable) accession number: Q570Y9 Secondary accession number(s): Q3UM00, Q3UT08 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | April 17, 2007 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot