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Protein

OCIA domain-containing protein 2

Gene

OCIAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
OCIA domain-containing protein 2
Alternative name(s):
Ovarian carcinoma immunoreactive antigen-like protein
Gene namesi
Name:OCIAD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145247.11
HGNCiHGNC:28685 OCIAD2
neXtProtiNX_Q56VL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi132299
OpenTargetsiENSG00000145247
PharmGKBiPA128394755

Polymorphism and mutation databases

DMDMi74741044

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993921 – 154OCIA domain-containing protein 2Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ56VL3
MaxQBiQ56VL3
PaxDbiQ56VL3
PeptideAtlasiQ56VL3
PRIDEiQ56VL3
ProteomicsDBi62591
62592 [Q56VL3-2]

PTM databases

iPTMnetiQ56VL3
PhosphoSitePlusiQ56VL3
SwissPalmiQ56VL3

Expressioni

Gene expression databases

BgeeiENSG00000145247 Expressed in 195 organ(s), highest expression level in kidney epithelium
CleanExiHS_OCIAD2
ExpressionAtlasiQ56VL3 baseline and differential
GenevisibleiQ56VL3 HS

Organism-specific databases

HPAiHPA040979
HPA041090

Interactioni

Protein-protein interaction databases

BioGridi126317, 5 interactors
IntActiQ56VL3, 3 interactors
STRINGi9606.ENSP00000423014

Structurei

3D structure databases

ProteinModelPortaliQ56VL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 120OCIAAdd BLAST120

Phylogenomic databases

eggNOGiENOG410J13G Eukaryota
ENOG4111YF8 LUCA
GeneTreeiENSGT00530000063690
HOVERGENiHBG054610
InParanoidiQ56VL3
OMAiVSTHGNQ
OrthoDBiEOG091G0USR
PhylomeDBiQ56VL3
TreeFamiTF327106

Family and domain databases

InterProiView protein in InterPro
IPR009764 OCIA
PfamiView protein in Pfam
PF07051 OCIA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q56VL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASASARGNQ DKDAHFPPPS KQSLLFCPKS KLHIHRAEIS KIMRECQEES
60 70 80 90 100
FWKRALPFSL VSMLVTQGLV YQGYLAANSR FGSLPKVALA GLLGFGLGKV
110 120 130 140 150
SYIGVCQSKF HFFEDQLRGA GFGPQHNRHC LLTCEECKIK HGLSEKGDSQ

PSAS
Length:154
Mass (Da):16,954
Last modified:May 10, 2005 - v1
Checksum:iB2278F751BA03A3E
GO
Isoform 2 (identifier: Q56VL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-154: LAGLLGFGLG...EKGDSQPSAS → RTASLPVRNAK

Show »
Length:99
Mass (Da):11,030
Checksum:i7DC87F06B4F35084
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD77D6RD77_HUMAN
OCIA domain-containing protein 2
OCIAD2
61Annotation score:
J3KPI9J3KPI9_HUMAN
OCIA domain-containing protein 2
OCIAD2
88Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05395044R → Q. Corresponds to variant dbSNP:rs7676916Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02762689 – 154LAGLL…QPSAS → RTASLPVRNAK in isoform 2. 2 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY472117 mRNA Translation: AAS47684.1
AK298305 mRNA Translation: BAG60559.1
CR749310 mRNA Translation: CAH18165.1
CH471069 Genomic DNA Translation: EAW93077.1
CH471069 Genomic DNA Translation: EAW93075.1
BC032808 mRNA Translation: AAH32808.1
CCDSiCCDS33981.1 [Q56VL3-1]
CCDS3485.1 [Q56VL3-2]
RefSeqiNP_001014446.1, NM_001014446.2 [Q56VL3-1]
NP_001273702.1, NM_001286773.1 [Q56VL3-2]
NP_689611.1, NM_152398.3 [Q56VL3-2]
UniGeneiHs.95835

Genome annotation databases

EnsembliENST00000273860; ENSP00000273860; ENSG00000145247 [Q56VL3-2]
ENST00000508632; ENSP00000423014; ENSG00000145247 [Q56VL3-1]
ENST00000620187; ENSP00000483997; ENSG00000145247 [Q56VL3-2]
GeneIDi132299
KEGGihsa:132299
UCSCiuc003gyt.5 human [Q56VL3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOCAD2_HUMAN
AccessioniPrimary (citable) accession number: Q56VL3
Secondary accession number(s): B4DPE7, Q8N544
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 10, 2005
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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