UniProtKB - Q56UN5 (M3K19_HUMAN)
Protein
Mitogen-activated protein kinase kinase kinase 19
Gene
MAP3K19
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1089 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 1186 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1067 – 1075 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q56UN5 |
SignaLinki | Q56UN5 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinase kinase kinase 19 (EC:2.7.11.1)Alternative name(s): Regulated in COPD, protein kinase SPS1/STE20-related protein kinase YSK4 |
Gene namesi | Name:MAP3K19 Synonyms:RCK, YSK4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000176601.11 |
HGNCi | HGNC:26249, MAP3K19 |
neXtProti | NX_Q56UN5 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 80122 |
OpenTargetsi | ENSG00000176601 |
PharmGKBi | PA142670554 |
Miscellaneous databases
Pharosi | Q56UN5, Tchem |
Chemistry databases
ChEMBLi | CHEMBL6191 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q56UN5 |
Polymorphism and mutation databases
BioMutai | MAP3K19 |
DMDMi | 74755104 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232640 | 1 – 1328 | Mitogen-activated protein kinase kinase kinase 19Add BLAST | 1328 |
Proteomic databases
jPOSTi | Q56UN5 |
MaxQBi | Q56UN5 |
PaxDbi | Q56UN5 |
PeptideAtlasi | Q56UN5 |
PRIDEi | Q56UN5 |
ProteomicsDBi | 62584 [Q56UN5-1] 62586 [Q56UN5-3] 62587 [Q56UN5-4] 62588 [Q56UN5-5] 7260 |
PTM databases
iPTMneti | Q56UN5 |
PhosphoSitePlusi | Q56UN5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176601, Expressed in bronchial epithelial cell and 118 other tissues |
ExpressionAtlasi | Q56UN5, baseline and differential |
Genevisiblei | Q56UN5, HS |
Organism-specific databases
HPAi | ENSG00000176601, Tissue enhanced (brain, fallopian tube) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123124, 1 interactor |
IntActi | Q56UN5, 1 interactor |
MINTi | Q56UN5 |
STRINGi | 9606.ENSP00000365005 |
Chemistry databases
BindingDBi | Q56UN5 |
Miscellaneous databases
RNActi | Q56UN5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1061 – 1324 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 264 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0198, Eukaryota |
GeneTreei | ENSGT00940000160383 |
HOGENOMi | CLU_599846_0_0_1 |
InParanoidi | Q56UN5 |
OMAi | RMPQIEK |
OrthoDBi | 55144at2759 |
PhylomeDBi | Q56UN5 |
TreeFami | TF332735 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q56UN5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ
60 70 80 90 100
DGDCSHSTLV NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED
110 120 130 140 150
LKEKNLINSS LQEWAQAHAV SHPNEIETVE LRKKKLTMRP LVLQKEESSR
160 170 180 190 200
ELCNVNLGFL LPRSCLELNI SKSVTREDAP HFLKEQQRKS EEFSTSHMKY
210 220 230 240 250
SGRSIKFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS LTSFVPKLSV
260 270 280 290 300
SVRQSDELSP SNEPPGALVK SLMDPTLRSS DGFIWSRNMC SFPKTNHHRQ
310 320 330 340 350
CLEKEENWKS KEIEECNKIE ITHFEKGQSL VSFENLKEGN IPAVREEDID
360 370 380 390 400
CHGSKTRKPE EENSQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS
410 420 430 440 450
EITPSQDEEM RNNKAASKRV SLHKNEAMEP NNILEECTVL KSLSSVVFDD
460 470 480 490 500
PIDKLPEGCS SMETNIKISI AERAKPEMSR MVPLIHITFP VDGSPKEPVI
510 520 530 540 550
AKPSLQTRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS KTKTSKKTPQ
560 570 580 590 600
NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK
610 620 630 640 650
QSTHRTQKPK KQSFPCICKN PGTQKSCVPL SVQPTEPRLN YLDLKYSDMF
660 670 680 690 700
KEINSTANGP GIYEMFGTPV YCHVRETERD ENTYYREICS APSGRRITNK
710 720 730 740 750
CRSSHSERKS NIRTRLSQKK THMKCPKTSF GIKQEHKVLI SKEKSSKAVH
760 770 780 790 800
SNLHDIENGD GISEPDWQIK SSGNEFLSSK DEIHPMNLAQ TPEQSMKQNE
810 820 830 840 850
FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL EELHHQIPFI
860 870 880 890 900
PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS
910 920 930 940 950
KTLTNFSFQA KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN
960 970 980 990 1000
SISQEIMDSV NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL
1010 1020 1030 1040 1050
NLVLRWRGST PKEMGRETTK VKIQRHSSGL RIYDREEKFL ISNEKKIFSE
1060 1070 1080 1090 1100
NSLKSEEPIL WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSNKLA
1110 1120 1130 1140 1150
AEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM EFVPGGSISS
1160 1170 1180 1190 1200
IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII
1210 1220 1230 1240 1250
KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI
1260 1270 1280 1290 1300
WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF
1310 1320
VRMCLTRDQH ERPSALQLLK HSFLERSH
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C041 | H7C041_HUMAN | Mitogen-activated protein kinase ki... | MAP3K19 | 697 | Annotation score: | ||
A0A1B0GTF4 | A0A1B0GTF4_HUMAN | Mitogen-activated protein kinase ki... | MAP3K19 | 910 | Annotation score: | ||
A0A590UJK1 | A0A590UJK1_HUMAN | Mitogen-activated protein kinase ki... | MAP3K19 | 212 | Annotation score: | ||
A0A590UJV9 | A0A590UJV9_HUMAN | Mitogen-activated protein kinase ki... | MAP3K19 | 157 | Annotation score: | ||
C9JGQ2 | C9JGQ2_HUMAN | Mitogen-activated protein kinase ki... | MAP3K19 | 21 | Annotation score: |
Sequence cautioni
The sequence BAB15538 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1073 – 1074 | GT → RE in AAH34417 (PubMed:15489334).Curated | 2 | |
Sequence conflicti | 1235 | A → V in BAB15538 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051687 | 438 | T → I. Corresponds to variant dbSNP:rs16831235Ensembl. | 1 | |
Natural variantiVAR_041334 | 500 | I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_051688 | 676 | E → Q. Corresponds to variant dbSNP:rs1112542Ensembl. | 1 | |
Natural variantiVAR_051689 | 812 | E → G. Corresponds to variant dbSNP:rs3905317Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017924 | 79 – 191 | Missing in isoform 3. 1 PublicationAdd BLAST | 113 | |
Alternative sequenceiVSP_055367 | 207 – 1074 | Missing in isoform 7. 1 PublicationAdd BLAST | 868 | |
Alternative sequenceiVSP_017925 | 207 – 1024 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 818 | |
Alternative sequenceiVSP_017926 | 1064 – 1111 | Missing in isoform 4. 1 PublicationAdd BLAST | 48 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000358371; ENSP00000351140; ENSG00000176601 [Q56UN5-3] ENST00000375844; ENSP00000365004; ENSG00000176601 [Q56UN5-5] ENST00000375845; ENSP00000365005; ENSG00000176601 [Q56UN5-1] ENST00000392915; ENSP00000376647; ENSG00000176601 [Q56UN5-1] ENST00000392917; ENSP00000376649; ENSG00000176601 [Q56UN5-7] ENST00000392918; ENSP00000376650; ENSG00000176601 [Q56UN5-4] |
GeneIDi | 80122 |
KEGGi | hsa:80122 |
UCSCi | uc002tue.2, human [Q56UN5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q56UN5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123124, 1 interactor |
IntActi | Q56UN5, 1 interactor |
MINTi | Q56UN5 |
STRINGi | 9606.ENSP00000365005 |
Chemistry databases
BindingDBi | Q56UN5 |
ChEMBLi | CHEMBL6191 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q56UN5 |
PTM databases
iPTMneti | Q56UN5 |
PhosphoSitePlusi | Q56UN5 |
Polymorphism and mutation databases
BioMutai | MAP3K19 |
DMDMi | 74755104 |
Proteomic databases
jPOSTi | Q56UN5 |
MaxQBi | Q56UN5 |
PaxDbi | Q56UN5 |
PeptideAtlasi | Q56UN5 |
PRIDEi | Q56UN5 |
ProteomicsDBi | 62584 [Q56UN5-1] 62586 [Q56UN5-3] 62587 [Q56UN5-4] 62588 [Q56UN5-5] 7260 |
Protocols and materials databases
Antibodypediai | 2102, 49 antibodies |
Genome annotation databases
Ensembli | ENST00000358371; ENSP00000351140; ENSG00000176601 [Q56UN5-3] ENST00000375844; ENSP00000365004; ENSG00000176601 [Q56UN5-5] ENST00000375845; ENSP00000365005; ENSG00000176601 [Q56UN5-1] ENST00000392915; ENSP00000376647; ENSG00000176601 [Q56UN5-1] ENST00000392917; ENSP00000376649; ENSG00000176601 [Q56UN5-7] ENST00000392918; ENSP00000376650; ENSG00000176601 [Q56UN5-4] |
GeneIDi | 80122 |
KEGGi | hsa:80122 |
UCSCi | uc002tue.2, human [Q56UN5-1] |
Organism-specific databases
CTDi | 80122 |
DisGeNETi | 80122 |
EuPathDBi | HostDB:ENSG00000176601.11 |
GeneCardsi | MAP3K19 |
HGNCi | HGNC:26249, MAP3K19 |
HPAi | ENSG00000176601, Tissue enhanced (brain, fallopian tube) |
neXtProti | NX_Q56UN5 |
OpenTargetsi | ENSG00000176601 |
PharmGKBi | PA142670554 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0198, Eukaryota |
GeneTreei | ENSGT00940000160383 |
HOGENOMi | CLU_599846_0_0_1 |
InParanoidi | Q56UN5 |
OMAi | RMPQIEK |
OrthoDBi | 55144at2759 |
PhylomeDBi | Q56UN5 |
TreeFami | TF332735 |
Enzyme and pathway databases
PathwayCommonsi | Q56UN5 |
SignaLinki | Q56UN5 |
Miscellaneous databases
BioGRID-ORCSi | 80122, 6 hits in 847 CRISPR screens |
ChiTaRSi | MAP3K19, human |
GenomeRNAii | 80122 |
Pharosi | Q56UN5, Tchem |
PROi | PR:Q56UN5 |
RNActi | Q56UN5, protein |
Gene expression databases
Bgeei | ENSG00000176601, Expressed in bronchial epithelial cell and 118 other tissues |
ExpressionAtlasi | Q56UN5, baseline and differential |
Genevisiblei | Q56UN5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M3K19_HUMAN | |
Accessioni | Q56UN5Primary (citable) accession number: Q56UN5 Secondary accession number(s): B2RP57 Q9H5T2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index