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Protein

Mitogen-activated protein kinase kinase kinase 19

Gene

MAP3K19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1089ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1067 – 1075ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q56UN5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 19 (EC:2.7.11.1)
Alternative name(s):
Regulated in COPD, protein kinase
SPS1/STE20-related protein kinase YSK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP3K19
Synonyms:RCK, YSK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176601.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26249 MAP3K19

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q56UN5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80122

Open Targets

More...
OpenTargetsi
ENSG00000176601

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670554

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6191

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAP3K19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74755104

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002326401 – 1328Mitogen-activated protein kinase kinase kinase 19Add BLAST1328

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q56UN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q56UN5

PeptideAtlas

More...
PeptideAtlasi
Q56UN5

PRoteomics IDEntifications database

More...
PRIDEi
Q56UN5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62584
62585 [Q56UN5-2]
62586 [Q56UN5-3]
62587 [Q56UN5-4]
62588 [Q56UN5-5]
62589 [Q56UN5-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q56UN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q56UN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176601 Expressed in 91 organ(s), highest expression level in bronchial epithelial cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_YSK4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q56UN5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q56UN5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011388

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123124, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365005

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q56UN5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q56UN5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q56UN5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1061 – 1324Protein kinasePROSITE-ProRule annotationAdd BLAST264

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0198 Eukaryota
ENOG410XQGS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160383

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094170

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q56UN5

KEGG Orthology (KO)

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KOi
K17533

Identification of Orthologs from Complete Genome Data

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OMAi
RHENKYY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0AR6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q56UN5

TreeFam database of animal gene trees

More...
TreeFami
TF332735

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q56UN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ
60 70 80 90 100
DGDCSHSTLV NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED
110 120 130 140 150
LKEKNLINSS LQEWAQAHAV SHPNEIETVE LRKKKLTMRP LVLQKEESSR
160 170 180 190 200
ELCNVNLGFL LPRSCLELNI SKSVTREDAP HFLKEQQRKS EEFSTSHMKY
210 220 230 240 250
SGRSIKFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS LTSFVPKLSV
260 270 280 290 300
SVRQSDELSP SNEPPGALVK SLMDPTLRSS DGFIWSRNMC SFPKTNHHRQ
310 320 330 340 350
CLEKEENWKS KEIEECNKIE ITHFEKGQSL VSFENLKEGN IPAVREEDID
360 370 380 390 400
CHGSKTRKPE EENSQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS
410 420 430 440 450
EITPSQDEEM RNNKAASKRV SLHKNEAMEP NNILEECTVL KSLSSVVFDD
460 470 480 490 500
PIDKLPEGCS SMETNIKISI AERAKPEMSR MVPLIHITFP VDGSPKEPVI
510 520 530 540 550
AKPSLQTRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS KTKTSKKTPQ
560 570 580 590 600
NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK
610 620 630 640 650
QSTHRTQKPK KQSFPCICKN PGTQKSCVPL SVQPTEPRLN YLDLKYSDMF
660 670 680 690 700
KEINSTANGP GIYEMFGTPV YCHVRETERD ENTYYREICS APSGRRITNK
710 720 730 740 750
CRSSHSERKS NIRTRLSQKK THMKCPKTSF GIKQEHKVLI SKEKSSKAVH
760 770 780 790 800
SNLHDIENGD GISEPDWQIK SSGNEFLSSK DEIHPMNLAQ TPEQSMKQNE
810 820 830 840 850
FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL EELHHQIPFI
860 870 880 890 900
PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS
910 920 930 940 950
KTLTNFSFQA KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN
960 970 980 990 1000
SISQEIMDSV NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL
1010 1020 1030 1040 1050
NLVLRWRGST PKEMGRETTK VKIQRHSSGL RIYDREEKFL ISNEKKIFSE
1060 1070 1080 1090 1100
NSLKSEEPIL WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSNKLA
1110 1120 1130 1140 1150
AEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM EFVPGGSISS
1160 1170 1180 1190 1200
IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII
1210 1220 1230 1240 1250
KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI
1260 1270 1280 1290 1300
WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF
1310 1320
VRMCLTRDQH ERPSALQLLK HSFLERSH
Length:1,328
Mass (Da):150,537
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10E225EDB1EF4FA3
GO
Isoform 2 (identifier: Q56UN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1122-1127: NIVAYL → PDQGPA
     1128-1328: Missing.

Show »
Length:1,127
Mass (Da):127,941
Checksum:iB031EFB739B3B28B
GO
Isoform 3 (identifier: Q56UN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-191: Missing.

Show »
Length:1,215
Mass (Da):137,548
Checksum:iF0197C84572ED393
GO
Isoform 4 (identifier: Q56UN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.
     1064-1111: Missing.

Show »
Length:462
Mass (Da):52,504
Checksum:i123177F7965C4C64
GO
Isoform 5 (identifier: Q56UN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.

Show »
Length:510
Mass (Da):57,659
Checksum:i27E67C237A50AD36
GO
Isoform 6 (identifier: Q56UN5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1139: Missing.
     1308-1328: Missing.

Show »
Length:168
Mass (Da):18,702
Checksum:iA9B594F15FE13CA9
GO
Isoform 7 (identifier: Q56UN5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1074: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):51,920
Checksum:i2B40C5FC91E2D11B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MWG7A8MWG7_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
1,328Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C041H7C041_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
697Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGQ2C9JGQ2_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTF4A0A1B0GTF4_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
910Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1235A → V in BAB15538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051687438T → I. Corresponds to variant dbSNP:rs16831235Ensembl.1
Natural variantiVAR_041334500I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_051688676E → Q. Corresponds to variant dbSNP:rs1112542Ensembl.1
Natural variantiVAR_051689812E → G. Corresponds to variant dbSNP:rs3905317Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0179221 – 1139Missing in isoform 6. 2 PublicationsAdd BLAST1139
Alternative sequenceiVSP_01792479 – 191Missing in isoform 3. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_055367207 – 1074Missing in isoform 7. 1 PublicationAdd BLAST868
Alternative sequenceiVSP_017925207 – 1024Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST818
Alternative sequenceiVSP_0179261064 – 1111Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0179271122 – 1127NIVAYL → PDQGPA in isoform 2. 1 Publication6
Alternative sequenceiVSP_0179281128 – 1328Missing in isoform 2. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_0179231308 – 1328Missing in isoform 6. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY574901 mRNA Translation: AAT81410.1
AY574902 mRNA Translation: AAT81411.1
AY574903 mRNA Translation: AAT81412.1
AY574904 mRNA Translation: AAT81413.1
AY574905 mRNA Translation: AAT81414.1
AK026727 mRNA Translation: BAB15538.1
AC016725 Genomic DNA Translation: AAY14999.1
AC020602 Genomic DNA No translation available.
BC034417 mRNA Translation: AAH34417.1
BC137276 mRNA Translation: AAI37277.1
BC137277 mRNA Translation: AAI37278.1
BC144555 mRNA Translation: AAI44556.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2176.2 [Q56UN5-1]
CCDS33293.1 [Q56UN5-5]
CCDS63020.1 [Q56UN5-3]
CCDS63021.1 [Q56UN5-7]
CCDS63022.1 [Q56UN5-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001018054.1, NM_001018044.2 [Q56UN5-3]
NP_001018056.1, NM_001018046.2 [Q56UN5-5]
NP_001018057.1, NM_001018047.2 [Q56UN5-4]
NP_001269812.1, NM_001282883.1 [Q56UN5-7]
NP_001308106.1, NM_001321177.1
NP_079328.3, NM_025052.4 [Q56UN5-1]
XP_011510194.1, XM_011511892.1 [Q56UN5-1]
XP_016860492.1, XM_017005003.1 [Q56UN5-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.659395

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000358371; ENSP00000351140; ENSG00000176601 [Q56UN5-3]
ENST00000375844; ENSP00000365004; ENSG00000176601 [Q56UN5-5]
ENST00000375845; ENSP00000365005; ENSG00000176601 [Q56UN5-1]
ENST00000392915; ENSP00000376647; ENSG00000176601 [Q56UN5-1]
ENST00000392917; ENSP00000376649; ENSG00000176601 [Q56UN5-7]
ENST00000392918; ENSP00000376650; ENSG00000176601 [Q56UN5-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80122

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80122

UCSC genome browser

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UCSCi
uc002tue.2 human [Q56UN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574901 mRNA Translation: AAT81410.1
AY574902 mRNA Translation: AAT81411.1
AY574903 mRNA Translation: AAT81412.1
AY574904 mRNA Translation: AAT81413.1
AY574905 mRNA Translation: AAT81414.1
AK026727 mRNA Translation: BAB15538.1
AC016725 Genomic DNA Translation: AAY14999.1
AC020602 Genomic DNA No translation available.
BC034417 mRNA Translation: AAH34417.1
BC137276 mRNA Translation: AAI37277.1
BC137277 mRNA Translation: AAI37278.1
BC144555 mRNA Translation: AAI44556.1
CCDSiCCDS2176.2 [Q56UN5-1]
CCDS33293.1 [Q56UN5-5]
CCDS63020.1 [Q56UN5-3]
CCDS63021.1 [Q56UN5-7]
CCDS63022.1 [Q56UN5-4]
RefSeqiNP_001018054.1, NM_001018044.2 [Q56UN5-3]
NP_001018056.1, NM_001018046.2 [Q56UN5-5]
NP_001018057.1, NM_001018047.2 [Q56UN5-4]
NP_001269812.1, NM_001282883.1 [Q56UN5-7]
NP_001308106.1, NM_001321177.1
NP_079328.3, NM_025052.4 [Q56UN5-1]
XP_011510194.1, XM_011511892.1 [Q56UN5-1]
XP_016860492.1, XM_017005003.1 [Q56UN5-1]
UniGeneiHs.659395

3D structure databases

ProteinModelPortaliQ56UN5
SMRiQ56UN5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123124, 1 interactor
STRINGi9606.ENSP00000365005

Chemistry databases

BindingDBiQ56UN5
ChEMBLiCHEMBL6191

PTM databases

iPTMnetiQ56UN5
PhosphoSitePlusiQ56UN5

Polymorphism and mutation databases

BioMutaiMAP3K19
DMDMi74755104

Proteomic databases

MaxQBiQ56UN5
PaxDbiQ56UN5
PeptideAtlasiQ56UN5
PRIDEiQ56UN5
ProteomicsDBi62584
62585 [Q56UN5-2]
62586 [Q56UN5-3]
62587 [Q56UN5-4]
62588 [Q56UN5-5]
62589 [Q56UN5-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358371; ENSP00000351140; ENSG00000176601 [Q56UN5-3]
ENST00000375844; ENSP00000365004; ENSG00000176601 [Q56UN5-5]
ENST00000375845; ENSP00000365005; ENSG00000176601 [Q56UN5-1]
ENST00000392915; ENSP00000376647; ENSG00000176601 [Q56UN5-1]
ENST00000392917; ENSP00000376649; ENSG00000176601 [Q56UN5-7]
ENST00000392918; ENSP00000376650; ENSG00000176601 [Q56UN5-4]
GeneIDi80122
KEGGihsa:80122
UCSCiuc002tue.2 human [Q56UN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80122
DisGeNETi80122
EuPathDBiHostDB:ENSG00000176601.11

GeneCards: human genes, protein and diseases

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GeneCardsi
MAP3K19

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0002473
HGNCiHGNC:26249 MAP3K19
HPAiHPA011388
neXtProtiNX_Q56UN5
OpenTargetsiENSG00000176601
PharmGKBiPA142670554

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0198 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00940000160383
HOVERGENiHBG094170
InParanoidiQ56UN5
KOiK17533
OMAiRHENKYY
OrthoDBiEOG091G0AR6
PhylomeDBiQ56UN5
TreeFamiTF332735

Enzyme and pathway databases

SignaLinkiQ56UN5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAP3K19 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80122

Protein Ontology

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PROi
PR:Q56UN5

Gene expression databases

BgeeiENSG00000176601 Expressed in 91 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_YSK4
ExpressionAtlasiQ56UN5 baseline and differential
GenevisibleiQ56UN5 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3K19_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q56UN5
Secondary accession number(s): B2RP57
, B7ZMH9, E2QRE3, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 10, 2005
Last modified: December 5, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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