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UniProtKB - Q56UN5 (M3K19_HUMAN)

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Protein

Mitogen-activated protein kinase kinase kinase 19

Gene

MAP3K19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1089ATPPROSITE-ProRule annotation1
Active sitei1186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1067 – 1075ATPPROSITE-ProRule annotation9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ56UN5

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 19 (EC:2.7.11.1)
Alternative name(s):
Regulated in COPD, protein kinase
SPS1/STE20-related protein kinase YSK4
Gene namesi
Name:MAP3K19
Synonyms:RCK, YSK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000176601.11
HGNCiHGNC:26249 MAP3K19
neXtProtiNX_Q56UN5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi80122
OpenTargetsiENSG00000176601
PharmGKBiPA142670554

Chemistry databases

ChEMBLiCHEMBL6191
GuidetoPHARMACOLOGYi2076

Polymorphism and mutation databases

BioMutaiMAP3K19
DMDMi74755104

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326401 – 1328Mitogen-activated protein kinase kinase kinase 19Add BLAST1328

Proteomic databases

MaxQBiQ56UN5
PaxDbiQ56UN5
PeptideAtlasiQ56UN5
PRIDEiQ56UN5
ProteomicsDBi62584
62585 [Q56UN5-2]
62586 [Q56UN5-3]
62587 [Q56UN5-4]
62588 [Q56UN5-5]
62589 [Q56UN5-6]

PTM databases

iPTMnetiQ56UN5
PhosphoSitePlusiQ56UN5

Expressioni

Gene expression databases

BgeeiENSG00000176601
CleanExiHS_YSK4
ExpressionAtlasiQ56UN5 baseline and differential
GenevisibleiQ56UN5 HS

Organism-specific databases

HPAiHPA011388

Interactioni

Protein-protein interaction databases

BioGridi123124, 1 interactor
STRINGi9606.ENSP00000365005

Chemistry databases

BindingDBiQ56UN5

Structurei

3D structure databases

ProteinModelPortaliQ56UN5
SMRiQ56UN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1061 – 1324Protein kinasePROSITE-ProRule annotationAdd BLAST264

Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0198 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00800000124036
HOVERGENiHBG094170
InParanoidiQ56UN5
KOiK17533
OMAiRDQHERP
OrthoDBiEOG091G0AR6
PhylomeDBiQ56UN5
TreeFamiTF332735

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q56UN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ 
        60         70         80         90        100
DGDCSHSTLV NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED 
       110        120        130        140        150
LKEKNLINSS LQEWAQAHAV SHPNEIETVE LRKKKLTMRP LVLQKEESSR 
       160        170        180        190        200
ELCNVNLGFL LPRSCLELNI SKSVTREDAP HFLKEQQRKS EEFSTSHMKY 
       210        220        230        240        250
SGRSIKFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS LTSFVPKLSV 
       260        270        280        290        300
SVRQSDELSP SNEPPGALVK SLMDPTLRSS DGFIWSRNMC SFPKTNHHRQ 
       310        320        330        340        350
CLEKEENWKS KEIEECNKIE ITHFEKGQSL VSFENLKEGN IPAVREEDID 
       360        370        380        390        400
CHGSKTRKPE EENSQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS 
       410        420        430        440        450
EITPSQDEEM RNNKAASKRV SLHKNEAMEP NNILEECTVL KSLSSVVFDD 
       460        470        480        490        500
PIDKLPEGCS SMETNIKISI AERAKPEMSR MVPLIHITFP VDGSPKEPVI 
       510        520        530        540        550
AKPSLQTRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS KTKTSKKTPQ 
       560        570        580        590        600
NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK 
       610        620        630        640        650
QSTHRTQKPK KQSFPCICKN PGTQKSCVPL SVQPTEPRLN YLDLKYSDMF 
       660        670        680        690        700
KEINSTANGP GIYEMFGTPV YCHVRETERD ENTYYREICS APSGRRITNK 
       710        720        730        740        750
CRSSHSERKS NIRTRLSQKK THMKCPKTSF GIKQEHKVLI SKEKSSKAVH 
       760        770        780        790        800
SNLHDIENGD GISEPDWQIK SSGNEFLSSK DEIHPMNLAQ TPEQSMKQNE 
       810        820        830        840        850
FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL EELHHQIPFI 
       860        870        880        890        900
PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS 
       910        920        930        940        950
KTLTNFSFQA KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN 
       960        970        980        990       1000
SISQEIMDSV NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL 
      1010       1020       1030       1040       1050
NLVLRWRGST PKEMGRETTK VKIQRHSSGL RIYDREEKFL ISNEKKIFSE 
      1060       1070       1080       1090       1100
NSLKSEEPIL WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSNKLA 
      1110       1120       1130       1140       1150
AEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM EFVPGGSISS 
      1160       1170       1180       1190       1200
IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII 
      1210       1220       1230       1240       1250
KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI 
      1260       1270       1280       1290       1300
WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF 
      1310       1320 
VRMCLTRDQH ERPSALQLLK HSFLERSH
Length:1,328
Mass (Da):150,537
Last modified:May 10, 2005 - v1
Checksum:i10E225EDB1EF4FA3
GO
Isoform 2 (identifier: Q56UN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1122-1127: NIVAYL → PDQGPA
     1128-1328: Missing.

Show »
Length:1,127
Mass (Da):127,941
Checksum:iB031EFB739B3B28B
GO
Isoform 3 (identifier: Q56UN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-191: Missing.

Show »
Length:1,215
Mass (Da):137,548
Checksum:iF0197C84572ED393
GO
Isoform 4 (identifier: Q56UN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.
     1064-1111: Missing.

Show »
Length:462
Mass (Da):52,504
Checksum:i123177F7965C4C64
GO
Isoform 5 (identifier: Q56UN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.

Show »
Length:510
Mass (Da):57,659
Checksum:i27E67C237A50AD36
GO
Isoform 6 (identifier: Q56UN5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1139: Missing.
     1308-1328: Missing.

Show »
Length:168
Mass (Da):18,702
Checksum:iA9B594F15FE13CA9
GO
Isoform 7 (identifier: Q56UN5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1074: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):51,920
Checksum:i2B40C5FC91E2D11B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1235A → V in BAB15538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051687438T → I. Corresponds to variant dbSNP:rs16831235Ensembl.1
Natural variantiVAR_041334500I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_051688676E → Q. Corresponds to variant dbSNP:rs1112542Ensembl.1
Natural variantiVAR_051689812E → G. Corresponds to variant dbSNP:rs3905317Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0179221 – 1139Missing in isoform 6. 2 PublicationsAdd BLAST1139
Alternative sequenceiVSP_01792479 – 191Missing in isoform 3. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_055367207 – 1074Missing in isoform 7. 1 PublicationAdd BLAST868
Alternative sequenceiVSP_017925207 – 1024Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST818
Alternative sequenceiVSP_0179261064 – 1111Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0179271122 – 1127NIVAYL → PDQGPA in isoform 2. 1 Publication6
Alternative sequenceiVSP_0179281128 – 1328Missing in isoform 2. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_0179231308 – 1328Missing in isoform 6. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574901 mRNA Translation: AAT81410.1
AY574902 mRNA Translation: AAT81411.1
AY574903 mRNA Translation: AAT81412.1
AY574904 mRNA Translation: AAT81413.1
AY574905 mRNA Translation: AAT81414.1
AK026727 mRNA Translation: BAB15538.1
AC016725 Genomic DNA Translation: AAY14999.1
AC020602 Genomic DNA No translation available.
BC034417 mRNA Translation: AAH34417.1
BC137276 mRNA Translation: AAI37277.1
BC137277 mRNA Translation: AAI37278.1
BC144555 mRNA Translation: AAI44556.1
CCDSiCCDS2176.2 [Q56UN5-1]
CCDS33293.1 [Q56UN5-5]
CCDS63020.1 [Q56UN5-3]
CCDS63021.1 [Q56UN5-7]
CCDS63022.1 [Q56UN5-4]
RefSeqiNP_001018054.1, NM_001018044.2 [Q56UN5-3]
NP_001018056.1, NM_001018046.2 [Q56UN5-5]
NP_001018057.1, NM_001018047.2 [Q56UN5-4]
NP_001269812.1, NM_001282883.1 [Q56UN5-7]
NP_001308106.1, NM_001321177.1
NP_079328.3, NM_025052.4
XP_011510194.1, XM_011511892.1 [Q56UN5-1]
XP_016860492.1, XM_017005003.1 [Q56UN5-1]
UniGeneiHs.659395

Genome annotation databases

EnsembliENST00000358371; ENSP00000351140; ENSG00000176601 [Q56UN5-3]
ENST00000375844; ENSP00000365004; ENSG00000176601 [Q56UN5-5]
ENST00000375845; ENSP00000365005; ENSG00000176601 [Q56UN5-1]
ENST00000392915; ENSP00000376647; ENSG00000176601 [Q56UN5-1]
ENST00000392917; ENSP00000376649; ENSG00000176601 [Q56UN5-7]
ENST00000392918; ENSP00000376650; ENSG00000176601 [Q56UN5-4]
GeneIDi80122
KEGGihsa:80122
UCSCiuc002tue.2 human [Q56UN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiM3K19_HUMAN
AccessioniPrimary (citable) accession number: Q56UN5
Secondary accession number(s): B2RP57
, B7ZMH9, E2QRE3, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 10, 2005
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

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