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UniProtKB - Q56UN5 (M3K19_HUMAN)

Entry version 141 (02 Jun 2021)
Sequence version 1 (10 May 2005)
Previous versions | rss
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Protein

Mitogen-activated protein kinase kinase kinase 19

Gene

MAP3K19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1089ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1067 – 1075ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q56UN5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q56UN5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 19 (EC:2.7.11.1)
Alternative name(s):
Regulated in COPD, protein kinase
SPS1/STE20-related protein kinase YSK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP3K19
Synonyms:RCK, YSK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26249, MAP3K19

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q56UN5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000176601.11

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80122

Open Targets

More...OpenTargetsi		ENSG00000176601

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670554

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q56UN5, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6191

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		Q56UN5

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2076

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAP3K19

Domain mapping of disease mutations (DMDM)

More...DMDMi		74755104

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002326401 – 1328Mitogen-activated protein kinase kinase kinase 19Add BLAST1328

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q56UN5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q56UN5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q56UN5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q56UN5

PeptideAtlas

More...PeptideAtlasi		Q56UN5

PRoteomics IDEntifications database

More...PRIDEi		Q56UN5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62584 [Q56UN5-1]
62586 [Q56UN5-3]
62587 [Q56UN5-4]
62588 [Q56UN5-5]
7260

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q56UN5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q56UN5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000176601, Expressed in bronchial epithelial cell and 119 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q56UN5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q56UN5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000176601, Tissue enhanced (brain, fallopian tube)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123124, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q56UN5, 1 interactor

Molecular INTeraction database

More...MINTi		Q56UN5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365005

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q56UN5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q56UN5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q56UN5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1061 – 1324Protein kinasePROSITE-ProRule annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni44 – 74DisorderedSequence analysisAdd BLAST31
Regioni344 – 380DisorderedSequence analysisAdd BLAST37
Regioni524 – 561DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 71Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi344 – 367Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi524 – 544Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi545 – 561Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0198, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160383

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_599846_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q56UN5

Identification of Orthologs from Complete Genome Data

More...OMAi		RMPQIEK

Database of Orthologous Groups

More...OrthoDBi		55144at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q56UN5

TreeFam database of animal gene trees

More...TreeFami		TF332735

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q56UN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ 
        60         70         80         90        100
DGDCSHSTLV NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED 
       110        120        130        140        150
LKEKNLINSS LQEWAQAHAV SHPNEIETVE LRKKKLTMRP LVLQKEESSR 
       160        170        180        190        200
ELCNVNLGFL LPRSCLELNI SKSVTREDAP HFLKEQQRKS EEFSTSHMKY 
       210        220        230        240        250
SGRSIKFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS LTSFVPKLSV 
       260        270        280        290        300
SVRQSDELSP SNEPPGALVK SLMDPTLRSS DGFIWSRNMC SFPKTNHHRQ 
       310        320        330        340        350
CLEKEENWKS KEIEECNKIE ITHFEKGQSL VSFENLKEGN IPAVREEDID 
       360        370        380        390        400
CHGSKTRKPE EENSQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS 
       410        420        430        440        450
EITPSQDEEM RNNKAASKRV SLHKNEAMEP NNILEECTVL KSLSSVVFDD 
       460        470        480        490        500
PIDKLPEGCS SMETNIKISI AERAKPEMSR MVPLIHITFP VDGSPKEPVI 
       510        520        530        540        550
AKPSLQTRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS KTKTSKKTPQ 
       560        570        580        590        600
NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK 
       610        620        630        640        650
QSTHRTQKPK KQSFPCICKN PGTQKSCVPL SVQPTEPRLN YLDLKYSDMF 
       660        670        680        690        700
KEINSTANGP GIYEMFGTPV YCHVRETERD ENTYYREICS APSGRRITNK 
       710        720        730        740        750
CRSSHSERKS NIRTRLSQKK THMKCPKTSF GIKQEHKVLI SKEKSSKAVH 
       760        770        780        790        800
SNLHDIENGD GISEPDWQIK SSGNEFLSSK DEIHPMNLAQ TPEQSMKQNE 
       810        820        830        840        850
FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL EELHHQIPFI 
       860        870        880        890        900
PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS 
       910        920        930        940        950
KTLTNFSFQA KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN 
       960        970        980        990       1000
SISQEIMDSV NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL 
      1010       1020       1030       1040       1050
NLVLRWRGST PKEMGRETTK VKIQRHSSGL RIYDREEKFL ISNEKKIFSE 
      1060       1070       1080       1090       1100
NSLKSEEPIL WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSNKLA 
      1110       1120       1130       1140       1150
AEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM EFVPGGSISS 
      1160       1170       1180       1190       1200
IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII 
      1210       1220       1230       1240       1250
KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI 
      1260       1270       1280       1290       1300
WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF 
      1310       1320 
VRMCLTRDQH ERPSALQLLK HSFLERSH
Length:1,328
Mass (Da):150,537
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10E225EDB1EF4FA3
GO
Isoform 3 (identifier: Q56UN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-191: Missing.

Show »
Length:1,215
Mass (Da):137,548
Checksum:iF0197C84572ED393
GO
Isoform 4 (identifier: Q56UN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.
     1064-1111: Missing.

Show »
Length:462
Mass (Da):52,504
Checksum:i123177F7965C4C64
GO
Isoform 5 (identifier: Q56UN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.

Show »
Length:510
Mass (Da):57,659
Checksum:i27E67C237A50AD36
GO
Isoform 7 (identifier: Q56UN5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1074: Missing.

Show »
Length:460
Mass (Da):51,920
Checksum:i2B40C5FC91E2D11B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C041H7C041_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
697Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTF4A0A1B0GTF4_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
910Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJK1A0A590UJK1_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJV9A0A590UJV9_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGQ2C9JGQ2_HUMAN
Mitogen-activated protein kinase ki...
MAP3K19
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAT81412 differs from that shown. Non-canonical splice intron-exon junction.Curated
The sequence BAB15538 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1073 – 1074GT → RE in AAH34417 (PubMed:15489334).Curated2
Sequence conflicti1235A → V in BAB15538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051687438T → I. Corresponds to variant dbSNP:rs16831235Ensembl.1
Natural variantiVAR_041334500I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_051688676E → Q. Corresponds to variant dbSNP:rs1112542Ensembl.1
Natural variantiVAR_051689812E → G. Corresponds to variant dbSNP:rs3905317Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01792479 – 191Missing in isoform 3. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_055367207 – 1074Missing in isoform 7. 1 PublicationAdd BLAST868
Alternative sequenceiVSP_017925207 – 1024Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST818
Alternative sequenceiVSP_0179261064 – 1111Missing in isoform 4. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY574901 mRNA Translation: AAT81410.1
AY574902 mRNA Translation: AAT81411.1
AY574903 mRNA Translation: AAT81412.1 Sequence problems.
AY574904 mRNA Translation: AAT81413.1
AY574905 mRNA Translation: AAT81414.1
AK026727 mRNA Translation: BAB15538.1 Different initiation.
AC016725 Genomic DNA Translation: AAY14999.1
AC020602 Genomic DNA No translation available.
BC034417 mRNA Translation: AAH34417.1
BC137276 mRNA Translation: AAI37277.1
BC137277 mRNA Translation: AAI37278.1
BC144555 mRNA Translation: AAI44556.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2176.2 [Q56UN5-1]
CCDS33293.1 [Q56UN5-5]
CCDS63020.1 [Q56UN5-3]
CCDS63021.1 [Q56UN5-7]
CCDS63022.1 [Q56UN5-4]

NCBI Reference Sequences

More...RefSeqi		NP_001018054.1, NM_001018044.2 [Q56UN5-3]
NP_001018056.1, NM_001018046.2 [Q56UN5-5]
NP_001018057.1, NM_001018047.2 [Q56UN5-4]
NP_001269812.1, NM_001282883.1 [Q56UN5-7]
NP_001308106.1, NM_001321177.1
NP_079328.3, NM_025052.4 [Q56UN5-1]
XP_011510194.1, XM_011511892.1 [Q56UN5-1]
XP_016860492.1, XM_017005003.1 [Q56UN5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000358371; ENSP00000351140; ENSG00000176601 [Q56UN5-3]
ENST00000375844; ENSP00000365004; ENSG00000176601 [Q56UN5-5]
ENST00000375845; ENSP00000365005; ENSG00000176601 [Q56UN5-1]
ENST00000392915; ENSP00000376647; ENSG00000176601 [Q56UN5-1]
ENST00000392917; ENSP00000376649; ENSG00000176601 [Q56UN5-7]
ENST00000392918; ENSP00000376650; ENSG00000176601 [Q56UN5-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80122

UCSC genome browser

More...UCSCi		uc002tue.2, human [Q56UN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574901 mRNA Translation: AAT81410.1
AY574902 mRNA Translation: AAT81411.1
AY574903 mRNA Translation: AAT81412.1 Sequence problems.
AY574904 mRNA Translation: AAT81413.1
AY574905 mRNA Translation: AAT81414.1
AK026727 mRNA Translation: BAB15538.1 Different initiation.
AC016725 Genomic DNA Translation: AAY14999.1
AC020602 Genomic DNA No translation available.
BC034417 mRNA Translation: AAH34417.1
BC137276 mRNA Translation: AAI37277.1
BC137277 mRNA Translation: AAI37278.1
BC144555 mRNA Translation: AAI44556.1
CCDSiCCDS2176.2 [Q56UN5-1]
CCDS33293.1 [Q56UN5-5]
CCDS63020.1 [Q56UN5-3]
CCDS63021.1 [Q56UN5-7]
CCDS63022.1 [Q56UN5-4]
RefSeqiNP_001018054.1, NM_001018044.2 [Q56UN5-3]
NP_001018056.1, NM_001018046.2 [Q56UN5-5]
NP_001018057.1, NM_001018047.2 [Q56UN5-4]
NP_001269812.1, NM_001282883.1 [Q56UN5-7]
NP_001308106.1, NM_001321177.1
NP_079328.3, NM_025052.4 [Q56UN5-1]
XP_011510194.1, XM_011511892.1 [Q56UN5-1]
XP_016860492.1, XM_017005003.1 [Q56UN5-1]

3D structure databases

SMRiQ56UN5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123124, 2 interactors
IntActiQ56UN5, 1 interactor
MINTiQ56UN5
STRINGi9606.ENSP00000365005

Chemistry databases

BindingDBiQ56UN5
ChEMBLiCHEMBL6191
DrugBankiDB12010, Fostamatinib
DrugCentraliQ56UN5
GuidetoPHARMACOLOGYi2076

PTM databases

iPTMnetiQ56UN5
PhosphoSitePlusiQ56UN5

Genetic variation databases

BioMutaiMAP3K19
DMDMi74755104

Proteomic databases

jPOSTiQ56UN5
MassIVEiQ56UN5
MaxQBiQ56UN5
PaxDbiQ56UN5
PeptideAtlasiQ56UN5
PRIDEiQ56UN5
ProteomicsDBi62584 [Q56UN5-1]
62586 [Q56UN5-3]
62587 [Q56UN5-4]
62588 [Q56UN5-5]
7260

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2102, 53 antibodies

The DNASU plasmid repository

More...DNASUi		80122

Genome annotation databases

EnsembliENST00000358371; ENSP00000351140; ENSG00000176601 [Q56UN5-3]
ENST00000375844; ENSP00000365004; ENSG00000176601 [Q56UN5-5]
ENST00000375845; ENSP00000365005; ENSG00000176601 [Q56UN5-1]
ENST00000392915; ENSP00000376647; ENSG00000176601 [Q56UN5-1]
ENST00000392917; ENSP00000376649; ENSG00000176601 [Q56UN5-7]
ENST00000392918; ENSP00000376650; ENSG00000176601 [Q56UN5-4]
GeneIDi80122
KEGGihsa:80122
UCSCiuc002tue.2, human [Q56UN5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80122
DisGeNETi80122

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAP3K19
HGNCiHGNC:26249, MAP3K19
HPAiENSG00000176601, Tissue enhanced (brain, fallopian tube)
neXtProtiNX_Q56UN5
OpenTargetsiENSG00000176601
PharmGKBiPA142670554
VEuPathDBiHostDB:ENSG00000176601.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0198, Eukaryota
GeneTreeiENSGT00940000160383
HOGENOMiCLU_599846_0_0_1
InParanoidiQ56UN5
OMAiRMPQIEK
OrthoDBi55144at2759
PhylomeDBiQ56UN5
TreeFamiTF332735

Enzyme and pathway databases

PathwayCommonsiQ56UN5
SignaLinkiQ56UN5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80122, 6 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAP3K19, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80122
PharosiQ56UN5, Tchem

Protein Ontology

More...PROi		PR:Q56UN5
RNActiQ56UN5, protein

Gene expression databases

BgeeiENSG00000176601, Expressed in bronchial epithelial cell and 119 other tissues
ExpressionAtlasiQ56UN5, baseline and differential
GenevisibleiQ56UN5, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3K19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q56UN5
Secondary accession number(s): B2RP57
, B7ZMH9, E2QRE3, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 10, 2005
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. SIMILARITY comments
    Index of protein domains and families
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