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Protein

Sodium channel protein

Gene

NaV1.4

Organism
Thamnophis sirtalis
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:NaV1.4Imported
OrganismiThamnophis sirtalisImported
Taxonomic identifieri35019 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaColubridaeNatricinaeThamnophis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei125 – 148HelicalUniRule annotationAdd BLAST24
Transmembranei193 – 212HelicalUniRule annotationAdd BLAST20
Transmembranei224 – 245HelicalUniRule annotationAdd BLAST22
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21
Transmembranei376 – 393HelicalUniRule annotationAdd BLAST18
Transmembranei413 – 440HelicalUniRule annotationAdd BLAST28
Transmembranei616 – 634HelicalUniRule annotationAdd BLAST19
Transmembranei646 – 669HelicalUniRule annotationAdd BLAST24
Transmembranei681 – 705HelicalUniRule annotationAdd BLAST25
Transmembranei726 – 754HelicalUniRule annotationAdd BLAST29
Transmembranei816 – 839HelicalUniRule annotationAdd BLAST24
Transmembranei1058 – 1076HelicalUniRule annotationAdd BLAST19
Transmembranei1097 – 1119HelicalUniRule annotationAdd BLAST23
Transmembranei1125 – 1145HelicalUniRule annotationAdd BLAST21
Transmembranei1174 – 1200HelicalUniRule annotationAdd BLAST27
Transmembranei1301 – 1324HelicalUniRule annotationAdd BLAST24
Transmembranei1383 – 1401HelicalUniRule annotationAdd BLAST19
Transmembranei1413 – 1435HelicalUniRule annotationAdd BLAST23
Transmembranei1447 – 1466HelicalUniRule annotationAdd BLAST20
Transmembranei1500 – 1528HelicalUniRule annotationAdd BLAST29
Transmembranei1604 – 1627HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ56PC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 446Ion_transInterPro annotationAdd BLAST319
Domaini617 – 843Ion_transInterPro annotationAdd BLAST227
Domaini853 – 1052Na_trans_assocInterPro annotationAdd BLAST200
Domaini1056 – 1332Ion_transInterPro annotationAdd BLAST277
Domaini1382 – 1637Ion_transInterPro annotationAdd BLAST256

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili26 – 49Sequence analysisAdd BLAST24
Coiled coili444 – 478Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG053100

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q56PC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVPYIPGP DCLRPFTRES LKAIEKRIAE REAEKLKNQH EKVLDEEKQP
60 70 80 90 100
KPRCDLEQGK GLPLIYGEPP PELIGVPLED LDTFYSDQKT YIILNKGNTI
110 120 130 140 150
FRFTAAPALY MLDPFNPIRN GAIKVLTHSL FSMFIMITIL ANCVFMTMSN
160 170 180 190 200
PPIWAKDVEY TFTGIYTFEA MIKVLARGFC IDSLTFLRDP WNWLDFSVIV
210 220 230 240 250
MAYVTEFVDL GNVSALRTFR VLRALKTITV IPGLKTIVGA LIQSVKKLAD
260 270 280 290 300
VMILTVFCLA VFALIGLQLF MGNLRQKCVR WPPFSNDTLQ DALGPSFTSD
310 320 330 340 350
SLQDVLWRDP LDNSTLNDNF TLTGTFDWHE YINNEDNFYF LDGALDALLC
360 370 380 390 400
GNSSDAGQCP EGFLCMKAGR NPNYGYTSYD TFSWAFLSLF RLMTQDYWEN
410 420 430 440 450
LFQLTLRAAG KTYMIFFVVI IFLGSFYLIN LILAVVAMAY AEQNDATLQE
460 470 480 490 500
EKEKEEEFQQ MVEQLKKHQE EQQRLLQAQT ATNSSAESII VEKKQKGELD
510 520 530 540 550
EKAQSDQEGP KDCNGRAIPR LVLERSATVR ESNPREEHEK SRQNHLYVDG
560 570 580 590 600
VEGKGLEKRV GSAVSVVSST LEELEEAHQK CPPWWYKFAH AVLIWNCCPV
610 620 630 640 650
WVKLKHIIKL IVLDPFVDLG ITICIVLNTV FMAMEHYPMT EEFNNVLNVG
660 670 680 690 700
NLVFTGIFTA EMVLKLIALD PYEYFQIGWN IFDSIIVTLS LVELGLANVQ
710 720 730 740 750
GLSVLRSFRL MRVSKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI
760 770 780 790 800
FAVVGMQLFG KNYIECVCKI SSDCELPRWH MHDFFHSFLI VFRILCGEWI
810 820 830 840 850
ETMWDCMEVA GQPMCLIVFL MVMVIGNLVV LNLFLALLLS SFSADSLAGS
860 870 880 890 900
DDDSEMNNLQ IAIGKINRGI DFVKKHVLLL LHRELKEKTE LSSEEPDDSK
910 920 930 940 950
KENFVLNHMD NLNHVDTGQD FKSEYMDGIV KNEQLIDELG QMNFINNPNL
960 970 980 990 1000
TINVPIASEE SDLYDETDTG EETADDIKKP LSDGTDSSIC STVDYKPPDP
1010 1020 1030 1040 1050
SEEKAEVEEN MENDDPEECF TEACVQRCPF LYVDIKTEKG AKWWNLRKAC
1060 1070 1080 1090 1100
FKIVEHNWFE TFIIFMILLS SGALAFEDIY IERRHTIRTI LEYADKIFTY
1110 1120 1130 1140 1150
VFILEMLLKW VAYGFKVYFT NAWCWLDFLI VDVSLISLTA NWLGYSELGA
1160 1170 1180 1190 1200
IKSLRTLRAL RPLRALSRFE GMRVVVNALL GAIPSIMNVL LVCLIFWLIF
1210 1220 1230 1240 1250
SIMGVNLFAG KYYRCVNTTT GDLFEIEHVN NKSDCINLIN IENATDVRWV
1260 1270 1280 1290 1300
NVKVNFDNVG LGYLSLLQVA TFKGWMDIMY AAVDSREQEE QPQYEVNLYM
1310 1320 1330 1340 1350
YIYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGKDIF MTEEQKKYYN
1360 1370 1380 1390 1400
AMKKLGSKKP VKPIPRPQNK YQGMIFDFVT QQAFDIIIMI LICLNMVTMM
1410 1420 1430 1440 1450
VETDDQSQTK ITILAQINLV FIIIFTSECF LKMIALRHYF FTNGWNIFDF
1460 1470 1480 1490 1500
VVVILSIVGL VLSDIIEKYF VSPTLFRVIR LARIGRVLRL IRGAKGIRTL
1510 1520 1530 1540 1550
LFALMMSLPA LFNIGLLLFL VMFIYSIFGM SNFAYVKKES GIDDIFNFET
1560 1570 1580 1590 1600
FGNSILCLFE VTTSAGWNVL LNPILNSVPP DCDPHLDNPG SHVKGDCGNP
1610 1620 1630 1640 1650
SMGICFFCSY IIVSFLIVVN MYIAIILENF NVATEESSEP LCEDDFEMFY
1660 1670 1680 1690 1700
ETWEKFDPDA TQFIAYSTLS DFVDTLQEPL RIAKPNKIKL ITLDLPMVPG
1710 1720 1730 1740 1750
DKIHCLDILF ALTKEVLGDS GEMDALKQSM EEKFMAANPS KVSYEPITTT
1760 1770 1780 1790 1800
LKRKQEEVCA IKIQRAFRRY LLKRSVKQAS YLYRQSQDMD IPKENAPGKE
1810 1820 1830 1840 1850
GMIANKMNAM YSSQVEVEKS PETAPSPVLE PLSSPEIKKD AGEMKEQDNN
1860 1870
GKEGDDSGKT KKSENAKRGV KESSV
Length:1,875
Mass (Da):213,580
Last modified:May 10, 2005 - v1
Checksum:i8B56071C293A8CCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY851746 mRNA Translation: AAW68224.1

Similar proteinsi

Entry informationi

Entry nameiQ56PC4_9SAUR
AccessioniPrimary (citable) accession number: Q56PC4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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