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Protein

Pyrin domain-containing protein 2

Gene

PYDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17339483, PubMed:17178784). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464).3 Publications

Caution

Absent from the genome of domestic mammals and New World monkeys it is found in the genome of hominids and Old World monkeys. Likely derived from retrogene insertion of an NLRP2/NLRP7-like gene, it has probably arisen recently in the mammalian genomes where it is under purifying selection.1 Publication

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrin domain-containing protein 2Curated
Alternative name(s):
Pyrin-only protein 21 Publication
cellular POP21 Publication
Short name:
cPOP21 Publication
Gene namesi
Name:PYDC2Imported
Synonyms:POP21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000253548.1
HGNCiHGNC:33512 PYDC2
MIMi615701 gene
neXtProtiNX_Q56P42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi152138
PharmGKBiPA162400524

Polymorphism and mutation databases

BioMutaiPYDC2
DMDMi74721597

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003484271 – 97Pyrin domain-containing protein 2Add BLAST97

Proteomic databases

PaxDbiQ56P42
PeptideAtlasiQ56P42
PRIDEiQ56P42
ProteomicsDBi62583

Expressioni

Tissue specificityi

Predominantly expressed in peripheral blood. Weakly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000253548 Expressed in 18 organ(s), highest expression level in urinary bladder
CleanExiHS_PYDC2

Organism-specific databases

HPAiHPA055895

Interactioni

Subunit structurei

Interacts with PYCARD/ASC (via pyrin domain) (PubMed:17339483, PubMed:17178784). Interacts with NLRP2 (via pyrin domain) (PubMed:17178784).2 Publications

Binary interactionsi

Protein-protein interaction databases

IntActiQ56P42, 5 interactors
STRINGi9606.ENSP00000428325

Structurei

3D structure databases

ProteinModelPortaliQ56P42
SMRiQ56P42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 94PyrinPROSITE-ProRule annotationAdd BLAST94

Phylogenomic databases

eggNOGiENOG410ITCB Eukaryota
ENOG4110PZ0 LUCA
GeneTreeiENSGT00390000008721
HOGENOMiHOG000115808
InParanoidiQ56P42
KOiK20911
OrthoDBiEOG091G01Q7
PhylomeDBiQ56P42

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q56P42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSAELDFN LQALLEQLSQ DELSKFKSLI RTISLGKELQ TVPQTEVDKA
60 70 80 90
NGKQLVEIFT SHSCSYWAGM AAIQVFEKMN QTHLSGRADE HCVMPPP
Length:97
Mass (Da):10,795
Last modified:May 10, 2005 - v1
Checksum:iE2EE7A27FB90E586
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04615081Q → R. Corresponds to variant dbSNP:rs293833Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY858112 mRNA Translation: AAX54598.1
RefSeqiNP_001076777.1, NM_001083308.1
UniGeneiHs.690618

Genome annotation databases

EnsembliENST00000518817; ENSP00000492367; ENSG00000253548
GeneIDi152138
KEGGihsa:152138
UCSCiuc011bso.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY858112 mRNA Translation: AAX54598.1
RefSeqiNP_001076777.1, NM_001083308.1
UniGeneiHs.690618

3D structure databases

ProteinModelPortaliQ56P42
SMRiQ56P42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ56P42, 5 interactors
STRINGi9606.ENSP00000428325

Polymorphism and mutation databases

BioMutaiPYDC2
DMDMi74721597

Proteomic databases

PaxDbiQ56P42
PeptideAtlasiQ56P42
PRIDEiQ56P42
ProteomicsDBi62583

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518817; ENSP00000492367; ENSG00000253548
GeneIDi152138
KEGGihsa:152138
UCSCiuc011bso.2 human

Organism-specific databases

CTDi152138
DisGeNETi152138
EuPathDBiHostDB:ENSG00000253548.1
GeneCardsiPYDC2
HGNCiHGNC:33512 PYDC2
HPAiHPA055895
MIMi615701 gene
neXtProtiNX_Q56P42
PharmGKBiPA162400524
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITCB Eukaryota
ENOG4110PZ0 LUCA
GeneTreeiENSGT00390000008721
HOGENOMiHOG000115808
InParanoidiQ56P42
KOiK20911
OrthoDBiEOG091G01Q7
PhylomeDBiQ56P42

Miscellaneous databases

GenomeRNAii152138
PROiPR:Q56P42
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000253548 Expressed in 18 organ(s), highest expression level in urinary bladder
CleanExiHS_PYDC2

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYDC2_HUMAN
AccessioniPrimary (citable) accession number: Q56P42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 10, 2005
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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