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Protein

E2F-associated phosphoprotein

Gene

EAPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.1 Publication

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ56P03

Names & Taxonomyi

Protein namesi
Recommended name:
E2F-associated phosphoprotein
Short name:
EAPP
Gene namesi
Name:EAPP
Synonyms:C14orf11
ORF Names:BM-036
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000129518.8
HGNCiHGNC:19312 EAPP
MIMi609486 gene
neXtProtiNX_Q56P03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129518
PharmGKBiPA162384208

Polymorphism and mutation databases

BioMutaiEAPP
DMDMi296439474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869041 – 285E2F-associated phosphoproteinAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ56P03
MaxQBiQ56P03
PaxDbiQ56P03
PeptideAtlasiQ56P03
PRIDEiQ56P03
ProteomicsDBi62582

PTM databases

iPTMnetiQ56P03
PhosphoSitePlusiQ56P03

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.2 Publications

Developmental stagei

During the cell cycle, expression disappears during mitosis.

Gene expression databases

BgeeiENSG00000129518 Expressed in 234 organ(s), highest expression level in kidney
CleanExiHS_EAPP
ExpressionAtlasiQ56P03 baseline and differential
GenevisibleiQ56P03 HS

Organism-specific databases

HPAiHPA002916

Interactioni

Subunit structurei

Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4.1 Publication

Protein-protein interaction databases

BioGridi120941, 49 interactors
IntActiQ56P03, 7 interactors
STRINGi9606.ENSP00000250454

Structurei

3D structure databases

ProteinModelPortaliQ56P03
SMRiQ56P03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 127Poly-Lys6

Phylogenomic databases

eggNOGiKOG3395 Eukaryota
ENOG4110B8Q LUCA
GeneTreeiENSGT00390000001332
HOGENOMiHOG000068005
HOVERGENiHBG054593
InParanoidiQ56P03
OMAiKYRTQYR
OrthoDBiEOG091G0BO0
PhylomeDBiQ56P03
TreeFamiTF328497

Family and domain databases

InterProiView protein in InterPro
IPR019370 E2F-assoc_phosphoprotein
PANTHERiPTHR15967 PTHR15967, 1 hit
PfamiView protein in Pfam
PF10238 Eapp_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q56P03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRLPDDYDP YAVEEPSDEE PALSSSEDEV DVLLHGTPDQ KRKLIRECLT
60 70 80 90 100
GESESSSEDE FEKEMEAELN STMKTMEDKL SSLGTGSSSG NGKVATAPTR
110 120 130 140 150
YYDDIYFDSD SEDEDRAVQV TKKKKKKQHK IPTNDELLYD PEKDNRDQAW
160 170 180 190 200
VDAQRRGYHG LGPQRSRQQQ PVPNSDAVLN CPACMTTLCL DCQRHESYKT
210 220 230 240 250
QYRAMFVMNC SINKEEVLRY KASENRKKRR VHKKMRSNRE DAAEKAETDV
260 270 280
EEIYHPVMCT ECSTEVAVYD KDEVFHFFNV LASHS
Length:285
Mass (Da):32,762
Last modified:May 18, 2010 - v4
Checksum:i1C0691602FFB516A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2W9G3V2W9_HUMAN
E2F-associated phosphoprotein
EAPP
205Annotation score:
A0A087X060A0A087X060_HUMAN
E2F-associated phosphoprotein
EAPP
231Annotation score:
G3V5N6G3V5N6_HUMAN
E2F-associated phosphoprotein
EAPP
109Annotation score:

Sequence cautioni

The sequence AAF67623 differs from that shown. Reason: Frameshift at positions 178, 189, 198 and 226.Curated
The sequence AAO17041 differs from that shown. Reason: Frameshift at positions 178, 189, 198 and 226.Curated
The sequence AAO17042 differs from that shown. Reason: Frameshift at positions 178, 189, 198 and 226.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → L in AAX63200 (PubMed:15716352).Curated1
Sequence conflicti52E → G in BAA91271 (PubMed:14702039).Curated1
Sequence conflicti239R → Q in AAX63200 (PubMed:15716352).Curated1
Sequence conflicti239R → Q in AAH01245 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031915168Q → E2 PublicationsCorresponds to variant dbSNP:rs17352411Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157300 mRNA Translation: AAO17041.1 Frameshift.
AY157301 mRNA Translation: AAO17042.1 Frameshift.
AY869694 mRNA Translation: AAX63200.1
AF217512 mRNA Translation: AAF67623.1 Frameshift.
AK000585 mRNA Translation: BAA91271.1
AL445363 Genomic DNA No translation available.
BC001245 mRNA Translation: AAH01245.1
CCDSiCCDS41941.1
RefSeqiNP_001305845.1, NM_001318916.1
NP_060923.2, NM_018453.3
UniGeneiHs.433269

Genome annotation databases

EnsembliENST00000250454; ENSP00000250454; ENSG00000129518
GeneIDi55837
KEGGihsa:55837
UCSCiuc001wsd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157300 mRNA Translation: AAO17041.1 Frameshift.
AY157301 mRNA Translation: AAO17042.1 Frameshift.
AY869694 mRNA Translation: AAX63200.1
AF217512 mRNA Translation: AAF67623.1 Frameshift.
AK000585 mRNA Translation: BAA91271.1
AL445363 Genomic DNA No translation available.
BC001245 mRNA Translation: AAH01245.1
CCDSiCCDS41941.1
RefSeqiNP_001305845.1, NM_001318916.1
NP_060923.2, NM_018453.3
UniGeneiHs.433269

3D structure databases

ProteinModelPortaliQ56P03
SMRiQ56P03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120941, 49 interactors
IntActiQ56P03, 7 interactors
STRINGi9606.ENSP00000250454

PTM databases

iPTMnetiQ56P03
PhosphoSitePlusiQ56P03

Polymorphism and mutation databases

BioMutaiEAPP
DMDMi296439474

Proteomic databases

EPDiQ56P03
MaxQBiQ56P03
PaxDbiQ56P03
PeptideAtlasiQ56P03
PRIDEiQ56P03
ProteomicsDBi62582

Protocols and materials databases

DNASUi55837
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250454; ENSP00000250454; ENSG00000129518
GeneIDi55837
KEGGihsa:55837
UCSCiuc001wsd.2 human

Organism-specific databases

CTDi55837
EuPathDBiHostDB:ENSG00000129518.8
GeneCardsiEAPP
HGNCiHGNC:19312 EAPP
HPAiHPA002916
MIMi609486 gene
neXtProtiNX_Q56P03
OpenTargetsiENSG00000129518
PharmGKBiPA162384208
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3395 Eukaryota
ENOG4110B8Q LUCA
GeneTreeiENSGT00390000001332
HOGENOMiHOG000068005
HOVERGENiHBG054593
InParanoidiQ56P03
OMAiKYRTQYR
OrthoDBiEOG091G0BO0
PhylomeDBiQ56P03
TreeFamiTF328497

Enzyme and pathway databases

SIGNORiQ56P03

Miscellaneous databases

ChiTaRSiEAPP human
GeneWikiiEAPP
GenomeRNAii55837
PROiPR:Q56P03
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129518 Expressed in 234 organ(s), highest expression level in kidney
CleanExiHS_EAPP
ExpressionAtlasiQ56P03 baseline and differential
GenevisibleiQ56P03 HS

Family and domain databases

InterProiView protein in InterPro
IPR019370 E2F-assoc_phosphoprotein
PANTHERiPTHR15967 PTHR15967, 1 hit
PfamiView protein in Pfam
PF10238 Eapp_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEAPP_HUMAN
AccessioniPrimary (citable) accession number: Q56P03
Secondary accession number(s): Q9BVF4, Q9NWV5, Q9NZ86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 118 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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