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Protein

N-acetyltransferase ESCO2

Gene

ESCO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri387 – 411CCHH-typeAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • double-strand break repair Source: Ensembl
  • hematopoietic progenitor cell differentiation Source: Ensembl
  • post-translational protein acetylation Source: UniProtKB
  • protein localization to chromatin Source: Ensembl
  • regulation of DNA replication Source: UniProtKB
  • sister chromatid cohesion Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processCell cycle
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2468052 Establishment of Sister Chromatid Cohesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-acetyltransferase ESCO2 (EC:2.3.1.-)
Alternative name(s):
Establishment of cohesion 1 homolog 2
Short name:
ECO1 homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESCO2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000171320.14

Human Gene Nomenclature Database

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HGNCi
HGNC:27230 ESCO2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609353 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q56NI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Roberts syndrome (RBS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive disorder characterized by pre- and postnatal growth retardation, microcephaly, bilateral cleft lip and palate, and mesomelic symmetric limb reduction. Severely affected infants may be stillborn or die shortly after birth. RBS chromosomes have a lack of cohesion involving the heterochromatic C-banding regions around centromeres and the distal portion of the long arm of the Y chromosome (known as premature centromere separation, heterochromatin repulsion or puffing, or RS effect).
See also OMIM:268300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022649539W → G in RBS. 1 PublicationCorresponds to variant dbSNP:rs80359868EnsemblClinVar.1
SC phocomelia syndrome (SCPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionHas a milder phenotype than RBS, with a lesser degree of symmetric limb reduction and additionally includes flexion contractures of various joints, midfacial hemangioma, hypoplastic cartilage of ears and nose, scant silvery-blond hair, and cloudy corneae. Although microcephaly is present, mental retardation may be mild and survival into adulthood is common.
See also OMIM:269000

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
157570

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ESCO2

MalaCards human disease database

More...
MalaCardsi
ESCO2
MIMi268300 phenotype
269000 phenotype

Open Targets

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OpenTargetsi
ENSG00000171320

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3103 Roberts syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134891970

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ESCO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67460434

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000745421 – 601N-acetyltransferase ESCO2Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q56NI9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q56NI9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q56NI9

PeptideAtlas

More...
PeptideAtlasi
Q56NI9

PRoteomics IDEntifications database

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PRIDEi
Q56NI9

ProteomicsDB human proteome resource

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ProteomicsDBi
62581

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q56NI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q56NI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000171320 Expressed in 102 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_ESCO2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q56NI9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q56NI9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027243
HPA053679

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127605, 24 interactors

Protein interaction database and analysis system

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IntActi
Q56NI9, 16 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000306999

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q56NI9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q56NI9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acetyltransferase family. ECO subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri387 – 411CCHH-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3014 Eukaryota
ENOG410XTJX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158598

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000133016

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081482

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q56NI9

KEGG Orthology (KO)

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KOi
K11268

Identification of Orthologs from Complete Genome Data

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OMAi
HCSQQGH

Database of Orthologous Groups

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OrthoDBi
EOG091G0QVI

Database for complete collections of gene phylogenies

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PhylomeDBi
Q56NI9

TreeFam database of animal gene trees

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TreeFami
TF314027

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028005 AcTrfase_ESCO_Znf_dom
IPR028009 ESCO_Acetyltransf_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13880 Acetyltransf_13, 1 hit
PF13878 zf-C2H2_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q56NI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALTPRKRK QDSLKCDSLL HFTENLFPSP NKKHCFYQNS DKNEENLHCS
60 70 80 90 100
QQEHFVLSAL KTTEINRLPS ANQGSPFKSA LSTVSFYNQN KWYLNPLERK
110 120 130 140 150
LIKESRSTCL KTNDEDKSFP IVTEKMQGKP VCSKKNNKKP QKSLTAKYQP
160 170 180 190 200
KYRHIKPVSR NSRNSKQNRV IYKPIVEKEN NCHSAENNSN APRVLSQKIK
210 220 230 240 250
PQVTLQGGAA FFVRKKSSLR KSSLENEPSL GRTQKSKSEV IEDSDVETVS
260 270 280 290 300
EKKTFATRQV PKCLVLEEKL KIGLLSASSK NKEKLIKDSS DDRVSSKEHK
310 320 330 340 350
VDKNEAFSSE DSLGENKTIS PKSTVYPIFS ASSVNSKRSL GEEQFSVGSV
360 370 380 390 400
NFMKQTNIQK NTNTRDTSKK TKDQLIIDAG QKHFGATVCK SCGMIYTASN
410 420 430 440 450
PEDEMQHVQH HHRFLEGIKY VGWKKERVVA EFWDGKIVLV LPHDPSFAIK
460 470 480 490 500
KVEDVQELVD NELGFQQVVP KCPNKIKTFL FISDEKRVVG CLIAEPIKQA
510 520 530 540 550
FRVLSEPIGP ESPSSTECPR AWQCSDVPEP AVCGISRIWV FRLKRRKRIA
560 570 580 590 600
RRLVDTLRNC FMFGCFLSTD EIAFSDPTPD GKLFATKYCN TPNFLVYNFN

S
Length:601
Mass (Da):68,307
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3D10BFD486572AE
GO
Isoform 2 (identifier: Q56NI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-352: Missing.
     581-601: GKLFATKYCNTPNFLVYNFNS → DCRRLNRYQET

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):27,500
Checksum:i054329F214C2BBAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YB88H0YB88_HUMAN
N-acetyltransferase ESCO2
ESCO2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFP7E5RFP7_HUMAN
N-acetyltransferase ESCO2
ESCO2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIE3E5RIE3_HUMAN
N-acetyltransferase ESCO2
ESCO2
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFE4E5RFE4_HUMAN
N-acetyltransferase ESCO2
ESCO2
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03384080A → V. Corresponds to variant dbSNP:rs4732748EnsemblClinVar.1
Natural variantiVAR_060994359Q → P. Corresponds to variant dbSNP:rs57479434EnsemblClinVar.1
Natural variantiVAR_022649539W → G in RBS. 1 PublicationCorresponds to variant dbSNP:rs80359868EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557731 – 352Missing in isoform 2. 1 PublicationAdd BLAST352
Alternative sequenceiVSP_055774581 – 601GKLFA…YNFNS → DCRRLNRYQET in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY882862 mRNA Translation: AAX68677.1
AK124215 mRNA Translation: BAG54021.1
AC104997 Genomic DNA No translation available.
BC034641 mRNA Translation: AAH34641.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34872.1 [Q56NI9-1]

NCBI Reference Sequences

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RefSeqi
NP_001017420.1, NM_001017420.2 [Q56NI9-1]
XP_011542723.1, XM_011544421.2 [Q56NI9-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.99480

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000305188; ENSP00000306999; ENSG00000171320 [Q56NI9-1]
ENST00000397418; ENSP00000380563; ENSG00000171320 [Q56NI9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
157570

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:157570

UCSC genome browser

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UCSCi
uc003xgg.4 human [Q56NI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY882862 mRNA Translation: AAX68677.1
AK124215 mRNA Translation: BAG54021.1
AC104997 Genomic DNA No translation available.
BC034641 mRNA Translation: AAH34641.1
CCDSiCCDS34872.1 [Q56NI9-1]
RefSeqiNP_001017420.1, NM_001017420.2 [Q56NI9-1]
XP_011542723.1, XM_011544421.2 [Q56NI9-1]
UniGeneiHs.99480

3D structure databases

ProteinModelPortaliQ56NI9
SMRiQ56NI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127605, 24 interactors
IntActiQ56NI9, 16 interactors
STRINGi9606.ENSP00000306999

PTM databases

iPTMnetiQ56NI9
PhosphoSitePlusiQ56NI9

Polymorphism and mutation databases

BioMutaiESCO2
DMDMi67460434

Proteomic databases

EPDiQ56NI9
MaxQBiQ56NI9
PaxDbiQ56NI9
PeptideAtlasiQ56NI9
PRIDEiQ56NI9
ProteomicsDBi62581

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
157570
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305188; ENSP00000306999; ENSG00000171320 [Q56NI9-1]
ENST00000397418; ENSP00000380563; ENSG00000171320 [Q56NI9-2]
GeneIDi157570
KEGGihsa:157570
UCSCiuc003xgg.4 human [Q56NI9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
157570
DisGeNETi157570
EuPathDBiHostDB:ENSG00000171320.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ESCO2
GeneReviewsiESCO2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0168881
HGNCiHGNC:27230 ESCO2
HPAiHPA027243
HPA053679
MalaCardsiESCO2
MIMi268300 phenotype
269000 phenotype
609353 gene
neXtProtiNX_Q56NI9
OpenTargetsiENSG00000171320
Orphaneti3103 Roberts syndrome
PharmGKBiPA134891970

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3014 Eukaryota
ENOG410XTJX LUCA
GeneTreeiENSGT00940000158598
HOGENOMiHOG000133016
HOVERGENiHBG081482
InParanoidiQ56NI9
KOiK11268
OMAiHCSQQGH
OrthoDBiEOG091G0QVI
PhylomeDBiQ56NI9
TreeFamiTF314027

Enzyme and pathway databases

ReactomeiR-HSA-2468052 Establishment of Sister Chromatid Cohesion

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ESCO2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ESCO2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
157570

Protein Ontology

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PROi
PR:Q56NI9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000171320 Expressed in 102 organ(s), highest expression level in oocyte
CleanExiHS_ESCO2
ExpressionAtlasiQ56NI9 baseline and differential
GenevisibleiQ56NI9 HS

Family and domain databases

InterProiView protein in InterPro
IPR028005 AcTrfase_ESCO_Znf_dom
IPR028009 ESCO_Acetyltransf_dom
PfamiView protein in Pfam
PF13880 Acetyltransf_13, 1 hit
PF13878 zf-C2H2_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESCO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q56NI9
Secondary accession number(s): B3KW59, Q49AP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 10, 2005
Last modified: December 5, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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