UniProtKB - Q56A73 (SPIN4_HUMAN)

BLAST

>sp|Q56A73|SPIN4_HUMAN Spindlin-4 OS=Homo sapiens OX=9606 GN=SPIN4 PE=1 SV=1
MSPPTVPPMGVDGVSAYLMKKRHTHRKQRRKPTFLTRRNIVGCRIQHGWKEGNEPVEQWK
GTVLEQVSVKPTLYIIKYDGKDSVYGLELHRDKRVLALEILPERVPTPRIDSRLADSLIG
KAVEHVFEGEHGTKDEWKGMVLARAPVMDTWFYITYEKDPVLYMYTLLDDYKDGDLRIIP
DSNYYFPTAEQEPGEVVDSLVGKQVEHAKDDGSKRTGIFIHQVVAKPSVYFIKFDDDIHI
YVYGLVKTP

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History
Entry version 100 (07 Nov 2018)
Sequence version 1 (10 May 2005)
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Protein

Spindlin-4

Gene

SPIN4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Exhibits H3K4me3-binding activity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	159	Histone H3K4me3 and H3R8me2aBy similarity		1
Binding siteⁱ	170	Histone H3K4me3 and H3R8me2aBy similarity		1

GO - Molecular functionⁱ

methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 29061846

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gamete generation Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spindlin-4
Gene namesⁱ	Name:SPIN4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186767.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27040 SPIN4
neXtProtⁱ	NX_Q56A73

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000186767
PharmGKBⁱ	PA162404539

Polymorphism and mutation databases

BioMutaⁱ	SPIN4
DMDMⁱ	74735974

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000313794	1 – 249	Spindlin-4Add BLAST		249

Proteomic databases

EPDⁱ	Q56A73
PaxDbⁱ	Q56A73
PeptideAtlas More...PeptideAtlasⁱ	Q56A73
PRIDEⁱ	Q56A73
ProteomicsDBⁱ	62580

PTM databases

iPTMnetⁱ	Q56A73
PhosphoSitePlusⁱ	Q56A73

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186767 Expressed in 182 organ(s), highest expression level in metanephros
CleanExⁱ	HS_SPIN4
ExpressionAtlasⁱ	Q56A73 baseline and differential
Genevisibleⁱ	Q56A73 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044559

HPAⁱ

HPA044559

Interactionⁱ

Subunit structureⁱ

Interacts with C11orf84/SPINDOC (PubMed:29061846).1 Publication

GO - Molecular functionⁱ

methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 29061846

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	126590, 6 interactors

BioGridⁱ

126590, 6 interactors

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	44 – 49	Combined sources	6
Beta strandⁱ	57 – 66	Combined sources	10
Beta strandⁱ	74 – 78	Combined sources	5
Beta strandⁱ	85 – 87	Combined sources	3
Turnⁱ	89 – 91	Combined sources	3
Beta strandⁱ	95 – 101	Combined sources	7
Helixⁱ	112 – 118	Combined sources	7
Beta strandⁱ	122 – 127	Combined sources	6
Turnⁱ	130 – 132	Combined sources	3
Beta strandⁱ	135 – 144	Combined sources	10
Beta strandⁱ	146 – 148	Combined sources	3
Beta strandⁱ	151 – 156	Combined sources	6
Beta strandⁱ	159 – 165	Combined sources	7
Helixⁱ	168 – 172	Combined sources	5
Beta strandⁱ	176 – 181	Combined sources	6
Beta strandⁱ	204 – 208	Combined sources	5
Beta strandⁱ	214 – 222	Combined sources	9
Beta strandⁱ	224 – 226	Combined sources	3
Beta strandⁱ	229 – 234	Combined sources	6
Beta strandⁱ	241 – 245	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q56A73
SMRⁱ	Q56A73
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	41 – 90	Tudor-like domain 1Sequence analysisAdd BLAST	50
Regionⁱ	119 – 168	Tudor-like domain 2Sequence analysisAdd BLAST	50
Regionⁱ	128	Histone H3K4me3 and H3R8me2a bindingBy similarity	1
Regionⁱ	201 – 246	Tudor-like domain 3Sequence analysisAdd BLAST	46
Regionⁱ	237 – 239	Histone H3K4me3 and H3R8me2a bindingBy similarity	3

Sequence similaritiesⁱ

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410JB46 Eukaryota ENOG41113VC LUCA
HOGENOMⁱ	HOG000293367
HOVERGENⁱ	HBG000686
InParanoidⁱ	Q56A73
OMAⁱ	HGKKDEW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EE3
PhylomeDBⁱ	Q56A73
TreeFamⁱ	TF332665

Family and domain databases

InterProⁱ	View protein in InterPro IPR003671 SPIN/Ssty IPR029578 Spindlin-4
PANTHERⁱ	PTHR10405 PTHR10405, 1 hit PTHR10405:SF9 PTHR10405:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02513 Spin-Ssty, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q56A73-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSPPTVPPMG VDGVSAYLMK KRHTHRKQRR KPTFLTRRNI VGCRIQHGWK 
        60         70         80         90        100
EGNEPVEQWK GTVLEQVSVK PTLYIIKYDG KDSVYGLELH RDKRVLALEI 
       110        120        130        140        150
LPERVPTPRI DSRLADSLIG KAVEHVFEGE HGTKDEWKGM VLARAPVMDT 
       160        170        180        190        200
WFYITYEKDP VLYMYTLLDD YKDGDLRIIP DSNYYFPTAE QEPGEVVDSL 
       210        220        230        240 
VGKQVEHAKD DGSKRTGIFI HQVVAKPSVY FIKFDDDIHI YVYGLVKTP

Length:249

Mass (Da):28,660

Last modified:May 10, 2005 - v1

Checksum:ⁱFF0CB0229107D8D4

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X6R8Y7	X6R8Y7_HUMAN		Spindlin-4 Spindlin-4	SPIN4	249	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	227	P → S in BAG54402 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK126931 mRNA Translation: BAG54402.1 AL158203 Genomic DNA No translation available. BC043412 mRNA Translation: AAH43412.1 BC112360 mRNA Translation: AAI12361.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43964.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001012986.2, NM_001012968.2
UniGeneⁱ	Hs.612782

Genome annotation databases

Ensemblⁱ	ENST00000374884; ENSP00000364018; ENSG00000186767
GeneIDⁱ	139886
KEGGⁱ	hsa:139886
UCSC genome browser More...UCSCⁱ	uc004dvf.3 human

Protein	Similar proteins		Species	Score	Length	Source
Q56A73	Spindlin-4		HUMAN		249	UniRef100_Q56A73
SPIN4 isoform 1		PANTR		249
SPIN4 isoform 1		PONAB		249
Uncharacterized protein		PANPA		249
Uncharacterized protein		NOMLE		249
+1

Protein	Similar proteins		Species	Score	Length	Source
Q56A73	Spindlin-4		MOUSE		249	UniRef90_Q56A73
Spindlin-4		HUMAN		249
SPIN4 isoform 1		PANTR		249
SPIN4 isoform 1		PONAB		249
Uncharacterized protein		PANPA		249
+90

Protein	Similar proteins		Species	Score	Length	Source
Q56A73	Isoform 2 of Spindlin-1		MOUSE		240	UniRef50_Q61142-2
Spindlin-3		PONAB		258
Spindlin-3	)	HUMAN		258
Spin protein		XENTR		262
Uncharacterized protein		LATCH		262
+240

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK126931 mRNA Translation: BAG54402.1 AL158203 Genomic DNA No translation available. BC043412 mRNA Translation: AAH43412.1 BC112360 mRNA Translation: AAI12361.1
CCDSⁱ	CCDS43964.1
RefSeqⁱ	NP_001012986.2, NM_001012968.2
UniGeneⁱ	Hs.612782

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4UY4	X-ray	1.86	A/B	36-249	[»]
ProteinModelPortalⁱ	Q56A73
SMRⁱ	Q56A73
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126590, 6 interactors

BioGridⁱ

126590, 6 interactors

PTM databases

iPTMnetⁱ	Q56A73
PhosphoSitePlusⁱ	Q56A73

Polymorphism and mutation databases

BioMutaⁱ	SPIN4
DMDMⁱ	74735974

Proteomic databases

EPDⁱ	Q56A73
PaxDbⁱ	Q56A73
PeptideAtlasⁱ	Q56A73
PRIDEⁱ	Q56A73
ProteomicsDBⁱ	62580

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000374884; ENSP00000364018; ENSG00000186767
GeneIDⁱ	139886
KEGGⁱ	hsa:139886
UCSCⁱ	uc004dvf.3 human

Organism-specific databases

CTDⁱ	139886
EuPathDBⁱ	HostDB:ENSG00000186767.5
GeneCardsⁱ	SPIN4
HGNCⁱ	HGNC:27040 SPIN4
HPAⁱ	HPA044559
neXtProtⁱ	NX_Q56A73
OpenTargetsⁱ	ENSG00000186767
PharmGKBⁱ	PA162404539
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JB46 Eukaryota ENOG41113VC LUCA
HOGENOMⁱ	HOG000293367
HOVERGENⁱ	HBG000686
InParanoidⁱ	Q56A73
OMAⁱ	HGKKDEW
OrthoDBⁱ	EOG091G0EE3
PhylomeDBⁱ	Q56A73
TreeFamⁱ	TF332665

Miscellaneous databases

GenomeRNAiⁱ	139886
Protein Ontology More...PROⁱ	PR:Q56A73

Gene expression databases

Bgeeⁱ	ENSG00000186767 Expressed in 182 organ(s), highest expression level in metanephros
CleanExⁱ	HS_SPIN4
ExpressionAtlasⁱ	Q56A73 baseline and differential
Genevisibleⁱ	Q56A73 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003671 SPIN/Ssty IPR029578 Spindlin-4
PANTHERⁱ	PTHR10405 PTHR10405, 1 hit PTHR10405:SF9 PTHR10405:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF02513 Spin-Ssty, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPIN4_HUMAN
Accessionⁱ	Q56A73Primary (citable) accession number: Q56A73 Secondary accession number(s): B3KX90, Q5JUL2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	May 10, 2005
	Last modified:	November 7, 2018
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q56A73 (SPIN4_HUMAN)

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Spindlin-4

SPIN4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ