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UniProtKB - Q56A73 (SPIN4_HUMAN)
Protein
Spindlin-4
Gene
SPIN4
Organism
Homo sapiens (Human)
Status
Functioni
Exhibits H3K4me3-binding activity.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 159 | Histone H3K4me3 and H3R8me2a bindingBy similarity | 1 | |
Sitei | 170 | Histone H3K4me3 and H3R8me2a bindingBy similarity | 1 |
GO - Molecular functioni
- methylated histone binding Source: UniProtKB
GO - Biological processi
- gamete generation Source: InterPro
- regulation of transcription, DNA-templated Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q56A73 |
SignaLinki | Q56A73 |
Names & Taxonomyi
Protein namesi | Recommended name: Spindlin-4 |
Gene namesi | Name:SPIN4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27040, SPIN4 |
neXtProti | NX_Q56A73 |
VEuPathDBi | HostDB:ENSG00000186767 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000186767 |
PharmGKBi | PA162404539 |
Miscellaneous databases
Pharosi | Q56A73, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4523321 |
Genetic variation databases
BioMutai | SPIN4 |
DMDMi | 74735974 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313794 | 1 – 249 | Spindlin-4Add BLAST | 249 |
Proteomic databases
EPDi | Q56A73 |
MassIVEi | Q56A73 |
PaxDbi | Q56A73 |
PeptideAtlasi | Q56A73 |
PRIDEi | Q56A73 |
ProteomicsDBi | 62580 |
PTM databases
GlyGeni | Q56A73, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q56A73 |
PhosphoSitePlusi | Q56A73 |
Expressioni
Gene expression databases
Bgeei | ENSG00000186767, Expressed in metanephros and 198 other tissues |
ExpressionAtlasi | Q56A73, baseline and differential |
Genevisiblei | Q56A73, HS |
Organism-specific databases
HPAi | ENSG00000186767, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with C11orf84/SPINDOC (PubMed:29061846).
1 PublicationGO - Molecular functioni
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 126590, 13 interactors |
IntActi | Q56A73, 1 interactor |
STRINGi | 9606.ENSP00000334163 |
Chemistry databases
BindingDBi | Q56A73 |
Miscellaneous databases
RNActi | Q56A73, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q56A73 |
SMRi | Q56A73 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 90 | Tudor-like domain 1Sequence analysisAdd BLAST | 50 | |
Regioni | 119 – 168 | Tudor-like domain 2Sequence analysisAdd BLAST | 50 | |
Regioni | 128 | Histone H3K4me3 and H3R8me2a bindingBy similarity | 1 | |
Regioni | 201 – 246 | Tudor-like domain 3Sequence analysisAdd BLAST | 46 | |
Regioni | 237 – 239 | Histone H3K4me3 and H3R8me2a bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the SPIN/STSY family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRYD, Eukaryota |
GeneTreei | ENSGT00950000182925 |
InParanoidi | Q56A73 |
OMAi | HGRKDEW |
OrthoDBi | 1027563at2759 |
PhylomeDBi | Q56A73 |
TreeFami | TF332665 |
Family and domain databases
Gene3Di | 2.80.10.70, 1 hit |
InterProi | View protein in InterPro IPR003671, SPIN/Ssty IPR042567, SPIN/Ssty_sf IPR029578, Spindlin-4 |
PANTHERi | PTHR10405, PTHR10405, 1 hit PTHR10405:SF9, PTHR10405:SF9, 1 hit |
Pfami | View protein in Pfam PF02513, Spin-Ssty, 3 hits |
i Sequence
Sequence statusi: Complete.
Q56A73-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPPTVPPMG VDGVSAYLMK KRHTHRKQRR KPTFLTRRNI VGCRIQHGWK
60 70 80 90 100
EGNEPVEQWK GTVLEQVSVK PTLYIIKYDG KDSVYGLELH RDKRVLALEI
110 120 130 140 150
LPERVPTPRI DSRLADSLIG KAVEHVFEGE HGTKDEWKGM VLARAPVMDT
160 170 180 190 200
WFYITYEKDP VLYMYTLLDD YKDGDLRIIP DSNYYFPTAE QEPGEVVDSL
210 220 230 240
VGKQVEHAKD DGSKRTGIFI HQVVAKPSVY FIKFDDDIHI YVYGLVKTP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 227 | P → S in BAG54402 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126931 mRNA Translation: BAG54402.1 AL158203 Genomic DNA No translation available. BC043412 mRNA Translation: AAH43412.1 BC112360 mRNA Translation: AAI12361.1 |
CCDSi | CCDS43964.1 |
RefSeqi | NP_001012986.2, NM_001012968.2 |
Genome annotation databases
Ensembli | ENST00000374884.3; ENSP00000364018.3; ENSG00000186767.7 |
GeneIDi | 139886 |
KEGGi | hsa:139886 |
MANE-Selecti | ENST00000374884.3; ENSP00000364018.3; NM_001012968.3; NP_001012986.2 |
UCSCi | uc004dvf.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126931 mRNA Translation: BAG54402.1 AL158203 Genomic DNA No translation available. BC043412 mRNA Translation: AAH43412.1 BC112360 mRNA Translation: AAI12361.1 |
CCDSi | CCDS43964.1 |
RefSeqi | NP_001012986.2, NM_001012968.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UY4 | X-ray | 1.86 | A/B | 36-249 | [»] | |
AlphaFoldDBi | Q56A73 | |||||
SMRi | Q56A73 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126590, 13 interactors |
IntActi | Q56A73, 1 interactor |
STRINGi | 9606.ENSP00000334163 |
Chemistry databases
BindingDBi | Q56A73 |
ChEMBLi | CHEMBL4523321 |
PTM databases
GlyGeni | Q56A73, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q56A73 |
PhosphoSitePlusi | Q56A73 |
Genetic variation databases
BioMutai | SPIN4 |
DMDMi | 74735974 |
Proteomic databases
EPDi | Q56A73 |
MassIVEi | Q56A73 |
PaxDbi | Q56A73 |
PeptideAtlasi | Q56A73 |
PRIDEi | Q56A73 |
ProteomicsDBi | 62580 |
Protocols and materials databases
Antibodypediai | 52266, 78 antibodies from 13 providers |
DNASUi | 139886 |
Genome annotation databases
Ensembli | ENST00000374884.3; ENSP00000364018.3; ENSG00000186767.7 |
GeneIDi | 139886 |
KEGGi | hsa:139886 |
MANE-Selecti | ENST00000374884.3; ENSP00000364018.3; NM_001012968.3; NP_001012986.2 |
UCSCi | uc004dvf.3, human |
Organism-specific databases
CTDi | 139886 |
GeneCardsi | SPIN4 |
HGNCi | HGNC:27040, SPIN4 |
HPAi | ENSG00000186767, Low tissue specificity |
neXtProti | NX_Q56A73 |
OpenTargetsi | ENSG00000186767 |
PharmGKBi | PA162404539 |
VEuPathDBi | HostDB:ENSG00000186767 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRYD, Eukaryota |
GeneTreei | ENSGT00950000182925 |
InParanoidi | Q56A73 |
OMAi | HGRKDEW |
OrthoDBi | 1027563at2759 |
PhylomeDBi | Q56A73 |
TreeFami | TF332665 |
Enzyme and pathway databases
PathwayCommonsi | Q56A73 |
SignaLinki | Q56A73 |
Miscellaneous databases
BioGRID-ORCSi | 139886, 13 hits in 675 CRISPR screens |
ChiTaRSi | SPIN4, human |
GenomeRNAii | 139886 |
Pharosi | Q56A73, Tchem |
PROi | PR:Q56A73 |
RNActi | Q56A73, protein |
Gene expression databases
Bgeei | ENSG00000186767, Expressed in metanephros and 198 other tissues |
ExpressionAtlasi | Q56A73, baseline and differential |
Genevisiblei | Q56A73, HS |
Family and domain databases
Gene3Di | 2.80.10.70, 1 hit |
InterProi | View protein in InterPro IPR003671, SPIN/Ssty IPR042567, SPIN/Ssty_sf IPR029578, Spindlin-4 |
PANTHERi | PTHR10405, PTHR10405, 1 hit PTHR10405:SF9, PTHR10405:SF9, 1 hit |
Pfami | View protein in Pfam PF02513, Spin-Ssty, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SPIN4_HUMAN | |
Accessioni | Q56A73Primary (citable) accession number: Q56A73 Secondary accession number(s): B3KX90, Q5JUL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families