Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spindlin-4

Gene

SPIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits H3K4me3-binding activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159Histone H3K4me3 and H3R8me2aBy similarity1
Binding sitei170Histone H3K4me3 and H3R8me2aBy similarity1

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Spindlin-4
Gene namesi
Name:SPIN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000186767.5
HGNCiHGNC:27040 SPIN4
neXtProtiNX_Q56A73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186767
PharmGKBiPA162404539

Polymorphism and mutation databases

BioMutaiSPIN4
DMDMi74735974

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137941 – 249Spindlin-4Add BLAST249

Proteomic databases

EPDiQ56A73
PaxDbiQ56A73
PeptideAtlasiQ56A73
PRIDEiQ56A73
ProteomicsDBi62580

PTM databases

iPTMnetiQ56A73
PhosphoSitePlusiQ56A73

Expressioni

Gene expression databases

BgeeiENSG00000186767 Expressed in 182 organ(s), highest expression level in metanephros
CleanExiHS_SPIN4
ExpressionAtlasiQ56A73 baseline and differential
GenevisibleiQ56A73 HS

Organism-specific databases

HPAiHPA044559

Interactioni

Subunit structurei

Interacts with C11orf84/SPINDOC (PubMed:29061846).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126590, 6 interactors

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ56A73
SMRiQ56A73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 90Tudor-like domain 1Sequence analysisAdd BLAST50
Regioni119 – 168Tudor-like domain 2Sequence analysisAdd BLAST50
Regioni128Histone H3K4me3 and H3R8me2a bindingBy similarity1
Regioni201 – 246Tudor-like domain 3Sequence analysisAdd BLAST46
Regioni237 – 239Histone H3K4me3 and H3R8me2a bindingBy similarity3

Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGiENOG410JB46 Eukaryota
ENOG41113VC LUCA
HOGENOMiHOG000293367
HOVERGENiHBG000686
InParanoidiQ56A73
OMAiHGKKDEW
OrthoDBiEOG091G0EE3
PhylomeDBiQ56A73
TreeFamiTF332665

Family and domain databases

InterProiView protein in InterPro
IPR003671 SPIN/Ssty
IPR029578 Spindlin-4
PANTHERiPTHR10405 PTHR10405, 1 hit
PTHR10405:SF9 PTHR10405:SF9, 1 hit
PfamiView protein in Pfam
PF02513 Spin-Ssty, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q56A73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPPTVPPMG VDGVSAYLMK KRHTHRKQRR KPTFLTRRNI VGCRIQHGWK
60 70 80 90 100
EGNEPVEQWK GTVLEQVSVK PTLYIIKYDG KDSVYGLELH RDKRVLALEI
110 120 130 140 150
LPERVPTPRI DSRLADSLIG KAVEHVFEGE HGTKDEWKGM VLARAPVMDT
160 170 180 190 200
WFYITYEKDP VLYMYTLLDD YKDGDLRIIP DSNYYFPTAE QEPGEVVDSL
210 220 230 240
VGKQVEHAKD DGSKRTGIFI HQVVAKPSVY FIKFDDDIHI YVYGLVKTP
Length:249
Mass (Da):28,660
Last modified:May 10, 2005 - v1
Checksum:iFF0CB0229107D8D4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R8Y7X6R8Y7_HUMAN
Spindlin-4
SPIN4
249Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227P → S in BAG54402 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126931 mRNA Translation: BAG54402.1
AL158203 Genomic DNA No translation available.
BC043412 mRNA Translation: AAH43412.1
BC112360 mRNA Translation: AAI12361.1
CCDSiCCDS43964.1
RefSeqiNP_001012986.2, NM_001012968.2
UniGeneiHs.612782

Genome annotation databases

EnsembliENST00000374884; ENSP00000364018; ENSG00000186767
GeneIDi139886
KEGGihsa:139886
UCSCiuc004dvf.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126931 mRNA Translation: BAG54402.1
AL158203 Genomic DNA No translation available.
BC043412 mRNA Translation: AAH43412.1
BC112360 mRNA Translation: AAI12361.1
CCDSiCCDS43964.1
RefSeqiNP_001012986.2, NM_001012968.2
UniGeneiHs.612782

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UY4X-ray1.86A/B36-249[»]
ProteinModelPortaliQ56A73
SMRiQ56A73
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126590, 6 interactors

PTM databases

iPTMnetiQ56A73
PhosphoSitePlusiQ56A73

Polymorphism and mutation databases

BioMutaiSPIN4
DMDMi74735974

Proteomic databases

EPDiQ56A73
PaxDbiQ56A73
PeptideAtlasiQ56A73
PRIDEiQ56A73
ProteomicsDBi62580

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374884; ENSP00000364018; ENSG00000186767
GeneIDi139886
KEGGihsa:139886
UCSCiuc004dvf.3 human

Organism-specific databases

CTDi139886
EuPathDBiHostDB:ENSG00000186767.5
GeneCardsiSPIN4
HGNCiHGNC:27040 SPIN4
HPAiHPA044559
neXtProtiNX_Q56A73
OpenTargetsiENSG00000186767
PharmGKBiPA162404539
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB46 Eukaryota
ENOG41113VC LUCA
HOGENOMiHOG000293367
HOVERGENiHBG000686
InParanoidiQ56A73
OMAiHGKKDEW
OrthoDBiEOG091G0EE3
PhylomeDBiQ56A73
TreeFamiTF332665

Miscellaneous databases

GenomeRNAii139886
PROiPR:Q56A73

Gene expression databases

BgeeiENSG00000186767 Expressed in 182 organ(s), highest expression level in metanephros
CleanExiHS_SPIN4
ExpressionAtlasiQ56A73 baseline and differential
GenevisibleiQ56A73 HS

Family and domain databases

InterProiView protein in InterPro
IPR003671 SPIN/Ssty
IPR029578 Spindlin-4
PANTHERiPTHR10405 PTHR10405, 1 hit
PTHR10405:SF9 PTHR10405:SF9, 1 hit
PfamiView protein in Pfam
PF02513 Spin-Ssty, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSPIN4_HUMAN
AccessioniPrimary (citable) accession number: Q56A73
Secondary accession number(s): B3KX90, Q5JUL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again