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UniProtKB - Q56A73 (SPIN4_HUMAN)

Entry version 119 (25 May 2022)
Sequence version 1 (10 May 2005)
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Protein

Spindlin-4

Gene

SPIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits H3K4me3-binding activity.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei159Histone H3K4me3 and H3R8me2a bindingBy similarity1
Sitei170Histone H3K4me3 and H3R8me2a bindingBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q56A73

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q56A73

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spindlin-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPIN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27040, SPIN4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q56A73

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186767

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000186767

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162404539

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q56A73, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523321

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPIN4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74735974

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003137941 – 249Spindlin-4Add BLAST249

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q56A73

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q56A73

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q56A73

PeptideAtlas

More...PeptideAtlasi		Q56A73

PRoteomics IDEntifications database

More...PRIDEi		Q56A73

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62580

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q56A73, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q56A73

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q56A73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186767, Expressed in metanephros and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q56A73, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q56A73, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186767, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with C11orf84/SPINDOC (PubMed:29061846).

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126590, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q56A73, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000334163

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q56A73

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q56A73, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q56A73

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q56A73

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 90Tudor-like domain 1Sequence analysisAdd BLAST50
Regioni119 – 168Tudor-like domain 2Sequence analysisAdd BLAST50
Regioni128Histone H3K4me3 and H3R8me2a bindingBy similarity1
Regioni201 – 246Tudor-like domain 3Sequence analysisAdd BLAST46
Regioni237 – 239Histone H3K4me3 and H3R8me2a bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRYD, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182925

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q56A73

Identification of Orthologs from Complete Genome Data

More...OMAi		HGRKDEW

Database of Orthologous Groups

More...OrthoDBi		1027563at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q56A73

TreeFam database of animal gene trees

More...TreeFami		TF332665

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.80.10.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003671, SPIN/Ssty
IPR042567, SPIN/Ssty_sf
IPR029578, Spindlin-4

The PANTHER Classification System

More...PANTHERi		PTHR10405, PTHR10405, 1 hit
PTHR10405:SF9, PTHR10405:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02513, Spin-Ssty, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q56A73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPPTVPPMG VDGVSAYLMK KRHTHRKQRR KPTFLTRRNI VGCRIQHGWK 
        60         70         80         90        100
EGNEPVEQWK GTVLEQVSVK PTLYIIKYDG KDSVYGLELH RDKRVLALEI 
       110        120        130        140        150
LPERVPTPRI DSRLADSLIG KAVEHVFEGE HGTKDEWKGM VLARAPVMDT 
       160        170        180        190        200
WFYITYEKDP VLYMYTLLDD YKDGDLRIIP DSNYYFPTAE QEPGEVVDSL 
       210        220        230        240 
VGKQVEHAKD DGSKRTGIFI HQVVAKPSVY FIKFDDDIHI YVYGLVKTP
Length:249
Mass (Da):28,660
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF0CB0229107D8D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227P → S in BAG54402 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK126931 mRNA Translation: BAG54402.1
AL158203 Genomic DNA No translation available.
BC043412 mRNA Translation: AAH43412.1
BC112360 mRNA Translation: AAI12361.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43964.1

NCBI Reference Sequences

More...RefSeqi		NP_001012986.2, NM_001012968.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374884.3; ENSP00000364018.3; ENSG00000186767.7

Database of genes from NCBI RefSeq genomes

More...GeneIDi		139886

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:139886

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000374884.3; ENSP00000364018.3; NM_001012968.3; NP_001012986.2

UCSC genome browser

More...UCSCi		uc004dvf.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126931 mRNA Translation: BAG54402.1
AL158203 Genomic DNA No translation available.
BC043412 mRNA Translation: AAH43412.1
BC112360 mRNA Translation: AAI12361.1
CCDSiCCDS43964.1
RefSeqiNP_001012986.2, NM_001012968.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UY4X-ray1.86A/B36-249[»]
AlphaFoldDBiQ56A73
SMRiQ56A73
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi126590, 13 interactors
IntActiQ56A73, 1 interactor
STRINGi9606.ENSP00000334163

Chemistry databases

BindingDBiQ56A73
ChEMBLiCHEMBL4523321

PTM databases

GlyGeniQ56A73, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ56A73
PhosphoSitePlusiQ56A73

Genetic variation databases

BioMutaiSPIN4
DMDMi74735974

Proteomic databases

EPDiQ56A73
MassIVEiQ56A73
PaxDbiQ56A73
PeptideAtlasiQ56A73
PRIDEiQ56A73
ProteomicsDBi62580

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52266, 78 antibodies from 13 providers

The DNASU plasmid repository

More...DNASUi		139886

Genome annotation databases

EnsembliENST00000374884.3; ENSP00000364018.3; ENSG00000186767.7
GeneIDi139886
KEGGihsa:139886
MANE-SelectiENST00000374884.3; ENSP00000364018.3; NM_001012968.3; NP_001012986.2
UCSCiuc004dvf.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		139886

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPIN4
HGNCiHGNC:27040, SPIN4
HPAiENSG00000186767, Low tissue specificity
neXtProtiNX_Q56A73
OpenTargetsiENSG00000186767
PharmGKBiPA162404539
VEuPathDBiHostDB:ENSG00000186767

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRYD, Eukaryota
GeneTreeiENSGT00950000182925
InParanoidiQ56A73
OMAiHGRKDEW
OrthoDBi1027563at2759
PhylomeDBiQ56A73
TreeFamiTF332665

Enzyme and pathway databases

PathwayCommonsiQ56A73
SignaLinkiQ56A73

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		139886, 13 hits in 675 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPIN4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		139886
PharosiQ56A73, Tchem

Protein Ontology

More...PROi		PR:Q56A73
RNActiQ56A73, protein

Gene expression databases

BgeeiENSG00000186767, Expressed in metanephros and 198 other tissues
ExpressionAtlasiQ56A73, baseline and differential
GenevisibleiQ56A73, HS

Family and domain databases

Gene3Di2.80.10.70, 1 hit
InterProiView protein in InterPro
IPR003671, SPIN/Ssty
IPR042567, SPIN/Ssty_sf
IPR029578, Spindlin-4
PANTHERiPTHR10405, PTHR10405, 1 hit
PTHR10405:SF9, PTHR10405:SF9, 1 hit
PfamiView protein in Pfam
PF02513, Spin-Ssty, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIN4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q56A73
Secondary accession number(s): B3KX90, Q5JUL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: May 25, 2022
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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