UniProtKB - Q56A07 (SCN2B_MOUSE)
Protein
Sodium channel subunit beta-2
Gene
Scn2b
Organism
Mus musculus (Mouse)
Status
Functioni
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 56 | Binds SCN2ABy similarity | 1 | |
Sitei | 135 | Binds SCN2ABy similarity | 1 |
GO - Molecular functioni
- sodium channel regulator activity Source: MGI
- voltage-gated ion channel activity Source: UniProtKB-KW
- voltage-gated sodium channel activity Source: MGI
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: MGI
GO - Biological processi
- cardiac muscle cell action potential involved in contraction Source: MGI
- cardiac muscle contraction Source: MGI
- membrane depolarization during cardiac muscle cell action potential Source: MGI
- nervous system development Source: Ensembl
- regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
- regulation of heart rate by cardiac conduction Source: MGI
- regulation of sodium ion transmembrane transporter activity Source: MGI
- response to pyrethroid Source: MGI
- sodium ion transmembrane transport Source: MGI
Keywordsi
Molecular function | Ion channel, Sodium channel, Voltage-gated channel |
Biological process | Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-5576892, Phase 0 - rapid depolarisation |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel subunit beta-2 |
Gene namesi | Name:Scn2b Synonyms:Gm183 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106921, Scn2b |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- voltage-gated sodium channel complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 159 | ExtracellularSequence analysisAdd BLAST | 130 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 181 – 215 | CytoplasmicSequence analysisAdd BLAST | 35 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | By similarityAdd BLAST | 29 | |
ChainiPRO_0000045177 | 30 – 215 | Sodium channel subunit beta-2Add BLAST | 186 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 42 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 50 ↔ 127 | PROSITE-ProRule annotationBy similarity | ||
Disulfide bondi | 55 | Interchain; with alpha subunitPROSITE-ProRule annotationBy similarity | ||
Glycosylationi | 66 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 72 ↔ 75 | By similarity | ||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 192 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q56A07 |
PaxDbi | Q56A07 |
PRIDEi | Q56A07 |
PTM databases
GlyGeni | Q56A07, 3 sites |
iPTMneti | Q56A07 |
PhosphoSitePlusi | Q56A07 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000070304, Expressed in visual cortex and 222 other tissues |
ExpressionAtlasi | Q56A07, baseline and differential |
Genevisiblei | Q56A07, MM |
Interactioni
Subunit structurei
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit (SCN2A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B). SCN1B and SCN3B are non-covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked to SCN2A (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000126826 |
Miscellaneous databases
RNActi | Q56A07, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 154 | Ig-like C2-typeAdd BLAST | 123 |
Sequence similaritiesi
Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family. [View classification]Curated
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R29H, Eukaryota |
GeneTreei | ENSGT01000000214451 |
HOGENOMi | CLU_090350_0_0_1 |
InParanoidi | Q56A07 |
OMAi | TNPPDRH |
OrthoDBi | 1380581at2759 |
PhylomeDBi | Q56A07 |
TreeFami | TF331728 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000920, Myelin_P0-rel IPR029873, SCN2B |
PANTHERi | PTHR13869, PTHR13869, 1 hit PTHR13869:SF3, PTHR13869:SF3, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
PRINTSi | PR00213, MYELINP0 |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q56A07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTAPTTLSV LNGSDTRLPC
60 70 80 90 100
TFNSCYTVNH KQFSLNWTYQ ECNNCTEEMF LQFRMKIINL KLERFGDRVE
110 120 130 140 150
FSGNPSKYDV SVTLKNVQLE DEGIYNCYIT NPPDRHRGHG KIYLQVLLEV
160 170 180 190 200
PPERDSTVAV IVGASVGGFL AVVILVLMVV KCVRRKKEQK LSTDDLKTEE
210
EGKMDGEGNA EDGTK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC092225 mRNA Translation: AAH92225.1 |
CCDSi | CCDS40606.1 |
RefSeqi | NP_001014761.1, NM_001014761.2 |
Genome annotation databases
Ensembli | ENSMUST00000093855; ENSMUSP00000091377; ENSMUSG00000070304 ENSMUST00000170998; ENSMUSP00000126826; ENSMUSG00000070304 |
GeneIDi | 72821 |
KEGGi | mmu:72821 |
UCSCi | uc009pfg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC092225 mRNA Translation: AAH92225.1 |
CCDSi | CCDS40606.1 |
RefSeqi | NP_001014761.1, NM_001014761.2 |
3D structure databases
SMRi | Q56A07 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000126826 |
PTM databases
GlyGeni | Q56A07, 3 sites |
iPTMneti | Q56A07 |
PhosphoSitePlusi | Q56A07 |
Proteomic databases
MaxQBi | Q56A07 |
PaxDbi | Q56A07 |
PRIDEi | Q56A07 |
Protocols and materials databases
ABCDi | Q56A07, 1 sequenced antibody |
Antibodypediai | 2511, 288 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000093855; ENSMUSP00000091377; ENSMUSG00000070304 ENSMUST00000170998; ENSMUSP00000126826; ENSMUSG00000070304 |
GeneIDi | 72821 |
KEGGi | mmu:72821 |
UCSCi | uc009pfg.1, mouse |
Organism-specific databases
CTDi | 6327 |
MGIi | MGI:106921, Scn2b |
Phylogenomic databases
eggNOGi | ENOG502R29H, Eukaryota |
GeneTreei | ENSGT01000000214451 |
HOGENOMi | CLU_090350_0_0_1 |
InParanoidi | Q56A07 |
OMAi | TNPPDRH |
OrthoDBi | 1380581at2759 |
PhylomeDBi | Q56A07 |
TreeFami | TF331728 |
Enzyme and pathway databases
Reactomei | R-MMU-5576892, Phase 0 - rapid depolarisation |
Miscellaneous databases
BioGRID-ORCSi | 72821, 2 hits in 17 CRISPR screens |
PROi | PR:Q56A07 |
RNActi | Q56A07, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000070304, Expressed in visual cortex and 222 other tissues |
ExpressionAtlasi | Q56A07, baseline and differential |
Genevisiblei | Q56A07, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000920, Myelin_P0-rel IPR029873, SCN2B |
PANTHERi | PTHR13869, PTHR13869, 1 hit PTHR13869:SF3, PTHR13869:SF3, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
PRINTSi | PR00213, MYELINP0 |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCN2B_MOUSE | |
Accessioni | Q56A07Primary (citable) accession number: Q56A07 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families