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Entry version 128 (11 Dec 2019)
Sequence version 1 (10 May 2005)
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Protein

Zinc finger protein 385B

Gene

ZNF385B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in p53/TP53-mediated apoptosis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri34 – 64Matrin-type 1Add BLAST31
Zinc fingeri157 – 187Matrin-type 2Add BLAST31
Zinc fingeri282 – 316Matrin-type 3Add BLAST35
Zinc fingeri348 – 378Matrin-type 4Add BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 385B
Alternative name(s):
Zinc finger protein 533
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF385B
Synonyms:ZNF533
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000144331.18

Human Gene Nomenclature Database

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HGNCi
HGNC:26332 ZNF385B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612344 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q569K4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
151126

Open Targets

More...
OpenTargetsi
ENSG00000144331

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410114

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q569K4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF385B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74741028

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001918121 – 471Zinc finger protein 385BAdd BLAST471

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q569K4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q569K4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q569K4

PeptideAtlas

More...
PeptideAtlasi
Q569K4

PRoteomics IDEntifications database

More...
PRIDEi
Q569K4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62574 [Q569K4-1]
62575 [Q569K4-2]
62576 [Q569K4-3]
62577 [Q569K4-4]
62578 [Q569K4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q569K4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q569K4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in germinal center of lymph node (at protein level). Expressed in spleen, lymph node and tonsil.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144331 Expressed in 164 organ(s), highest expression level in layer of synovial tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q569K4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q569K4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046086

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with p53/TP53; the interaction is direct.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127344, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q569K4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386845

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q569K4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 93Required for induction of apoptosisAdd BLAST93
Regioni94 – 471Interaction with p53/TP531 PublicationAdd BLAST378

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 64Matrin-type 1Add BLAST31
Zinc fingeri157 – 187Matrin-type 2Add BLAST31
Zinc fingeri282 – 316Matrin-type 3Add BLAST35
Zinc fingeri348 – 378Matrin-type 4Add BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHAD Eukaryota
ENOG410Y1ZH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231865

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q569K4

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAGSTCH

Database of Orthologous Groups

More...
OrthoDBi
899600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q569K4

TreeFam database of animal gene trees

More...
TreeFami
TF326622

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q569K4-1) [UniParc]FASTAAdd to basket
Also known as: IF-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNMANFLRGF EEKGIKNDRP EDQLSKEKKK ILFSFCEVCN IQLNSAAQAQ
60 70 80 90 100
VHSNGKSHRK RVKQLSDGQP PPPAQASPSS NSSTGSTCHT TTLPALVRTP
110 120 130 140 150
TLMMQPSLDI KPFMSFPVDS SSAVGLFPNF NTMDPVQKAV INHTFGVSIP
160 170 180 190 200
PKKKQVISCN VCQLRFNSDS QAEAHYKGSK HAKKVKALDA TKNKPKMVPS
210 220 230 240 250
KDSAKANPSC SITPITGNNS DKSEDKGKLK ASSSSQPSSS ESGSFLLKSG
260 270 280 290 300
TTPLPPGAAT SPSKSTNGAP GTVVESEEEK AKKLLYCSLC KVAVNSLSQL
310 320 330 340 350
EAHNTGSKHK TMVEARNGAG PIKSYPRPGS RLKMQNGSKG SGLQNKTFHC
360 370 380 390 400
EICDVHVNSE IQLKQHISSR RHKDRVAGKP LKPKYSPYNK LQRSPSILAA
410 420 430 440 450
KLAFQKDMMK PLAPAFLSSP LAAAAAVSSA LSLPPRPSAS LFQAPAIPPA
460 470
LLRPGHGPIR ATPASILFAP Y
Length:471
Mass (Da):50,407
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i052813B99B908515
GO
Isoform 2 (identifier: Q569K4-2) [UniParc]FASTAAdd to basket
Also known as: IF-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     77-84: SPSSNSST → MWSGLPSR

Note: Major isoform in tonsil.Curated
Show »
Length:395
Mass (Da):42,026
Checksum:i381EC071BE954735
GO
Isoform 3 (identifier: Q569K4-3) [UniParc]FASTAAdd to basket
Also known as: IF-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Note: Major isoform in lymph node.Curated
Show »
Length:369
Mass (Da):39,260
Checksum:iC46C768667FA500F
GO
Isoform 4 (identifier: Q569K4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.
     366-368: HIS → PKA
     369-471: Missing.

Show »
Length:172
Mass (Da):17,957
Checksum:i9F108157F234129F
GO
Isoform 5 (identifier: Q569K4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRYSLSPDNHLEDGIM
     386-406: SPYNKLQRSPSILAAKLAFQK → TPCKVIGLLPKPLPPANRQLS
     407-471: Missing.

Show »
Length:421
Mass (Da):45,476
Checksum:i4C83553AFEC24036
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JKK0C9JKK0_HUMAN
Zinc finger protein 385B
ZNF385B
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PB85E9PB85_HUMAN
Zinc finger protein 385B
ZNF385B
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZT0A0A2U3TZT0_HUMAN
Zinc finger protein 385B
ZNF385B
486Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPH4C9JPH4_HUMAN
Zinc finger protein 385B
ZNF385B
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0U3C9J0U3_HUMAN
Zinc finger protein 385B
ZNF385B
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti254L → P in BAB71629 (PubMed:14702039).Curated1
Sequence conflicti415A → S in BAC04870 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053765242S → G. Corresponds to variant dbSNP:rs2271761Ensembl.1
Natural variantiVAR_076447416F → Y1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0159721 – 196Missing in isoform 4. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0159731 – 102Missing in isoform 3. 2 PublicationsAdd BLAST102
Alternative sequenceiVSP_0159741 – 76Missing in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_0159751M → MRYSLSPDNHLEDGIM in isoform 5. 1 Publication1
Alternative sequenceiVSP_01597677 – 84SPSSNSST → MWSGLPSR in isoform 2. 1 Publication8
Alternative sequenceiVSP_015977366 – 368HIS → PKA in isoform 4. 1 Publication3
Alternative sequenceiVSP_015978369 – 471Missing in isoform 4. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_015979386 – 406SPYNK…LAFQK → TPCKVIGLLPKPLPPANRQL S in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_015980407 – 471Missing in isoform 5. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057999 mRNA Translation: BAB71629.1
AK096822 mRNA Translation: BAC04870.1
AK131432 mRNA Translation: BAD18578.1
BC038422 mRNA Translation: AAH38422.1
BC048123 mRNA Translation: AAH48123.1
BC092423 mRNA Translation: AAH92423.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46463.1 [Q569K4-2]
CCDS46464.1 [Q569K4-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001106868.1, NM_001113397.1 [Q569K4-2]
NP_001106869.1, NM_001113398.1 [Q569K4-3]
NP_001269654.1, NM_001282725.1 [Q569K4-3]
NP_689733.3, NM_152520.4
XP_016858927.1, XM_017003438.1
XP_016858928.1, XM_017003439.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336917; ENSP00000338225; ENSG00000144331 [Q569K4-3]
ENST00000409343; ENSP00000386379; ENSG00000144331 [Q569K4-2]
ENST00000409692; ENSP00000386507; ENSG00000144331 [Q569K4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
151126

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:151126

UCSC genome browser

More...
UCSCi
uc002unj.4 human [Q569K4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057999 mRNA Translation: BAB71629.1
AK096822 mRNA Translation: BAC04870.1
AK131432 mRNA Translation: BAD18578.1
BC038422 mRNA Translation: AAH38422.1
BC048123 mRNA Translation: AAH48123.1
BC092423 mRNA Translation: AAH92423.1
CCDSiCCDS46463.1 [Q569K4-2]
CCDS46464.1 [Q569K4-3]
RefSeqiNP_001106868.1, NM_001113397.1 [Q569K4-2]
NP_001106869.1, NM_001113398.1 [Q569K4-3]
NP_001269654.1, NM_001282725.1 [Q569K4-3]
NP_689733.3, NM_152520.4
XP_016858927.1, XM_017003438.1
XP_016858928.1, XM_017003439.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGridi127344, 3 interactors
IntActiQ569K4, 1 interactor
STRINGi9606.ENSP00000386845

PTM databases

iPTMnetiQ569K4
PhosphoSitePlusiQ569K4

Polymorphism and mutation databases

BioMutaiZNF385B
DMDMi74741028

Proteomic databases

jPOSTiQ569K4
MassIVEiQ569K4
PaxDbiQ569K4
PeptideAtlasiQ569K4
PRIDEiQ569K4
ProteomicsDBi62574 [Q569K4-1]
62575 [Q569K4-2]
62576 [Q569K4-3]
62577 [Q569K4-4]
62578 [Q569K4-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
151126

Genome annotation databases

EnsembliENST00000336917; ENSP00000338225; ENSG00000144331 [Q569K4-3]
ENST00000409343; ENSP00000386379; ENSG00000144331 [Q569K4-2]
ENST00000409692; ENSP00000386507; ENSG00000144331 [Q569K4-3]
GeneIDi151126
KEGGihsa:151126
UCSCiuc002unj.4 human [Q569K4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
151126
DisGeNETi151126
EuPathDBiHostDB:ENSG00000144331.18

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF385B
HGNCiHGNC:26332 ZNF385B
HPAiHPA046086
MIMi612344 gene
neXtProtiNX_Q569K4
OpenTargetsiENSG00000144331
PharmGKBiPA162410114

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHAD Eukaryota
ENOG410Y1ZH LUCA
GeneTreeiENSGT00940000155611
HOGENOMiHOG000231865
InParanoidiQ569K4
OMAiSAGSTCH
OrthoDBi899600at2759
PhylomeDBiQ569K4
TreeFamiTF326622

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF385B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
151126
PharosiQ569K4 Tbio

Protein Ontology

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PROi
PR:Q569K4
RNActiQ569K4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000144331 Expressed in 164 organ(s), highest expression level in layer of synovial tissue
ExpressionAtlasiQ569K4 baseline and differential
GenevisibleiQ569K4 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 4 hits
SUPFAMiSSF57667 SSF57667, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ385B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q569K4
Secondary accession number(s): Q49A04
, Q6ZMZ7, Q8IY01, Q8N8H2, Q96DK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 10, 2005
Last modified: December 11, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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