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Entry version 94 (02 Jun 2021)
Sequence version 2 (26 Feb 2008)
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Protein

Uncharacterized protein C5orf47

Gene

C5orf47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q569G3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C5orf47
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C5orf47
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:27026, C5orf47

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q569G3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000185056.9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
133491

Open Targets

More...
OpenTargetsi
ENSG00000185056

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380318

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q569G3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C5orf47

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189045879

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003218211 – 176Uncharacterized protein C5orf47Add BLAST176

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q569G3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q569G3

PeptideAtlas

More...
PeptideAtlasi
Q569G3

PRoteomics IDEntifications database

More...
PRIDEi
Q569G3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62569

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q569G3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q569G3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185056, Expressed in female gonad and 46 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q569G3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185056, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340887

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q569G3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 109DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 107Polar residuesSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502T1NK, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00640000091672

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1495669_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q569G3

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGCRQEK

Database of Orthologous Groups

More...
OrthoDBi
1464474at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q569G3

TreeFam database of animal gene trees

More...
TreeFami
TF337018

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031464, DUF4680

The PANTHER Classification System

More...
PANTHERi
PTHR38655, PTHR38655, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15730, DUF4680, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q569G3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGRGREQ DSARFVYVTR FGSHQCSGVL QLGGRGAQGL WGQGPGAGCR
60 70 80 90 100
QEKPREAMAV AGVQGGSELP LGSQLRVPTT PGVEAAASAS SQLRASRVQS
110 120 130 140 150
GTRQSARAGL IQKDAAKKYD FPIPLNEASK IMKKKKKVLV WNRVYKVISR
160 170
MLEENEKYRH RLKCQRLSSE SSNYTR
Length:176
Mass (Da):19,206
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BB4A32AA7DDA1A0
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34971 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH92489 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC093275 Genomic DNA No translation available.
AC113423 Genomic DNA No translation available.
BC034971 mRNA Translation: AAH34971.1 Different initiation.
BC092489 mRNA Translation: AAH92489.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS47343.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138426.1, NM_001144954.1
XP_016864517.1, XM_017009028.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340147; ENSP00000340887; ENSG00000185056

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
133491

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:133491

UCSC genome browser

More...
UCSCi
uc003mcw.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093275 Genomic DNA No translation available.
AC113423 Genomic DNA No translation available.
BC034971 mRNA Translation: AAH34971.1 Different initiation.
BC092489 mRNA Translation: AAH92489.1 Different initiation.
CCDSiCCDS47343.1
RefSeqiNP_001138426.1, NM_001144954.1
XP_016864517.1, XM_017009028.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000340887

PTM databases

iPTMnetiQ569G3
PhosphoSitePlusiQ569G3

Genetic variation databases

BioMutaiC5orf47
DMDMi189045879

Proteomic databases

MassIVEiQ569G3
PaxDbiQ569G3
PeptideAtlasiQ569G3
PRIDEiQ569G3
ProteomicsDBi62569

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
133491

Genome annotation databases

EnsembliENST00000340147; ENSP00000340887; ENSG00000185056
GeneIDi133491
KEGGihsa:133491
UCSCiuc003mcw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
133491
DisGeNETi133491

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C5orf47
HGNCiHGNC:27026, C5orf47
HPAiENSG00000185056, Tissue enriched (testis)
neXtProtiNX_Q569G3
OpenTargetsiENSG00000185056
PharmGKBiPA162380318
VEuPathDBiHostDB:ENSG00000185056.9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502T1NK, Eukaryota
GeneTreeiENSGT00640000091672
HOGENOMiCLU_1495669_0_0_1
InParanoidiQ569G3
OMAiAGCRQEK
OrthoDBi1464474at2759
PhylomeDBiQ569G3
TreeFamiTF337018

Enzyme and pathway databases

PathwayCommonsiQ569G3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
133491, 7 hits in 972 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C5orf47, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
133491
PharosiQ569G3, Tdark

Protein Ontology

More...
PROi
PR:Q569G3
RNActiQ569G3, protein

Gene expression databases

BgeeiENSG00000185056, Expressed in female gonad and 46 other tissues
GenevisibleiQ569G3, HS

Family and domain databases

InterProiView protein in InterPro
IPR031464, DUF4680
PANTHERiPTHR38655, PTHR38655, 1 hit
PfamiView protein in Pfam
PF15730, DUF4680, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE047_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q569G3
Secondary accession number(s): Q8IYU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 2, 2021
This is version 94 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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