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Protein

Calcium and integrin-binding family member 2

Gene

Cib2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process.By similarity

Miscellaneous

The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi116 – 1271PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1682PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium and integrin-binding family member 2
Gene namesi
Name:Cib2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1308718 Cib2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892891 – 187Calcium and integrin-binding family member 2Add BLAST187

Proteomic databases

PaxDbiQ568Z7
PRIDEiQ568Z7

Expressioni

Gene expression databases

BgeeiENSRNOG00000059834 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ568Z7 RN

Interactioni

Subunit structurei

Homodimer. Interacts with WHRN and MYO7A. Interacts with ITGA2B (via C-terminus cytoplasmic tail region) and ITGA7 (via C-terminus cytoplasmic tail region); the interactions are stabilized/increased in a calcium and magnesium-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013623

Structurei

3D structure databases

ProteinModelPortaliQ568Z7
SMRiQ568Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 101EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini103 – 138EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0038 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133737
HOGENOMiHOG000233019
HOVERGENiHBG107344
InParanoidiQ568Z7
OMAiPDCKLPL
OrthoDBiEOG091G0OJZ
PhylomeDBiQ568Z7
TreeFamiTF313865

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q568Z7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNKQTIFTE EQLDNYQDCT FFNKKDILKL HARFYELAPN LVPMDYRKSP
60 70 80 90 100
IVHVPMSLII QMPELRENPF KERIVEAFSE DGEGNLTFND FVDMFSVLCE
110 120 130 140 150
SAPRELKANY AFKIYDFNTD NFICKEDLEL TLARLTKSEL DEDEVVLVCD
160 170 180
KVIEEADLDG DGKLGFADFE DMIAKAPDFL STFHIRI
Length:187
Mass (Da):21,672
Last modified:May 10, 2005 - v1
Checksum:iB97050DCBC0A6E0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092630 mRNA Translation: AAH92630.1
RefSeqiNP_001015010.1, NM_001015010.1
UniGeneiRn.46320

Genome annotation databases

EnsembliENSRNOT00000078571; ENSRNOP00000071683; ENSRNOG00000059834
GeneIDi300719
KEGGirno:300719
UCSCiRGD:1308718 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092630 mRNA Translation: AAH92630.1
RefSeqiNP_001015010.1, NM_001015010.1
UniGeneiRn.46320

3D structure databases

ProteinModelPortaliQ568Z7
SMRiQ568Z7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013623

Proteomic databases

PaxDbiQ568Z7
PRIDEiQ568Z7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000078571; ENSRNOP00000071683; ENSRNOG00000059834
GeneIDi300719
KEGGirno:300719
UCSCiRGD:1308718 rat

Organism-specific databases

CTDi10518
RGDi1308718 Cib2

Phylogenomic databases

eggNOGiKOG0038 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00860000133737
HOGENOMiHOG000233019
HOVERGENiHBG107344
InParanoidiQ568Z7
OMAiPDCKLPL
OrthoDBiEOG091G0OJZ
PhylomeDBiQ568Z7
TreeFamiTF313865

Miscellaneous databases

PROiPR:Q568Z7

Gene expression databases

BgeeiENSRNOG00000059834 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ568Z7 RN

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCIB2_RAT
AccessioniPrimary (citable) accession number: Q568Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 10, 2005
Last modified: September 12, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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