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Entry version 109 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Na(+)/H(+) antiporter NhaA

Gene

nhaA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Na+/H+ antiporter that extrudes sodium in exchange for external protons. Can also transport lithium and potassium. Activity is pH-dependent.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Amiloride strongly reduces affinity for Na+, but does not change the Vmax.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=36 mM for Na+1 Publication
  2. KM=24 mM for Li+1 Publication

    pH dependencei

    Optimum pH is 8.5. Activity is null at pH 7.0 and increases as the pH increases from 7.0 to 8.5.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAntiport, Ion transport, Sodium transport, Transport
    LigandSodium

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.33.1.2, the nhaa na(+):h(+) antiporter (nhaa) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Na(+)/H(+) antiporter NhaA
    Alternative name(s):
    Sodium/proton antiporter NhaA
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:nhaA
    Ordered Locus Names:VP1228
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri223926 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002493 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
    Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
    Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
    Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
    Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
    Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
    Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
    Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
    Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
    Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
    Transmembranei356 – 376HelicalSequence analysisAdd BLAST21

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003344601 – 383Na(+)/H(+) antiporter NhaAAdd BLAST383

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    223926.28806216

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q56725

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG3004, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_015803_1_0_6

    KEGG Orthology (KO)

    More...
    KOi
    K03313

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MGLMLRC

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.1530.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01844, NhaA, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR023171, Na/H_antiporter_dom_sf
    IPR004670, NhaA

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR30341, PTHR30341, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF06965, Na_H_antiport_1, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00773, NhaA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q56725-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MNDVIRDFFK MESAGGILLV IAAAIAMTIA NSPLGETYQS LLHTYVFGMS
    60 70 80 90 100
    VSHWINDGLM AVFFLLIGLE VKRELLEGAL KSKETAIFPA IAAVGGMLAP
    110 120 130 140 150
    ALIYVAFNAN DPEAISGWAI PAATDIAFAL GIMALLGKRV PVSLKVFLLA
    160 170 180 190 200
    LAIIDDLGVV VIIALFYTGD LSSMALLVGF VMTGVLFMLN AKEVTKLTPY
    210 220 230 240 250
    MIVGAILWFA VLKSGVHATL AGVVIGFAIP LKGKQGEHSP LKHMEHALHP
    260 270 280 290 300
    YVAFGILPLF AFANAGISLE GVSMSGLTSM LPLGIALGLL IGKPLGIFSF
    310 320 330 340 350
    SWAAVKLGVA KLPEGINFKH IFAVSVLCGI GFTMSIFISS LAFGNVSPEF
    360 370 380
    DTYARLGILM GSTTAAVLGY ALLHFSLPKK AQD
    Length:383
    Mass (Da):40,433
    Last modified:November 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EE53D008D2FD6A2
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D28504 Genomic DNA Translation: BAA05864.1
    BA000031 Genomic DNA Translation: BAC59491.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JX0360

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_797607.1, NC_004603.1
    WP_005462393.1, NC_004603.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    BAC59491; BAC59491; BAC59491

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    48371183

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    vpa:VP1228

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|223926.6.peg.1168

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D28504 Genomic DNA Translation: BAA05864.1
    BA000031 Genomic DNA Translation: BAC59491.1
    PIRiJX0360
    RefSeqiNP_797607.1, NC_004603.1
    WP_005462393.1, NC_004603.1

    3D structure databases

    SMRiQ56725
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi223926.28806216

    Protein family/group databases

    TCDBi2.A.33.1.2, the nhaa na(+):h(+) antiporter (nhaa) family

    Genome annotation databases

    EnsemblBacteriaiBAC59491; BAC59491; BAC59491
    GeneIDi48371183
    KEGGivpa:VP1228
    PATRICifig|223926.6.peg.1168

    Phylogenomic databases

    eggNOGiCOG3004, Bacteria
    HOGENOMiCLU_015803_1_0_6
    KOiK03313
    OMAiMGLMLRC

    Family and domain databases

    Gene3Di1.20.1530.10, 1 hit
    HAMAPiMF_01844, NhaA, 1 hit
    InterProiView protein in InterPro
    IPR023171, Na/H_antiporter_dom_sf
    IPR004670, NhaA
    PANTHERiPTHR30341, PTHR30341, 1 hit
    PfamiView protein in Pfam
    PF06965, Na_H_antiport_1, 1 hit
    TIGRFAMsiTIGR00773, NhaA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNHAA_VIBPA
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q56725
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 1, 1996
    Last modified: October 7, 2020
    This is version 109 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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