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Protein

Ras association domain-containing protein 4

Gene

Rassf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 4
Gene namesi
Name:Rassf4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1307785 Rassf4

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404001 – 322Ras association domain-containing protein 4Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei142PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ566C5
PRIDEiQ566C5

Expressioni

Gene expression databases

BgeeiENSRNOG00000013526
GenevisibleiQ566C5 RN

Interactioni

Subunit structurei

Interacts directly with activated KRAS in a GTP-dependent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018101

Structurei

3D structure databases

ProteinModelPortaliQ566C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 263Ras-associatingPROSITE-ProRule annotationAdd BLAST89
Domaini271 – 318SARAHPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiKOG4239 Eukaryota
ENOG410Y2N1 LUCA
GeneTreeiENSGT00510000046426
HOGENOMiHOG000231738
HOVERGENiHBG054302
InParanoidiQ566C5
KOiK09851
OMAiMFLMEAD
OrthoDBiEOG091G0BOA
PhylomeDBiQ566C5
TreeFamiTF319243

Family and domain databases

InterProiView protein in InterPro
IPR033614 C-RASSF
IPR000159 RA_dom
IPR033622 RASSF4
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF4 PTHR22738:SF4, 1 hit
PfamiView protein in Pfam
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit

Sequencei

Sequence statusi: Complete.

Q566C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEDCSPSSH VPISDSKFIL KSELLSLLKT YNCYHEGRSF QLRHREEEGT
60 70 80 90 100
LIIEGLLNIA WGLRRPIRLQ MQDDRERVHL PSATWVPERL SYLQKDASPQ
110 120 130 140 150
DSKVPAEEPS TQPANKGEVS RDGSGPLQEE EEEVPQLMRT KSDASCIIQR
160 170 180 190 200
RCKSRAPGEA QKIRRHRFSI NGHFYNHKTS VFTPAYGSVT NVRVNSTMTT
210 220 230 240 250
QQVLTLLLNK FRVEDGPSEF ALYTVHESGE QTKLKDCEYP LISRILHGPC
260 270 280 290 300
EKIVKIFLME ADLSEEVPHD VAQYIKFEMP VLDSFVEKLK EEEEREIIKL
310 320
TMKFQALRLT MQQRLEQLVE AK
Length:322
Mass (Da):37,125
Last modified:May 10, 2005 - v1
Checksum:i0C23FEE5604BEFC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC093620 mRNA Translation: AAH93620.1
RefSeqiNP_001019446.1, NM_001024275.1
XP_017448190.1, XM_017592701.1
UniGeneiRn.195253

Genome annotation databases

EnsembliENSRNOT00000018101; ENSRNOP00000018101; ENSRNOG00000013526
GeneIDi362423
KEGGirno:362423
UCSCiRGD:1307785 rat

Similar proteinsi

Entry informationi

Entry nameiRASF4_RAT
AccessioniPrimary (citable) accession number: Q566C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 10, 2005
Last modified: November 22, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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