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UniProtKB - Q564P6 (Q564P6_MOUSE)
Protein
Submitted name:
Cyclin-dependent kinase inhibitor 1A variant 1
Gene
Cdkn1a
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cyclin-dependent protein kinase activating kinase activity Source: Ensembl
- cyclin-dependent protein serine/threonine kinase inhibitor activity Source: InterPro
- protein-containing complex binding Source: Ensembl
- protein kinase binding Source: Ensembl
- protein sequestering activity Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- cellular response to amino acid starvation Source: Ensembl
- cellular response to DNA damage stimulus Source: BHF-UCL
- cellular response to ionizing radiation Source: BHF-UCL
- cellular senescence Source: Ensembl
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
- mitotic G2 DNA damage checkpoint signaling Source: Ensembl
- negative regulation of cell growth Source: Ensembl
- negative regulation of DNA biosynthetic process Source: Ensembl
- negative regulation of protein binding Source: Ensembl
- negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- positive regulation of fibroblast proliferation Source: Ensembl
- positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
- Ras protein signal transduction Source: Ensembl
- regulation of cell cycle Source: BHF-UCL
- replicative senescence Source: BHF-UCL
Keywordsi
Molecular function | KinaseImported, Protein kinase inhibitorARBA annotation, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclin-dependent kinase inhibitor 1A variant 1ImportedSubmitted name: Cyclin-dependent kinase inhibitor 1A variant 2ImportedSubmitted name: p21Imported |
Gene namesi | Name:Cdkn1aImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:104556, Cdkn1a |
VEuPathDBi | HostDB:ENSMUSG00000023067 |
Subcellular locationi
Nucleus
- nuclear body Source: Ensembl
- nucleolus Source: Ensembl
- PCNA-p21 complex Source: Ensembl
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000023067, Expressed in stroma of bone marrow and 337 other tissues |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: Ensembl
- ubiquitin protein ligase binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 67 | CDIInterPro annotationAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 78 – 106 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 118 – 142 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the CDI family.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_077692_1_1_1 |
OMAi | KVCRRLF |
OrthoDBi | 1595421at2759 |
Family and domain databases
Gene3Di | 4.10.365.10, 1 hit |
InterProi | View protein in InterPro IPR003175, CDI_dom IPR044898, CDI_dom_sf IPR029841, CDKN1A |
PANTHERi | PTHR46778, PTHR46778, 1 hit |
Pfami | View protein in Pfam PF02234, CDI, 1 hit |
i Sequence
Sequence statusi: Complete.
Q564P6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNPGDVRPV PHRSKVCRCL FGPVDSEQLR RDCDALMAGC LQEARERWNF
60 70 80 90 100
DFVTETPLEG NFVWERVRSL GLPKVYLSPG SRSRDDLGGD KRPSTSSALL
110 120 130 140 150
QGPAPEDHVA LSLSCTLVSE RPEDSPGGPG TSQGRKRRQT SLTDFYHSKR
RLVFCKRKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH011321 Genomic DNA Translation: AAL57889.1 AY655697 Genomic DNA Translation: AAT73700.1 JX183731 Genomic DNA Translation: AGH67764.1 JX183731 Genomic DNA Translation: AGH67765.1 AB017817 mRNA Translation: BAA82341.1 AB017818 mRNA Translation: BAA82342.1 AK007630 mRNA Translation: BAB25148.1 AK089093 mRNA Translation: BAC40747.1 AK139306 mRNA Translation: BAE23949.1 AK149910 mRNA Translation: BAE29160.1 AK170467 mRNA Translation: BAE41815.1 |
RefSeqi | NP_001104569.1, NM_001111099.2 NP_031695.1, NM_007669.5 |
Genome annotation databases
GeneIDi | 12575 |
KEGGi | mmu:12575 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH011321 Genomic DNA Translation: AAL57889.1 AY655697 Genomic DNA Translation: AAT73700.1 JX183731 Genomic DNA Translation: AGH67764.1 JX183731 Genomic DNA Translation: AGH67765.1 AB017817 mRNA Translation: BAA82341.1 AB017818 mRNA Translation: BAA82342.1 AK007630 mRNA Translation: BAB25148.1 AK089093 mRNA Translation: BAC40747.1 AK139306 mRNA Translation: BAE23949.1 AK149910 mRNA Translation: BAE29160.1 AK170467 mRNA Translation: BAE41815.1 |
RefSeqi | NP_001104569.1, NM_001111099.2 NP_031695.1, NM_007669.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3757, 2430 antibodies from 47 providers |
DNASUi | 12575 |
Genome annotation databases
GeneIDi | 12575 |
KEGGi | mmu:12575 |
Organism-specific databases
CTDi | 1026 |
MGIi | MGI:104556, Cdkn1a |
VEuPathDBi | HostDB:ENSMUSG00000023067 |
Phylogenomic databases
HOGENOMi | CLU_077692_1_1_1 |
OMAi | KVCRRLF |
OrthoDBi | 1595421at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12575, 9 hits in 78 CRISPR screens |
ChiTaRSi | Cdkn1a, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023067, Expressed in stroma of bone marrow and 337 other tissues |
Family and domain databases
Gene3Di | 4.10.365.10, 1 hit |
InterProi | View protein in InterPro IPR003175, CDI_dom IPR044898, CDI_dom_sf IPR029841, CDKN1A |
PANTHERi | PTHR46778, PTHR46778, 1 hit |
Pfami | View protein in Pfam PF02234, CDI, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q564P6_MOUSE | |
Accessioni | Q564P6Primary (citable) accession number: Q564P6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |