Cyclin-dependent kinase inhibitor 1A variant 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cyclin-dependent protein kinase activating kinase activity Source: Ensembl
• cyclin-dependent protein serine/threonine kinase inhibitor activity Source: InterPro
• protein-containing complex binding Source: Ensembl
• protein kinase binding Source: Ensembl
• protein sequestering activity Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

GO - Biological processⁱ

• animal organ regeneration Source: Ensembl
• cell cycle arrest Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Feedback between p21 and reactive oxygen production is necessary for cell senescence."
    Passos J.F., Nelson G., Wang C., Richter T., Simillion C., Proctor C.J., Miwa S., Olijslagers S., Hallinan J., Wipat A., Saretzki G., Rudolph K.L., Kirkwood T.B., von Zglinicki T.
    Mol Syst Biol 6:347-347(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to amino acid starvation Source: Ensembl
• cellular response to DNA damage stimulus Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Feedback between p21 and reactive oxygen production is necessary for cell senescence."
    Passos J.F., Nelson G., Wang C., Richter T., Simillion C., Proctor C.J., Miwa S., Olijslagers S., Hallinan J., Wipat A., Saretzki G., Rudolph K.L., Kirkwood T.B., von Zglinicki T.
    Mol Syst Biol 6:347-347(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to heat Source: Ensembl
• cellular response to ionizing radiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Feedback between p21 and reactive oxygen production is necessary for cell senescence."
    Passos J.F., Nelson G., Wang C., Richter T., Simillion C., Proctor C.J., Miwa S., Olijslagers S., Hallinan J., Wipat A., Saretzki G., Rudolph K.L., Kirkwood T.B., von Zglinicki T.
    Mol Syst Biol 6:347-347(2010) [PubMed] [Europe PMC] [Abstract]
• cellular senescence Source: Ensembl
• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
• G1/S transition of mitotic cell cycle Source: Ensembl
• G2/M transition of mitotic cell cycle Source: Ensembl
• intestinal epithelial cell maturation Source: Ensembl
• mitotic G2 DNA damage checkpoint Source: Ensembl
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of cell growth Source: Ensembl
• negative regulation of DNA biosynthetic process Source: Ensembl
• negative regulation of protein binding Source: Ensembl
• negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
• positive regulation of cell death Source: Ensembl
• positive regulation of fibroblast proliferation Source: Ensembl
• positive regulation of reactive oxygen species metabolic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Feedback between p21 and reactive oxygen production is necessary for cell senescence."
    Passos J.F., Nelson G., Wang C., Richter T., Simillion C., Proctor C.J., Miwa S., Olijslagers S., Hallinan J., Wipat A., Saretzki G., Rudolph K.L., Kirkwood T.B., von Zglinicki T.
    Mol Syst Biol 6:347-347(2010) [PubMed] [Europe PMC] [Abstract]
• Ras protein signal transduction Source: Ensembl
• replicative senescence Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Feedback between p21 and reactive oxygen production is necessary for cell senescence."
    Passos J.F., Nelson G., Wang C., Richter T., Simillion C., Proctor C.J., Miwa S., Olijslagers S., Hallinan J., Wipat A., Saretzki G., Rudolph K.L., Kirkwood T.B., von Zglinicki T.
    Mol Syst Biol 6:347-347(2010) [PubMed] [Europe PMC] [Abstract]
• response to arsenic-containing substance Source: Ensembl
• response to corticosterone Source: Ensembl
• response to drug Source: Ensembl
• response to hyperoxia Source: Ensembl
• response to organonitrogen compound Source: Ensembl
• response to toxic substance Source: Ensembl
• response to X-ray Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSNPGDVRPV PHRSKVCRCL FGPVDSEQLR RDCDALMAGC LQEARERWNF 
        60         70         80         90        100
DFVTETPLEG NFVWERVRSL GLPKVYLSPG SRSRDDLGGD KRPSTSSALL 
       110        120        130        140        150
QGPAPEDHVA LSLSCTLVSE RPEDSPGGPG TSQGRKRRQT SLTDFYHSKR 

RLVFCKRKP                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ