Ldha

Functionⁱ

Catalytic activityⁱ

(S)-lactate + NAD⁺ = pyruvate + NADH.UniRule annotation

Pathwayⁱ: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhb), L-lactate dehydrogenase (Ldhc), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase B chain (Ldhb), L-lactate dehydrogenase (Ldhc), L-lactate dehydrogenase (Ldhal6b), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase A chain (Ldha), L-lactate dehydrogenase (Ldhb), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhc), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase C chain (Ldhc), L-lactate dehydrogenase (Ldhc)

This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	106	SubstrateUniRule annotation	1
Binding siteⁱ	138	SubstrateUniRule annotation	1
Binding siteⁱ	169	SubstrateUniRule annotation	1
Active siteⁱ	193	Proton acceptorUniRule annotation	1

GO - Molecular functionⁱ

L-lactate dehydrogenase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
carboxylic acid metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	OxidoreductaseUniRule annotation
Ligand	NADUniRule annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00554; UER00611

UniPathwayⁱ

UPA00554; UER00611

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesⁱ	Name:LdhaImported Synonyms:Ldh1Imported ORF Names:mCG_19938Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:96759 Ldha

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000063229

Bgeeⁱ

ENSMUSG00000063229

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 160	Ldh_1_NInterPro annotationAdd BLAST		139
Domainⁱ	164 – 324	Ldh_1_CInterPro annotationAdd BLAST		161

Sequence similaritiesⁱ

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1495 Eukaryota COG0039 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074541
HOVERGENⁱ	HBG000462
KEGG Orthology (KO) More...KOⁱ	K00016
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HME
TreeFamⁱ	TF314963

Family and domain databases

Gene3Dⁱ	3.90.110.10, 1 hit
HAMAPⁱ	MF_00488 Lactate_dehydrog, 1 hit
InterProⁱ	View protein in InterPro IPR001557 L-lactate/malate_DH IPR011304 L-lactate_DH IPR018177 L-lactate_DH_AS IPR022383 Lactate/malate_DH_C IPR001236 Lactate/malate_DH_N IPR015955 Lactate_DH/Glyco_Ohase_4_C IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02866 Ldh_1_C, 1 hit PF00056 Ldh_1_N, 1 hit
PIRSFⁱ	PIRSF000102 Lac_mal_DH, 1 hit
PRINTSⁱ	PR00086 LLDHDRGNASE
SUPFAMⁱ	SSF51735 SSF51735, 1 hit SSF56327 SSF56327, 1 hit
TIGRFAMsⁱ	TIGR01771 L-LDH-NAD, 1 hit
PROSITEⁱ	View protein in PROSITE PS00064 L_LDH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q564E2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATLKDQLIV NLLKEEQAPQ NKITVVGVGA VGMACAISIL MKDLADELAL 
        60         70         80         90        100
VDVMEDKLKG EMMDLQHGSL FLKTPKIVSS KDYCVTANSK LVIITAGARQ 
       110        120        130        140        150
QEGESRLNLV QRNVNIFKFI IPNIVKYSPH CKLLIVSNPV DILTYVAWKI 
       160        170        180        190        200
SGFPKNRVIG SGCNLDSARF RYLMGERLGV HALSCHGWVL GEHGDSSVPV 
       210        220        230        240        250
WSGVNVAGVS LKSLNPELGT DADKEQWKEV HKQVVDSAYE VIKLKGYTSW 
       260        270        280        290        300
AIGLSVADLA ESIMKNLRRV HPISTMIKGL YGINEDVFLS VPCILGQNGI 
       310        320        330 
SDVVKVTLTP EEEARLKKSA DTLWGIQKEL QF

Length:332

Mass (Da):36,499

Last modified:May 10, 2005 - v1

Checksum:ⁱ5AEB41E1E0B95100

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC090123 Genomic DNA No translation available. BC094019 mRNA Translation: AAH94019.1 BC094428 mRNA Translation: AAH94428.1 AK089929 mRNA Translation: BAC41000.1 AK150156 mRNA Translation: BAE29347.1 AK167789 mRNA Translation: BAE39819.1 AK168920 mRNA Translation: BAE40733.1 AK170386 mRNA Translation: BAE41760.1 CH466603 Genomic DNA Translation: EDL22946.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001129541.2, NM_001136069.2 NP_034829.1, NM_010699.2
UniGeneⁱ	Mm.29324

Genome annotation databases

Ensemblⁱ	ENSMUST00000005051; ENSMUSP00000103267; ENSMUSG00000063229
GeneIDⁱ	16828
KEGGⁱ	mmu:16828
UCSC genome browser More...UCSCⁱ	uc009gzo.2 mouse

Protein	Similar proteins		Species	Score	Length
Q564E2	L-lactate dehydrogenase A chain	)	HUMAN		332
UPI00083FD447		CALJA		393
L-lactate dehydrogenase		MACFA		364
UPI000D32003E		MACNE		364
UPI0004F1EB16		PAPAN		364
+123

Protein	Similar proteins		Species	Score	Length
Q564E2	L-lactate dehydrogenase A chain	)	HUMAN		332
UPI00083FD447		CALJA		393
UPI0004F1EB16		PAPAN		364
UPI000D32003E		MACNE		364
L-lactate dehydrogenase		MACFA		364
+226

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC090123 Genomic DNA No translation available. BC094019 mRNA Translation: AAH94019.1 BC094428 mRNA Translation: AAH94428.1 AK089929 mRNA Translation: BAC41000.1 AK150156 mRNA Translation: BAE29347.1 AK167789 mRNA Translation: BAE39819.1 AK168920 mRNA Translation: BAE40733.1 AK170386 mRNA Translation: BAE41760.1 CH466603 Genomic DNA Translation: EDL22946.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001129541.2, NM_001136069.2 NP_034829.1, NM_010699.2
UniGeneⁱ	Mm.29324

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000005051; ENSMUSP00000103267; ENSMUSG00000063229
GeneIDⁱ	16828
KEGGⁱ	mmu:16828
UCSC genome browser More...UCSCⁱ	uc009gzo.2 mouse

Organism-specific databases

CTDⁱ	3939
MGIⁱ	MGI:96759 Ldha

Phylogenomic databases

eggNOGⁱ	KOG1495 Eukaryota COG0039 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074541
HOVERGENⁱ	HBG000462
KEGG Orthology (KO) More...KOⁱ	K00016
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HME
TreeFamⁱ	TF314963

Enzyme and pathway databases

UniPathwayⁱ	UPA00554; UER00611

UniPathwayⁱ

UPA00554; UER00611

Miscellaneous databases

ChiTaRSⁱ	Ldha mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000063229

Bgeeⁱ

ENSMUSG00000063229

Family and domain databases

Gene3Dⁱ	3.90.110.10, 1 hit
HAMAPⁱ	MF_00488 Lactate_dehydrog, 1 hit
InterProⁱ	View protein in InterPro IPR001557 L-lactate/malate_DH IPR011304 L-lactate_DH IPR018177 L-lactate_DH_AS IPR022383 Lactate/malate_DH_C IPR001236 Lactate/malate_DH_N IPR015955 Lactate_DH/Glyco_Ohase_4_C IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02866 Ldh_1_C, 1 hit PF00056 Ldh_1_N, 1 hit
PIRSFⁱ	PIRSF000102 Lac_mal_DH, 1 hit
PRINTSⁱ	PR00086 LLDHDRGNASE
SUPFAMⁱ	SSF51735 SSF51735, 1 hit SSF56327 SSF56327, 1 hit
TIGRFAMsⁱ	TIGR01771 L-LDH-NAD, 1 hit
PROSITEⁱ	View protein in PROSITE PS00064 L_LDH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q564E2_MOUSE
Accessionⁱ	Q564E2Primary (citable) accession number: Q564E2 Secondary accession number(s): G5E8N5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	June 20, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q564E2 (Q564E2_MOUSE)

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L-lactate dehydrogenase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pyruvate fermentation to lactate

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: pyruvate fermentation to lactate

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ