UniProtKB - Q564E2 (Q564E2_MOUSE)
Protein
L-lactate dehydrogenase
Gene
Ldha
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:1.1.1.27UniRule annotationARBA annotation
: pyruvate fermentation to lactate Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- L-lactate dehydrogenase (Ldhb), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhb), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhc), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhc), L-lactate dehydrogenase B chain (Ldhb), L-lactate dehydrogenase (Ldhal6b), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhb), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase A chain (Ldha), L-lactate dehydrogenase (Ldhb), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhc), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhc), L-lactate dehydrogenase C chain (Ldhc)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 106 | SubstrateUniRule annotation | 1 | |
Binding sitei | 138 | SubstrateUniRule annotation | 1 | |
Binding sitei | 169 | SubstrateUniRule annotation | 1 | |
Active sitei | 193 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- L-lactate dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- carboxylic acid metabolic process Source: InterPro
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | NADUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00554;UER00611 |
Names & Taxonomyi
Protein namesi | Recommended name: L-lactate dehydrogenaseUniRule annotationARBA annotation (EC:1.1.1.27UniRule annotationARBA annotation) |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:96759, Ldha |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000063229, Expressed in ear vesicle and 334 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q564E2, 1 interactor |
Chemistry databases
BindingDBi | Q564E2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 160 | Ldh_1_NInterPro annotationAdd BLAST | 139 | |
Domaini | 164 – 324 | Ldh_1_CInterPro annotationAdd BLAST | 161 |
Sequence similaritiesi
Belongs to the LDH/MDH superfamily.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_045401_0_2_1 |
OMAi | MDLMQTA |
OrthoDBi | 1204514at2759 |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
HAMAPi | MF_00488, Lactate_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q564E2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATLKDQLIV NLLKEEQAPQ NKITVVGVGA VGMACAISIL MKDLADELAL
60 70 80 90 100
VDVMEDKLKG EMMDLQHGSL FLKTPKIVSS KDYCVTANSK LVIITAGARQ
110 120 130 140 150
QEGESRLNLV QRNVNIFKFI IPNIVKYSPH CKLLIVSNPV DILTYVAWKI
160 170 180 190 200
SGFPKNRVIG SGCNLDSARF RYLMGERLGV HALSCHGWVL GEHGDSSVPV
210 220 230 240 250
WSGVNVAGVS LKSLNPELGT DADKEQWKEV HKQVVDSAYE VIKLKGYTSW
260 270 280 290 300
AIGLSVADLA ESIMKNLRRV HPISTMIKGL YGINEDVFLS VPCILGQNGI
310 320 330
SDVVKVTLTP EEEARLKKSA DTLWGIQKEL QF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC094019 mRNA Translation: AAH94019.1 BC094428 mRNA Translation: AAH94428.1 AK089929 mRNA Translation: BAC41000.1 AK150156 mRNA Translation: BAE29347.1 AK167789 mRNA Translation: BAE39819.1 AK168920 mRNA Translation: BAE40733.1 AK170386 mRNA Translation: BAE41760.1 |
RefSeqi | NP_001129541.2, NM_001136069.2 NP_034829.1, NM_010699.2 |
Genome annotation databases
GeneIDi | 16828 |
KEGGi | mmu:16828 |
UCSCi | uc009gzo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC094019 mRNA Translation: AAH94019.1 BC094428 mRNA Translation: AAH94428.1 AK089929 mRNA Translation: BAC41000.1 AK150156 mRNA Translation: BAE29347.1 AK167789 mRNA Translation: BAE39819.1 AK168920 mRNA Translation: BAE40733.1 AK170386 mRNA Translation: BAE41760.1 |
RefSeqi | NP_001129541.2, NM_001136069.2 NP_034829.1, NM_010699.2 |
3D structure databases
SMRi | Q564E2 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q564E2, 1 interactor |
Chemistry databases
BindingDBi | Q564E2 |
Proteomic databases
EPDi | Q564E2 |
MaxQBi | Q564E2 |
PRIDEi | Q564E2 |
ProteomicsDBi | 343100 |
Protocols and materials databases
Antibodypediai | 4200, 891 antibodies |
DNASUi | 16828 |
Genome annotation databases
GeneIDi | 16828 |
KEGGi | mmu:16828 |
UCSCi | uc009gzo.2, mouse |
Organism-specific databases
CTDi | 3939 |
MGIi | MGI:96759, Ldha |
Phylogenomic databases
HOGENOMi | CLU_045401_0_2_1 |
OMAi | MDLMQTA |
OrthoDBi | 1204514at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00554;UER00611 |
Miscellaneous databases
BioGRID-ORCSi | 16828, 20 hits in 50 CRISPR screens |
ChiTaRSi | Ldha, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063229, Expressed in ear vesicle and 334 other tissues |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
HAMAPi | MF_00488, Lactate_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q564E2_MOUSE | |
Accessioni | Q564E2Primary (citable) accession number: Q564E2 Secondary accession number(s): G5E8N5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |