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Protein

Cytochrome c oxidase subunit 1

Gene

cbaA

Organism
Thermus thermophilus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • hemeBy similarityNote: Binds 2 heme groups.By similarity
  • Cu cationBy similarityNote: Binds a copper B center.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Iron (heme A3 axial ligand)By similarity1
Metal bindingi51Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit I
Cytochrome c oxidase polypeptide I
Cytochrome cba3 subunit 1
Gene namesi
Name:cbaA
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183463‹1 – ›108Cytochrome c oxidase subunit 1Add BLAST›108

Interactioni

Protein-protein interaction databases

IntActiQ56408, 2 interactors

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ56408
SMRiQ56408
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56408

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RQ2 Bacteria
COG0843 LUCA

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PfamiView protein in Pfam
PF00115 COX1, 1 hit
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Fragment.

Q56408-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IRALPWDNPA FVAPVLGLLG FIPGGAGGIV NASFTLDYVV HNTAWVPGHF
60 70 80 90 100
HLQVASLVTL TAMGSLYWLL PNLTGKPISD AQRRLGLAVV WLWFLGMMIM

AVGLHWAG
Length:108
Mass (Da):11,634
Last modified:March 29, 2005 - v2
Checksum:i7DEB6C38DD575368
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84206 Genomic DNA Translation: CAB06339.1
PIRiT52481

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z84206 Genomic DNA Translation: CAB06339.1
PIRiT52481

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30A1-108[»]
ProteinModelPortaliQ56408
SMRiQ56408
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ56408, 2 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4107RQ2 Bacteria
COG0843 LUCA

Enzyme and pathway databases

UniPathwayi
UPA00705

Miscellaneous databases

EvolutionaryTraceiQ56408

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PfamiView protein in Pfam
PF00115 COX1, 1 hit
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_THETH
AccessioniPrimary (citable) accession number: Q56408
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 29, 2005
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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