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Entry version 91 (10 Feb 2021)
Sequence version 1 (10 May 2005)
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Protein

Non-specific serine/threonine protein kinase

Gene

trpm7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1533ATPUniRule annotation1
Binding sitei1557ATPUniRule annotation1
Binding sitei1629ATPUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1662ZincUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1676Proton acceptorUniRule annotation1
Binding sitei1678ATPUniRule annotation1
Binding sitei1686ATPUniRule annotation1
Metal bindingi1719ZincUniRule annotation1
Metal bindingi1721ZincUniRule annotation1
Metal bindingi1725ZincUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, KinaseARBA annotation, ReceptorImported, Transferase
Biological processCalcium transport, Ion transport, Transport
LigandATP-bindingUniRule annotation, Calcium, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpm7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-021115-2, trpm7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1503 – 1733Alpha-type protein kinaseInterPro annotationAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni541 – 566DisorderedSequence analysisAdd BLAST26
Regioni1352 – 1387DisorderedSequence analysisAdd BLAST36
Regioni1399 – 1420DisorderedSequence analysisAdd BLAST22
Regioni1436 – 1455DisorderedSequence analysisAdd BLAST20
Regioni1739 – 1768DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi541 – 556PolarSequence analysisAdd BLAST16
Compositional biasi1368 – 1387PolarSequence analysisAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Database of Orthologous Groups

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OrthoDBi
738147at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1010, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR011009, Kinase-like_dom_sf
IPR004166, MHCK_EF2_kinase
IPR029601, TRPM7
IPR041491, TRPM_SLOG
IPR032415, TRPM_tetra
IPR037162, TRPM_tetra_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF8, PTHR13800:SF8, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02816, Alpha_kinase, 1 hit
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit
PF16519, TRPM_tetra, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00811, Alpha_kinase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51158, ALPHA_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q563W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQKSWIEHT FTRRECVYIL PVSKDPHRCL PGCQICQQLV RCCCGRLVRQ
60 70 80 90 100
HVGFTATLAV KYSEVSEELS ELEQWSVEKH TEESPTDAYG VINFQGGSHS
110 120 130 140 150
YRAKYVRLSH DSRPEAVLRL MLKEWLMELP KIVISVHGGI QNFELHPRIK
160 170 180 190 200
QVVGKGLIKA AVTTGAWILT GGVNTGVAKH VGDALKEHLS RSARKICTVG
210 220 230 240 250
IAPWGVIENR NDLIGRDVVA PYQTLLNPLS KLNVLNNFHS HFLLVDDGTV
260 270 280 290 300
GKYGAEVRLR RELEKHIQLQ RIHARIGQGV PVVALIFEGG PNVILTVLEY
310 320 330 340 350
LQESPPVPVV VCEGTGRAAD ILAYVHKQTE QDGALPDGVE SDIIATIKKT
360 370 380 390 400
FNFSHGDALH LFQTLMECMK NKELITVFPV GSEDHQDIDV AILKALLKGT
410 420 430 440 450
NATAFDQLVL TLAWDRVDIA KDHVFVYGQQ LLVGSLEQAM LDALVMDRVE
460 470 480 490 500
FVKLLIENGV SMHRFLTITR LEELYNTKQT PTNPTLYHLV RDVKQGNLPP
510 520 530 540 550
NYKITLIDVG LVIEYLMGGT YRCNYTRKRF RIIYNNLHGN SRRSGRHTSS
560 570 580 590 600
SHSHESFSIQ ADKKEKTRHN HFIKTAQPYK PRLDSVSELQ KKKSKEEVVD
610 620 630 640 650
VDDPETRRFP YPFNELLVWA VLMKRQKMSL FFWQHGEESM AKALVACRLL
660 670 680 690 700
RSLGDEAKKS DVVDDTSEEL KEYSSEFGTL AVDLLEQSFR QDETMAMKLL
710 720 730 740 750
TYELKNWSNS TCLKLAVSSR LRPFVAHTCT QMLLSDMWMG RLNMRKNSWY
760 770 780 790 800
KVILSILVPP AILLLEYKTK AEMSHIPQSQ DAHQSMEDSE HNLQHPDDIQ
810 820 830 840 850
MDVFKEVRMS DNAEMKSELE VHVRSRRLPI TRKFYAFYHA PIVKFWFNTL
860 870 880 890 900
FYIGFLMLYS FVVLVKMQDL PSPQEWVVIL YIFTLAVEKI REMFMSEGGK
910 920 930 940 950
ISQKIKVWFS DYFNISDFLA ILMFFVGFGL RLVSEVFIAG RIVYCLNIIF
960 970 980 990 1000
WYVRLLDILA VNQQAGPYVM MIGKMVANMF YIVVIMAVVL LSFGVPRKAI
1010 1020 1030 1040 1050
LYPEEEPSWT LAKDVVFQPY WMMYGEVYAY EIDVCANSSE EHVRDLCTTG
1060 1070 1080 1090 1100
VWLTPLLQAV YLFVQYILMV NLLIAFFNNV YLQVKSISNL VWKYQRYHFI
1110 1120 1130 1140 1150
LAYHDKPILP PPLILLSHAA SLLSSICRKR KKDSSTYGPK LFLTEEDQKK
1160 1170 1180 1190 1200
LHDFEEQCVE TYFHEKDDQF HSGSDERIRL TSDRVETMCV QLKEVGNKVN
1210 1220 1230 1240 1250
FIKRSLHTLD SQIGHLQDLS ALTVDTLKAL TAQRASEASK VHNQITRELS
1260 1270 1280 1290 1300
VSRNLAPEAV PPSKPGALVR CSVAFMPPNS MADSLFGGGV EAVQGAGLPH
1310 1320 1330 1340 1350
ASLTADGVQT PQMRRRGHQE HLSSAPAAAA SFFLSTPLPQ QQDLQAPPEE
1360 1370 1380 1390 1400
FGAFVGHKDE PEGQRSIPKE SAVSSPSRKT RDVGNMRTVN SYAGFTELDR
1410 1420 1430 1440 1450
NPSLLHPEST LSKQERTRVS LEDVSRYEDL LLGKSAQSSK LSPGDDASNT
1460 1470 1480 1490 1500
AIGSPFKPME SYQYSAVERN NLMRLSQSIP FTPVPPRGEP VSVYRLEESS
1510 1520 1530 1540 1550
PGSINNSMSS WAQRGLCAKI EFLSKEEMGG GLRRALKVLC TWSEYDILKP
1560 1570 1580 1590 1600
GHLYIVKSFL PEVVNTWQTI YREETVLHLC LREIQQQRAA QKLTFAFNQI
1610 1620 1630 1640 1650
RPKTIPYSPR FLEVFLLYCH SAGQWFAIEE CITGDFRKFN NNNGDEIVPT
1660 1670 1680 1690 1700
NLLEETMLAF SHWTYEYTRG ELLVLDLQGV GEILTDPSVI KSGEKGSYDM
1710 1720 1730 1740 1750
IFGPANLGDD AIRNFRAKHH CNSCCRKLKL PDLKRNDYTP DKLTLQHDPS
1760 1770
EGPSHSPPAG AATKELRPSM RLML
Length:1,774
Mass (Da):201,442
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBA914283186F7CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY860421 mRNA Translation: AAX58598.1

NCBI Reference Sequences

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RefSeqi
NP_001025232.1, NM_001030061.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
280653

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:280653

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY860421 mRNA Translation: AAX58598.1
RefSeqiNP_001025232.1, NM_001030061.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi280653
KEGGidre:280653

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54822
ZFINiZDB-GENE-021115-2, trpm7

Phylogenomic databases

OrthoDBi738147at2759

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR011009, Kinase-like_dom_sf
IPR004166, MHCK_EF2_kinase
IPR029601, TRPM7
IPR041491, TRPM_SLOG
IPR032415, TRPM_tetra
IPR037162, TRPM_tetra_sf
PANTHERiPTHR13800:SF8, PTHR13800:SF8, 2 hits
PfamiView protein in Pfam
PF02816, Alpha_kinase, 1 hit
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit
PF16519, TRPM_tetra, 1 hit
SMARTiView protein in SMART
SM00811, Alpha_kinase, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158, ALPHA_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ563W7_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q563W7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: February 10, 2021
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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