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Entry version 95 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Tungsten-containing formaldehyde ferredoxin oxidoreductase

Gene

for

Organism
Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidation of C1-C3 aldehydes. Involved in peptides fermentation.

Miscellaneous

A low amount of aldehyde ferredoxin oxidoreductase activity has been observed.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
  • [4Fe-4S] cluster1 PublicationNote: Binds 1 [4Fe-4S] cluster per subunit.1 Publication
  • W-bis(molybdopterin guanine dinucleotide)1 PublicationNote: Binds 1 W-bis(molybdopterin guanine dinucleotide) (W-bis-MGD) cofactor per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by arsenite, iodoacetate and cyanide.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Significant activity only with aliphatic aldehydes up to C3 and only at high concentration (15 mM).
  1. KM=62 mM for formaldehyde1 Publication
  1. Vmax=17.5 µmol/min/mg enzyme with formaldehyde as substrate1 Publication

pH dependencei

Optimum pH is above 10 (at 80 degrees Celsius).1 Publication

Temperature dependencei

Optimum temperature is above 90 degrees Celsius (at pH 8.4).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi284Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi287Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi291Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi493Iron-sulfur (4Fe-4S)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Tungsten

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.2.7.B2, 6302

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q56303

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tungsten-containing formaldehyde ferredoxin oxidoreductase (EC:1.2.7.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:for
ORF Names:OCC_05029
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri523849 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000015502 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000873251 – 621Tungsten-containing formaldehyde ferredoxin oxidoreductaseAdd BLAST621

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q56303

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AOR/FOR family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020364_1_0_2

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHHKDAW

Database of Orthologous Groups

More...
OrthoDBi
9593at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.569.10, 1 hit
1.10.599.10, 1 hit
3.60.9.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013984, Ald_Fedxn_OxRdtase_dom2
IPR013985, Ald_Fedxn_OxRdtase_dom3
IPR013983, Ald_Fedxn_OxRdtase_N
IPR036503, Ald_Fedxn_OxRdtase_N_sf
IPR001203, OxRdtase_Ald_Fedxn_C
IPR036021, Tungsten_al_ferr_oxy-like_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01314, AFOR_C, 1 hit
PF02730, AFOR_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00790, AFOR_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48310, SSF48310, 1 hit
SSF56228, SSF56228, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q56303-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGWWGKILR VDLTNNKVWV QEYSPEVAKN FIGGRGLAAW ILWNEAKNVD
60 70 80 90 100
PLGPKNKLVF ATGPFNGLPT PSGGKMVIAA KSPLTGGYGD GNLGTMATVH
110 120 130 140 150
LRKAGYDALV VEGKAKKPVY IYIEDDNVSI LSAEGLWGKT TFETERELKE
160 170 180 190 200
IHGKNVGILS IGPGGENLVK YAVVISQEGR AAGRPGMGAV MGSKKLKAVV
210 220 230 240 250
IKGTKEIPVA DKEKLKELSQ EAYDAILNSP GYPFWHRQGT MAAVEWTNEN
260 270 280 290 300
SALPTRNFSD GSFEFARSID GYTMEGMKVK QRGCPYCNMP CGNVVLDAEG
310 320 330 340 350
QESELDYENV ALLGSNLGIG KLNEVSVLNR IADEMGLDTI SLGVAISYVM
360 370 380 390 400
EAKEKGIIKD DDAPEFGDFK KAKQLALDIA YRRGELGNLA AEGVKVMSEK
410 420 430 440 450
LGAKDFAMHV KGLEVSGYNC YIYPAMALAY GTSSIGAHHK EAWVIAWEIG
460 470 480 490 500
TAPIEGEKAQ KVEYKITYDP EKAAKVIELQ RLRGGLFEML TACRLPWVEV
510 520 530 540 550
GLSLDYYPKL LEAITGVKYT WDDLYKAADR VYALMRAYWV REFNGNWSRE
560 570 580 590 600
MDYPPERWFK EGLKSGPYKG QHLEKDKYDA LLSEYYKLRG WDERGIPKKE
610 620
TLKELNLEFV IPELEKVTKL E
Length:621
Mass (Da):68,941
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95589C2DC4F18E13
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X83963 Genomic DNA Translation: CAA58795.1
CP006670 Genomic DNA Translation: EHR79871.1

NCBI Reference Sequences

More...
RefSeqi
WP_004066104.1, NC_022084.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
EHR79871; EHR79871; OCC_05029

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16548761

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tlt:OCC_05029

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83963 Genomic DNA Translation: CAA58795.1
CP006670 Genomic DNA Translation: EHR79871.1
RefSeqiWP_004066104.1, NC_022084.1

3D structure databases

SMRiQ56303
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiEHR79871; EHR79871; OCC_05029
GeneIDi16548761
KEGGitlt:OCC_05029

Phylogenomic databases

HOGENOMiCLU_020364_1_0_2
OMAiAHHKDAW
OrthoDBi9593at2157

Enzyme and pathway databases

BRENDAi1.2.7.B2, 6302
SABIO-RKiQ56303

Family and domain databases

Gene3Di1.10.569.10, 1 hit
1.10.599.10, 1 hit
3.60.9.10, 1 hit
InterProiView protein in InterPro
IPR013984, Ald_Fedxn_OxRdtase_dom2
IPR013985, Ald_Fedxn_OxRdtase_dom3
IPR013983, Ald_Fedxn_OxRdtase_N
IPR036503, Ald_Fedxn_OxRdtase_N_sf
IPR001203, OxRdtase_Ald_Fedxn_C
IPR036021, Tungsten_al_ferr_oxy-like_C
PfamiView protein in Pfam
PF01314, AFOR_C, 1 hit
PF02730, AFOR_N, 1 hit
SMARTiView protein in SMART
SM00790, AFOR_N, 1 hit
SUPFAMiSSF48310, SSF48310, 1 hit
SSF56228, SSF56228, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOR_THELN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q56303
Secondary accession number(s): H3ZJK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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