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Protein

Beta-actin-like protein 2

Gene

ACTBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.By similarity

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ562R1

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-actin-like protein 2
Alternative name(s):
Kappa-actin
Gene namesi
Name:ACTBL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169067.3
HGNCiHGNC:17780 ACTBL2
MIMi614835 gene
neXtProtiNX_Q562R1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169067
PharmGKBiPA142672651

Polymorphism and mutation databases

BioMutaiACTBL2
DMDMi172046825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188491 – 376Beta-actin-like protein 2Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45Methionine (R)-sulfoxideBy similarity1
Modified residuei48Methionine (R)-sulfoxideBy similarity1

Post-translational modificationi

Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).By similarity
Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).By similarity

Keywords - PTMi

Oxidation

Proteomic databases

EPDiQ562R1
MaxQBiQ562R1
PaxDbiQ562R1
PeptideAtlasiQ562R1
PRIDEiQ562R1
ProteomicsDBi62562

PTM databases

iPTMnetiQ562R1
PhosphoSitePlusiQ562R1
SwissPalmiQ562R1

Expressioni

Gene expression databases

BgeeiENSG00000169067 Expressed in 13 organ(s), highest expression level in temporal lobe
CleanExiHS_ACTBL2

Organism-specific databases

HPAiHPA041264
HPA041271

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with PFN1 and PFDN1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP97Q8IW352EBI-1773495,EBI-1566210

Protein-protein interaction databases

BioGridi131362, 188 interactors
IntActiQ562R1, 33 interactors
MINTiQ562R1
STRINGi9606.ENSP00000416706

Structurei

3D structure databases

ProteinModelPortaliQ562R1
SMRiQ562R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233339
HOVERGENiHBG003771
InParanoidiQ562R1
OMAiMIGRPRH
OrthoDBiEOG091G08LD
PhylomeDBiQ562R1
TreeFamiTF354237

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q562R1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDNELSALV VDNGSGMCKA GFGGDDAPRA VFPSMIGRPR HQGVMVGMGQ
60 70 80 90 100
KDCYVGDEAQ SKRGVLTLKY PIEHGVVTNW DDMEKIWYHT FYNELRVAPD
110 120 130 140 150
EHPILLTEAP LNPKINREKM TQIMFEAFNT PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVMDSGDGV THIVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYN
210 220 230 240 250
FTTTAEREIV RDVKEKLCYV ALDFEQEMVR AAASSSPERS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE AIFQPSFLGI ESSGIHETTF NSIMKCDVDI RKDLYANTVL
310 320 330 340 350
SGGSTMYPGI ADRMQKEIIT LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDEAGPPI VHRKCF
Length:376
Mass (Da):42,003
Last modified:February 26, 2008 - v2
Checksum:i6095D374964D71DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121T → I in AAX82242 (PubMed:16824795).Curated1
Sequence conflicti135V → A in AAX82260 (PubMed:16824795).Curated1
Sequence conflicti162H → L in AAX82259 (PubMed:16824795).Curated1
Sequence conflicti163I → T in AAX82193 (PubMed:16824795).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648504 mRNA No translation available.
CH471123 Genomic DNA Translation: EAW54967.1
BC137470 mRNA Translation: AAI37471.1
BC137473 mRNA Translation: AAI37474.1
AY970384 Genomic DNA Translation: AAX82193.1
AY970433 Genomic DNA Translation: AAX82242.1
AY970451 Genomic DNA Translation: AAX82259.1
AY970452 Genomic DNA Translation: AAX82260.1
CCDSiCCDS34163.1
RefSeqiNP_001017992.1, NM_001017992.3
UniGeneiHs.482167

Genome annotation databases

EnsembliENST00000423391; ENSP00000416706; ENSG00000169067
GeneIDi345651
KEGGihsa:345651
UCSCiuc003jrm.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648504 mRNA No translation available.
CH471123 Genomic DNA Translation: EAW54967.1
BC137470 mRNA Translation: AAI37471.1
BC137473 mRNA Translation: AAI37474.1
AY970384 Genomic DNA Translation: AAX82193.1
AY970433 Genomic DNA Translation: AAX82242.1
AY970451 Genomic DNA Translation: AAX82259.1
AY970452 Genomic DNA Translation: AAX82260.1
CCDSiCCDS34163.1
RefSeqiNP_001017992.1, NM_001017992.3
UniGeneiHs.482167

3D structure databases

ProteinModelPortaliQ562R1
SMRiQ562R1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131362, 188 interactors
IntActiQ562R1, 33 interactors
MINTiQ562R1
STRINGi9606.ENSP00000416706

PTM databases

iPTMnetiQ562R1
PhosphoSitePlusiQ562R1
SwissPalmiQ562R1

Polymorphism and mutation databases

BioMutaiACTBL2
DMDMi172046825

Proteomic databases

EPDiQ562R1
MaxQBiQ562R1
PaxDbiQ562R1
PeptideAtlasiQ562R1
PRIDEiQ562R1
ProteomicsDBi62562

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423391; ENSP00000416706; ENSG00000169067
GeneIDi345651
KEGGihsa:345651
UCSCiuc003jrm.3 human

Organism-specific databases

CTDi345651
EuPathDBiHostDB:ENSG00000169067.3
GeneCardsiACTBL2
HGNCiHGNC:17780 ACTBL2
HPAiHPA041264
HPA041271
MIMi614835 gene
neXtProtiNX_Q562R1
OpenTargetsiENSG00000169067
PharmGKBiPA142672651
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233339
HOVERGENiHBG003771
InParanoidiQ562R1
OMAiMIGRPRH
OrthoDBiEOG091G08LD
PhylomeDBiQ562R1
TreeFamiTF354237

Enzyme and pathway databases

SignaLinkiQ562R1

Miscellaneous databases

GenomeRNAii345651
PROiPR:Q562R1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169067 Expressed in 13 organ(s), highest expression level in temporal lobe
CleanExiHS_ACTBL2

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACTBL_HUMAN
AccessioniPrimary (citable) accession number: Q562R1
Secondary accession number(s): B2RPJ1
, Q562R2, Q562S9, Q562X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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