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Protein

Pumilio homolog 3

Gene

Pum3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pumilio homolog 3Curated
Gene namesi
Name:Pum3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1564753 Pum3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759311 – 647Pumilio homolog 3Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ562C7
PRIDEiQ562C7

PTM databases

iPTMnetiQ562C7
PhosphoSitePlusiQ562C7

Expressioni

Gene expression databases

BgeeiENSRNOG00000012574 Expressed in 9 organ(s), highest expression level in spleen
GenevisibleiQ562C7 RN

Interactioni

Subunit structurei

Interacts with PARP1 (via catalytic domain).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034834

Structurei

3D structure databases

ProteinModelPortaliQ562C7
SMRiQ562C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 509PUM-HDPROSITE-ProRule annotationAdd BLAST368
Repeati176 – 211Pumilio 1By similarityAdd BLAST36
Repeati212 – 247Pumilio 2By similarityAdd BLAST36
Repeati248 – 276Pumilio 3By similarityAdd BLAST29
Repeati288 – 324Pumilio 4By similarityAdd BLAST37
Repeati325 – 360Pumilio 5By similarityAdd BLAST36
Repeati361 – 396Pumilio 6By similarityAdd BLAST36
Repeati397 – 434Pumilio 7By similarityAdd BLAST38
Repeati435 – 503Pumilio 8By similarityAdd BLAST69
Repeati504 – 550Pumilio 9By similarityAdd BLAST47
Repeati551 – 595Pumilio 10By similarityAdd BLAST45
Repeati596 – 635Pumilio 11By similarityAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi105 – 117Nuclear localization signalBy similarityAdd BLAST13

Domaini

A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2050 Eukaryota
ENOG410XSHY LUCA
GeneTreeiENSGT00390000015757
HOGENOMiHOG000237322
HOVERGENiHBG052166
InParanoidiQ562C7
KOiK14844
OMAiREWYGPE
OrthoDBiEOG091G06QP
PhylomeDBiQ562C7
TreeFamiTF312954

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012959 CPL_dom
IPR033133 PUM-HD
IPR001313 Pumilio_RNA-bd_rpt
PfamiView protein in Pfam
PF08144 CPL, 1 hit
SMARTiView protein in SMART
SM00025 Pumilio, 6 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50302 PUM, 5 hits
PS50303 PUM_HD, 1 hit

Sequencei

Sequence statusi: Complete.

Q562C7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKGKKKIT GKSPQTSQGK NKFHKNSESS SAKAFPRKAA KEGGPKVTSK
60 70 80 90 100
NFEKGATKPG KKRVKQFKNK PQGGKGPKDK FQKANKFNKK RKFQPDGKSD
110 120 130 140 150
ESAAKKPKWD DFKKKKKELK QNRQLSDKTN YDVVVRAKHI WESLRRKDCD
160 170 180 190 200
KEKRVKLMSD LQKLIQGKIK TIAFAHDSTR VIQCLIQYGS EEQRKWAFEE
210 220 230 240 250
LQGDLVELSK AKYSRNIVKK FLMYGSKPQI AEIIRSFKGH VRKMLRHSEA
260 270 280 290 300
SAIVEYAYND KAILEQRNML TEELYGNTFQ LYKSADHPTL EKVLEVQPGK
310 320 330 340 350
LELILDEMKQ ILTPMAQKEA VIKHSLVHKV FLDFFTYAPP KLRSELIEAI
360 370 380 390 400
REAVVYLAHT HDGARVAMHC LWHGTPKDRK VIVKTMKTYV EKIANGQYSH
410 420 430 440 450
LVLLAAFDCI DDTKLVKQII ISEVISSLPS IVNDKYGRKV LLYLLSPRAP
460 470 480 490 500
AHLVPEIIQL LQKGDGNAHS KKDTAIRRRE LLESISPALL SYLQGHTREV
510 520 530 540 550
VLDKSVCVLV SDILGSATGD AQPAMDAIAG LAAEELYPGG KDGELHIAEH
560 570 580 590 600
PAGHLVLKWL IEQDKKIKEN GKEGCFAKTL VECVGMKNLK SWASINRGAI
610 620 630 640
VLSSLLQSCD QDVVNKVKAG LKTLIPTLEK TKSTSKGIQT LLEKLTA
Length:647
Mass (Da):72,786
Last modified:May 10, 2005 - v1
Checksum:i59AFDE6F6D502AC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092579 mRNA Translation: AAH92579.1
BC098744 mRNA Translation: AAH98744.2
RefSeqiNP_001020207.1, NM_001025036.1
XP_006231308.1, XM_006231246.3
UniGeneiRn.127943

Genome annotation databases

EnsembliENSRNOT00000033724; ENSRNOP00000034834; ENSRNOG00000012574
GeneIDi499339
KEGGirno:499339

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092579 mRNA Translation: AAH92579.1
BC098744 mRNA Translation: AAH98744.2
RefSeqiNP_001020207.1, NM_001025036.1
XP_006231308.1, XM_006231246.3
UniGeneiRn.127943

3D structure databases

ProteinModelPortaliQ562C7
SMRiQ562C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034834

PTM databases

iPTMnetiQ562C7
PhosphoSitePlusiQ562C7

Proteomic databases

PaxDbiQ562C7
PRIDEiQ562C7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033724; ENSRNOP00000034834; ENSRNOG00000012574
GeneIDi499339
KEGGirno:499339

Organism-specific databases

CTDi9933
RGDi1564753 Pum3

Phylogenomic databases

eggNOGiKOG2050 Eukaryota
ENOG410XSHY LUCA
GeneTreeiENSGT00390000015757
HOGENOMiHOG000237322
HOVERGENiHBG052166
InParanoidiQ562C7
KOiK14844
OMAiREWYGPE
OrthoDBiEOG091G06QP
PhylomeDBiQ562C7
TreeFamiTF312954

Miscellaneous databases

PROiPR:Q562C7

Gene expression databases

BgeeiENSRNOG00000012574 Expressed in 9 organ(s), highest expression level in spleen
GenevisibleiQ562C7 RN

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012959 CPL_dom
IPR033133 PUM-HD
IPR001313 Pumilio_RNA-bd_rpt
PfamiView protein in Pfam
PF08144 CPL, 1 hit
SMARTiView protein in SMART
SM00025 Pumilio, 6 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50302 PUM, 5 hits
PS50303 PUM_HD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPUM3_RAT
AccessioniPrimary (citable) accession number: Q562C7
Secondary accession number(s): Q4G054
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 10, 2005
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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