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Protein

Nucleus accumbens-associated protein 2

Gene

Nacc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleus accumbens-associated protein 2
Short name:
NAC-2
Alternative name(s):
BTB/POZ domain-containing protein 14A
Gene namesi
Name:Nacc2
Synonyms:Btbd14a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309292 Nacc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636701 – 585Nucleus accumbens-associated protein 2Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki296Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki426Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki453Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ562B4
PRIDEiQ562B4

PTM databases

PhosphoSitePlusiQ562B4

Interactioni

Subunit structurei

Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024786

Structurei

3D structure databases

ProteinModelPortaliQ562B4
SMRiQ562B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 94BTBPROSITE-ProRule annotationAdd BLAST65
Domaini348 – 445BENPROSITE-ProRule annotationAdd BLAST98

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000231834
HOVERGENiHBG052875
InParanoidiQ562B4
KOiK10486
PhylomeDBiQ562B4

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF10523 BEN, 1 hit
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q562B4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA
60 70 80 90 100
SSLYFRDLFS GNSKSAFELP GTVPPACFQQ ILSFCYTGKL TMAASEQLVV
110 120 130 140 150
MYTAGFLQIQ HIVERGTDLM FKVSSPHCDS QTAMIEDASS EPQSPCNQLQ
160 170 180 190 200
PATAAYATSP SVPIPLLTRV KHEAMEMPPA TGPGLASKRP LDTGPRDGVA
210 220 230 240 250
VATGAAGTPG TAPLKLPRVS YYGVPSLATL IPSIQQVPYP QGERTSPGAS
260 270 280 290 300
SLPTTDSSTS YHNEDEDDDE AYDTMVEEQY GQMYIKATGN YAVQEKPEPV
310 320 330 340 350
PLESRSCVLI RRDLVALPAS LISQIGYRCH PKLYSEGDPG EKLELVAGSG
360 370 380 390 400
VYITRGQLMN CHLCAGVKHK VLLRRLLATF FDRNTLANSC GTGIRSSTSD
410 420 430 440 450
PSRKPLDSRV LNAVKLYCQN FAPSFKESEM NVIAADMCTN ARRVRKRWLP
460 470 480 490 500
KIKSMLPEGV EMYRSVMGAS AASLPLDPEF PSAASQVFEQ RIYAERRNDA
510 520 530 540 550
ATIVALRTDA VNVDLSTSAN PAFEANEEVD GAGSVIQEVA APEQLPADGQ
560 570 580
SSPQAFEQGN TSSSRPQTPV ATATRRPEGT YAGTL
Length:585
Mass (Da):63,100
Last modified:December 12, 2006 - v2
Checksum:iE5DA8753AF7E3340
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V8D3G3V8D3_RAT
BTB (POZ) domain containing 14A
Nacc2 Btbd14a, rCG_45787
585Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03030473 Genomic DNA No translation available.
BC092608 mRNA Translation: AAH92608.1
RefSeqiNP_001094003.1, NM_001100533.1
UniGeneiRn.27698

Genome annotation databases

GeneIDi296583
KEGGirno:296583
UCSCiRGD:1309292 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03030473 Genomic DNA No translation available.
BC092608 mRNA Translation: AAH92608.1
RefSeqiNP_001094003.1, NM_001100533.1
UniGeneiRn.27698

3D structure databases

ProteinModelPortaliQ562B4
SMRiQ562B4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024786

PTM databases

PhosphoSitePlusiQ562B4

Proteomic databases

PaxDbiQ562B4
PRIDEiQ562B4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi296583
KEGGirno:296583
UCSCiRGD:1309292 rat

Organism-specific databases

CTDi138151
RGDi1309292 Nacc2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000231834
HOVERGENiHBG052875
InParanoidiQ562B4
KOiK10486
PhylomeDBiQ562B4

Miscellaneous databases

PROiPR:Q562B4

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF10523 BEN, 1 hit
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNACC2_RAT
AccessioniPrimary (citable) accession number: Q562B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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