UniProtKB - Q562A2 (ZFR_RAT)
Protein
Zinc finger RNA-binding protein
Gene
Zfr
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in postimplantation and gastrulation stages of development (By similarity). Binds to DNA and RNA (By similarity). Involved in the nucleocytoplasmic shuttling of STAU2.By similarity1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- double-stranded RNA binding Source: GO_Central
- single-stranded RNA binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding, RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger RNA-binding protein |
Gene namesi | Name:Zfr |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311890, Zfr |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasmic granule 1 Publication
- Chromosome By similarity
Note: Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules. Associated with chromosome foci in meiotic cells (By similarity).By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312722 | 1 – 1073 | Zinc finger RNA-binding proteinAdd BLAST | 1073 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 508 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 508 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 515 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 540 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 622 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1053 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q562A2 |
PaxDbi | Q562A2 |
PRIDEi | Q562A2 |
PTM databases
iPTMneti | Q562A2 |
PhosphoSitePlusi | Q562A2 |
Expressioni
Tissue specificityi
Expressed in hippocampus.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000011627, Expressed in Ammon's horn and 21 other tissues |
ExpressionAtlasi | Q562A2, baseline and differential |
Genevisiblei | Q562A2, RN |
Interactioni
Subunit structurei
Interacts with STAU2.
Found in a cytoplasmic mRNP complex with STAU2. Does not interact with STAU1.
1 PublicationProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016196 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 702 – 1072 | DZFPROSITE-ProRule annotationAdd BLAST | 371 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 302 | Ala-richAdd BLAST | 267 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3792, Eukaryota |
GeneTreei | ENSGT00940000155290 |
HOGENOMi | CLU_012026_1_0_1 |
InParanoidi | Q562A2 |
PhylomeDBi | Q562A2 |
Family and domain databases
Gene3Di | 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR006561, DZF_dom IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR043519, NT_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF07528, DZF, 1 hit |
SMARTi | View protein in SMART SM00572, DZF, 1 hit SM00355, ZnF_C2H2, 2 hits SM00451, ZnF_U1, 2 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS51703, DZF, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q562A2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIPICPVVSF TYVPSRLGED AKMATGNYFG FTHSGAAAAA AAAQYSQQPA
60 70 80 90 100
SGVAYSHPTT VASYTVHQAP VAAHTVTAAY APAAATVAVA RPAPVAVAAA
110 120 130 140 150
ATAAAYGGYP TAHTATDYGY TQRQQEAPPP PPPATTQNYQ DSYSYVRSTA
160 170 180 190 200
PAVAYDSKQY YQQPTATAAA VAAAAQPQPS VAETYYQTAP KAGYSQGATQ
210 220 230 240 250
YTQAQQARQV TAIKPATPSP ATTTFSIYPV SSTVQPVAAA ATVVPSYTQS
260 270 280 290 300
ATYSTTAVTY SGTSYSGYEA AVYSAASSYY QQQQQQQKQA AAAAAAAAAT
310 320 330 340 350
AAWTGTTFTK KTPFQNKQLK PKQPPKPPQI HYCDVCKISC AGPQVFILCI
360 370 380 390 400
YHESQCTFTS VYSVLCNSPI DQKDACGKLH LCRLCDVSCT GADAYAAHIR
410 420 430 440 450
GAKHQKVVKL HTKLGKPIPS TEPNVVSQAT SSTAVSASKP TASPSSIGAS
460 470 480 490 500
NCTLNTSSIA TTSVKGLSTT GNSSLNSTSN TKVSAVPTNM AAKKTSTPKI
510 520 530 540 550
NFVGGGNKLQ STGNKAEDLK GTDCIKNNPA ASAVQIPEVK QDAVSEPVTP
560 570 580 590 600
ASLAALQSDV QPVGHDYVEE VRNDEGKVIR FHCKLCECSF NDPNAKEMHL
610 620 630 640 650
KGRRHRLQYK KKVNPDLQVE VKPSIRARKI QEEKMRKQMQ KEEYWRRREE
660 670 680 690 700
EERWRMEIRR YEEDMYWRRM EEEQHHWDDR RRMPDGGYPH GPPGPLGLLG
710 720 730 740 750
VRPGMPPQPQ GPAPLRRPDS SDDRYVMTKH ATIYPTEEEL QAVQKIVSIT
760 770 780 790 800
ERALKLVSDS LSEHEKSKNK EGDDKKEGGK DRSLKGVLRV GVLAKGLLLR
810 820 830 840 850
GDRNVNLVLL CSEKPSKSLL SRIAENLPKQ LAVISPEKYD IKCAVSEAAI
860 870 880 890 900
ILNSCVEPKM QVTITLTSPI IREENMREGD VTSGMVKDPP DVLDRQKCLD
910 920 930 940 950
ALAALRHAKW FQARANGLQS CVIIIRILRD LCQRVPTWSD FPSWAMELLV
960 970 980 990 1000
EKAISSASSP QSPGDALRRV FECISSGIIL KGNPGLLDPC EKDPFDTLAT
1010 1020 1030 1040 1050
MTDQQREDIT SSAQFALRLL AFRQIHKVLG MDPLPQMNQR FNIHNNRKRR
1060 1070
RDSDGVDGFE AEGKKDKKDY DNF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHJ5 | A0A0H2UHJ5_RAT | Zinc finger RNA-binding protein | Zfr | 1,074 | Annotation score: | ||
B1WC00 | B1WC00_RAT | Zfr protein | Zfr rCG_23668 | 128 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 983 | N → S in AAH92648 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03015519 Genomic DNA No translation available. AABR03021812 Genomic DNA No translation available. AABR03017146 Genomic DNA No translation available. AABR03016281 Genomic DNA No translation available. AABR03012204 Genomic DNA No translation available. BC092648 mRNA Translation: AAH92648.1 |
Genome annotation databases
Ensembli | ENSRNOT00000080241; ENSRNOP00000075053; ENSRNOG00000011627 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03015519 Genomic DNA No translation available. AABR03021812 Genomic DNA No translation available. AABR03017146 Genomic DNA No translation available. AABR03016281 Genomic DNA No translation available. AABR03012204 Genomic DNA No translation available. BC092648 mRNA Translation: AAH92648.1 |
3D structure databases
SMRi | Q562A2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016196 |
PTM databases
iPTMneti | Q562A2 |
PhosphoSitePlusi | Q562A2 |
Proteomic databases
jPOSTi | Q562A2 |
PaxDbi | Q562A2 |
PRIDEi | Q562A2 |
Genome annotation databases
Ensembli | ENSRNOT00000080241; ENSRNOP00000075053; ENSRNOG00000011627 |
Organism-specific databases
RGDi | 1311890, Zfr |
Phylogenomic databases
eggNOGi | KOG3792, Eukaryota |
GeneTreei | ENSGT00940000155290 |
HOGENOMi | CLU_012026_1_0_1 |
InParanoidi | Q562A2 |
PhylomeDBi | Q562A2 |
Miscellaneous databases
PROi | PR:Q562A2 |
Gene expression databases
Bgeei | ENSRNOG00000011627, Expressed in Ammon's horn and 21 other tissues |
ExpressionAtlasi | Q562A2, baseline and differential |
Genevisiblei | Q562A2, RN |
Family and domain databases
Gene3Di | 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR006561, DZF_dom IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR043519, NT_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF07528, DZF, 1 hit |
SMARTi | View protein in SMART SM00572, DZF, 1 hit SM00355, ZnF_C2H2, 2 hits SM00451, ZnF_U1, 2 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS51703, DZF, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFR_RAT | |
Accessioni | Q562A2Primary (citable) accession number: Q562A2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | April 7, 2021 | |
This is version 86 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |