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Protein

NADH-quinone oxidoreductase subunit 6

Gene

nqo6

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.2 Publications

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.

Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 1 [4Fe-4S] cluster per subunit. This [4Fe-4S] cluster is referred to as N2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Iron-sulfur (4Fe-4S)1 Publication1
Metal bindingi46Iron-sulfur (4Fe-4S)1 Publication1
Metal bindingi111Iron-sulfur (4Fe-4S)1 Publication1
Metal bindingi140Iron-sulfur (4Fe-4S)1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-88-MONOMER

Protein family/group databases

TCDBi3.D.1.3.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit 6 (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I subunit 6
NDH-1 subunit 6
Gene namesi
Name:nqo6
Ordered Locus Names:TTHA0085
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001187632 – 181NADH-quinone oxidoreductase subunit 6Add BLAST180

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 15 different subunits, Nqo1 to Nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8 and Nqo10 to Nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9 and Nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers. This subunit interacts extensively with Nqo4.2 Publications

Protein-protein interaction databases

DIPiDIP-59264N
IntActiQ56218, 1 interactor
STRINGi300852.TTHA0085

Structurei

Secondary structure

1181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ56218
SMRiQ56218
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ56218

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Phylogenomic databases

eggNOGiENOG4105ES3 Bacteria
COG0377 LUCA
HOGENOMiHOG000228249
KOiK00331
OMAiEMMTTGA
PhylomeDBiQ56218

Family and domain databases

HAMAPiMF_01356 NDH1_NuoB, 1 hit
InterProiView protein in InterPro
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR006138 NADH_UQ_OxRdtase_20Kd_su
PfamiView protein in Pfam
PF01058 Oxidored_q6, 1 hit
TIGRFAMsiTIGR01957 nuoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01150 COMPLEX1_20K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56218-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKDLFERD VQELEREGIL FTTLEKLVAW GRSNSLWPAT FGLACCAIEM
60 70 80 90 100
MASTDARNDL ARFGSEVFRA SPRQADVMIV AGRLSKKMAP VMRRVWEQMP
110 120 130 140 150
DPKWVISMGA CASSGGMFNN YAIVQNVDSV VPVDVYVPGC PPRPEALIYA
160 170 180
VMQLQKKVRG QAYNERGERL PPVAAWKRTR G
Length:181
Mass (Da):20,239
Last modified:January 23, 2007 - v3
Checksum:iA1E030366E6692F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52917 Genomic DNA Translation: AAA97939.1
AP008226 Genomic DNA Translation: BAD69908.1
PIRiT11899
RefSeqiWP_011174271.1, NC_006461.1
YP_143351.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD69908; BAD69908; BAD69908
GeneIDi3168381
KEGGittj:TTHA0085
PATRICifig|300852.9.peg.83

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52917 Genomic DNA Translation: AAA97939.1
AP008226 Genomic DNA Translation: BAD69908.1
PIRiT11899
RefSeqiWP_011174271.1, NC_006461.1
YP_143351.1, NC_006461.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FUGX-ray3.306/F/O/X1-181[»]
2YBBelectron microscopy19.0061-181[»]
3I9VX-ray3.106/F1-181[»]
3IAMX-ray3.106/F1-181[»]
3IASX-ray3.156/F/O/X1-181[»]
3M9SX-ray4.506/F1-181[»]
4HEAX-ray3.306/G1-181[»]
ProteinModelPortaliQ56218
SMRiQ56218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59264N
IntActiQ56218, 1 interactor
STRINGi300852.TTHA0085

Protein family/group databases

TCDBi3.D.1.3.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD69908; BAD69908; BAD69908
GeneIDi3168381
KEGGittj:TTHA0085
PATRICifig|300852.9.peg.83

Phylogenomic databases

eggNOGiENOG4105ES3 Bacteria
COG0377 LUCA
HOGENOMiHOG000228249
KOiK00331
OMAiEMMTTGA
PhylomeDBiQ56218

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-88-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ56218

Family and domain databases

HAMAPiMF_01356 NDH1_NuoB, 1 hit
InterProiView protein in InterPro
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR006138 NADH_UQ_OxRdtase_20Kd_su
PfamiView protein in Pfam
PF01058 Oxidored_q6, 1 hit
TIGRFAMsiTIGR01957 nuoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01150 COMPLEX1_20K, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNQO6_THET8
AccessioniPrimary (citable) accession number: Q56218
Secondary accession number(s): Q5SM58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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