UniProtKB - Q561Z7 (Q561Z7_DANRE)
Protein
Submitted name:
Serine protease 1
Gene
prss1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- serine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- proteolysis Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Serine proteaseUniRule annotation |
Enzyme and pathway databases
Reactomei | R-DRE-1442490, Collagen degradation R-DRE-1592389, Activation of Matrix Metalloproteinases R-DRE-196741, Cobalamin (Cbl, vitamin B12) transport and metabolism R-DRE-6798695, Neutrophil degranulation R-DRE-6803157, Antimicrobial peptides |
Protein family/group databases
MEROPSi | S01.151 |
Names & Taxonomyi
Protein namesi | Submitted name: Serine protease 1ImportedSubmitted name: Try proteinImportedSubmitted name: Trypsinogen 2Imported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-010131-7, prss1 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_5015097788 | 16 – 247 | Sequence analysisAdd BLAST | 232 |
Keywords - PTMi
Disulfide bondARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000042993, Expressed in intestine and 37 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 245 | Peptidase S1InterPro annotationAdd BLAST | 221 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00990000203555 |
OrthoDBi | 1314811at2759 |
TreeFami | TF331065 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 3 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q561Z7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAFILLALF AVAYAAPLGD DDDKIVGGYE CTKNGVPYQV SLNSGYHFCG
60 70 80 90 100
GSLISNLWVV SAAHCYKSRV QVRLGEHNID VTEGTEQFIN SEKVIRHPSY
110 120 130 140 150
NSNTLDNDVM LIKLSSSAQI NSYVKTVSLP SSCASSGTSC LISGWGNMSA
160 170 180 190 200
SGSNYPSRLM CLNAPILSDS TCRNAYPGQI SSNMFCAGFM EGGKDSCQGD
210 220 230 240
SGGPVVCNNQ LQGIVSWGYG CAQRNKPGVY AKVCNFTTWI RNTMNSN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX539313 Genomic DNA No translation available. BC092664 mRNA Translation: AAH92664.1 BC165931 mRNA Translation: AAI65931.1 JQ999998 mRNA Translation: AGB67369.1 |
RefSeqi | NP_571783.2, NM_131708.2 |
Genome annotation databases
Ensembli | ENSDART00000077661; ENSDARP00000072127; ENSDARG00000042993 |
GeneIDi | 65223 |
KEGGi | dre:65223 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX539313 Genomic DNA No translation available. BC092664 mRNA Translation: AAH92664.1 BC165931 mRNA Translation: AAI65931.1 JQ999998 mRNA Translation: AGB67369.1 |
RefSeqi | NP_571783.2, NM_131708.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000072127 |
Protein family/group databases
MEROPSi | S01.151 |
Genome annotation databases
Ensembli | ENSDART00000077661; ENSDARP00000072127; ENSDARG00000042993 |
GeneIDi | 65223 |
KEGGi | dre:65223 |
Organism-specific databases
CTDi | 5644 |
ZFINi | ZDB-GENE-010131-7, prss1 |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00990000203555 |
OrthoDBi | 1314811at2759 |
TreeFami | TF331065 |
Enzyme and pathway databases
Reactomei | R-DRE-1442490, Collagen degradation R-DRE-1592389, Activation of Matrix Metalloproteinases R-DRE-196741, Cobalamin (Cbl, vitamin B12) transport and metabolism R-DRE-6798695, Neutrophil degranulation R-DRE-6803157, Antimicrobial peptides |
Gene expression databases
Bgeei | ENSDARG00000042993, Expressed in intestine and 37 other tissues |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 3 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q561Z7_DANRE | |
Accessioni | Q561Z7Primary (citable) accession number: Q561Z7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |