UniProtKB - Q561U0 (Q561U0_DANRE)
Protein
Calcium-activated neutral proteinase 2
Gene
capn2l
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Catalytic activityi
- Broad endopeptidase specificity.ARBA annotation EC:3.4.22.53
Cofactori
Ca2+ARBA annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 585 – 596 | PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 615 – 626 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- hydrolase activity Source: UniProtKB-KW
GO - Biological processi
- proteolysis Source: GOC
- regulation of cytoskeleton organization Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Ligand | CalciumPROSITE-ProRule annotation |
Protein family/group databases
MEROPSi | C02.002 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-activated neutral proteinase 2ARBA annotation (EC:3.4.22.53ARBA annotation)Alternative name(s): Calpain M-typeARBA annotation Calpain-2 catalytic subunitARBA annotation Calpain-2 large subunitARBA annotation Millimolar-calpainARBA annotation |
Gene namesi | Name:capn2lImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-050417-341, capn2l |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation
Other locations
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSDARG00000034211, Expressed in caudal fin and 28 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C2 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG0045, Eukaryota |
HOGENOMi | CLU_010982_0_1_1 |
OMAi | MQKLIRI |
TreeFami | TF314748 |
Family and domain databases
CDDi | cd00214, Calpain_III, 1 hit cd00044, CysPc, 1 hit |
InterProi | View protein in InterPro IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR029539, CAPN2 IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR001300, Peptidase_C2_calpain_cat |
PANTHERi | PTHR10183:SF268, PTHR10183:SF268, 1 hit |
Pfami | View protein in Pfam PF01067, Calpain_III, 1 hit PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00720, calpain_III, 1 hit SM00230, CysPc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49758, SSF49758, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50203, CALPAIN_CAT, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS00139, THIOL_PROTEASE_CYS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q561U0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGIATKLQK NRARAAGIGT NAQAAKFLNQ DYEALKRECL ESGRLFQDGM
60 70 80 90 100
FEANVSALGF KELGPNSSKV RGVEWLRPKQ LTSNPTFISG GATRTDICQG
110 120 130 140 150
ALGDCWLLAA IASLTLNQDV FARVVPAGQS FDGDYAGIFH FQFWQFGEWV
160 170 180 190 200
DVVIDDRLPA RKGELLFVHS AEGSEFWSAL LEKAYAKLNG CYEALSGGTT
210 220 230 240 250
TEGFEDFTGG IAEVHELPKA GPNLFKTIQK ALSWGSLLGC SIDITSSSDS
260 270 280 290 300
EAITSQKLVK GHAYSVTGAE EVEYRGDLTK LIRIRNPWGQ VEWTGPWSDG
310 320 330 340 350
SSEWRQISDS DRERLSSKAE DGEFWMSFSD FMRHYSRVEI CNLTPDALTD
360 370 380 390 400
ESVNKWALSK FDGNWRNGST AGGCRNYPNS FWMNPQFLIK LEEQDDDPTD
410 420 430 440 450
NEAGCSFVVG LIQKNRRKMR KVGEDMNTIG FAIYEVPDEF VGQRNVHLDR
460 470 480 490 500
NFFVRHASAA RSETFINLRE VCSRFCLPPG EYLIVPSTFE PNKDGDFCVR
510 520 530 540 550
VFSEKQAEFQ ELDDPVESKV AEIEIKEGDI DSRFRNLFKQ LAGADSEISA
560 570 580 590 600
FELQKILNNV IAKRKDIKTD GFSLETCRNM VNLLDKDGTG KLGLLEFKIL
610 620 630 640 650
WTKIELFVDV YSKNDKDQSG TMSSMEMREA VEKAGFSLNN ALHQILVARY
660 670 680 690 700
SEPNLTIDFD NFVACLIRLE CMFKAFKVLD KDKNGTVELN MMEWLNVSML
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC093295 mRNA Translation: AAH93295.1 |
RefSeqi | NP_001017807.1, NM_001017807.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC093295 mRNA Translation: AAH93295.1 |
RefSeqi | NP_001017807.1, NM_001017807.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000077786 |
Protein family/group databases
MEROPSi | C02.002 |
Organism-specific databases
ZFINi | ZDB-GENE-050417-341, capn2l |
Phylogenomic databases
eggNOGi | KOG0045, Eukaryota |
HOGENOMi | CLU_010982_0_1_1 |
OMAi | MQKLIRI |
TreeFami | TF314748 |
Gene expression databases
Bgeei | ENSDARG00000034211, Expressed in caudal fin and 28 other tissues |
Family and domain databases
CDDi | cd00214, Calpain_III, 1 hit cd00044, CysPc, 1 hit |
InterProi | View protein in InterPro IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR029539, CAPN2 IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR001300, Peptidase_C2_calpain_cat |
PANTHERi | PTHR10183:SF268, PTHR10183:SF268, 1 hit |
Pfami | View protein in Pfam PF01067, Calpain_III, 1 hit PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00720, calpain_III, 1 hit SM00230, CysPc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49758, SSF49758, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50203, CALPAIN_CAT, 1 hit PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS00139, THIOL_PROTEASE_CYS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q561U0_DANRE | |
Accessioni | Q561U0Primary (citable) accession number: Q561U0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |