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Entry version 133 (18 Sep 2019)
Sequence version 2 (05 Dec 2001)
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Protein

UDP-glucose 4-epimerase

Gene

galE

Organism
Salmonella typhi
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei99NADBy similarity1
Binding sitei124NADBy similarity1
Binding sitei124SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei149Proton acceptorBy similarity1
Binding sitei149NADBy similarity1
Binding sitei149SubstrateBy similarity1
Binding sitei153NADBy similarity1
Binding sitei178NAD; via carbonyl oxygenBy similarity1
Binding sitei179SubstrateBy similarity1
Binding sitei231SubstrateBy similarity1
Binding sitei299SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi11 – 12NADBy similarity2
Nucleotide bindingi31 – 36NADBy similarity6
Nucleotide bindingi58 – 59NADBy similarity2
Nucleotide bindingi80 – 84NADBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Galactose metabolism
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001048035:AC754_RS17110-MONOMER
GCF_001048375:AC768_RS08635-MONOMER
GCF_001079465:ADV44_RS14885-MONOMER
GCF_001088345:AEZ18_RS10010-MONOMER
GCF_001095585:AD238_RS09005-MONOMER
GCF_001104165:AE704_RS08630-MONOMER
GCF_001104885:AEZ38_RS09360-MONOMER
GCF_001106745:AE121_RS14900-MONOMER
GCF_001118185:AE086_RS16050-MONOMER
GCF_001119245:AE140_RS15950-MONOMER
GCF_001121865:AE338_RS09585-MONOMER
GCF_001127485:AE735_RS16220-MONOMER
GCF_001135805:AEG73_RS08845-MONOMER
GCF_001148125:AEN24_RS13175-MONOMER
GCF_001148305:AEN67_RS17725-MONOMER
GCF_001157245:AER93_RS08865-MONOMER
GCF_001163025:AFA50_RS08625-MONOMER
GCF_001165785:AFA97_RS16035-MONOMER
GCF_001240865:ALC23_RS09895-MONOMER
GCF_001356455:AQJ76_RS08625-MONOMER
GCF_001357935:AQL34_RS04495-MONOMER
GCF_001359015:AQL50_RS04190-MONOMER
GCF_001360555:AQK88_RS08630-MONOMER
GCF_001361075:AQM75_RS15630-MONOMER
GCF_001362095:AQO19_RS16395-MONOMER
GCF_001362135:AQN73_RS10180-MONOMER
GCF_001362175:AQN68_RS08625-MONOMER
GCF_001362195:AQN87_RS21375-MONOMER
GCF_001362335:AQN99_RS17710-MONOMER
GCF_001364695:AQQ97_RS04800-MONOMER
GCF_900185485:CDZ80_RS15275-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00214

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucose 4-epimerase (EC:5.1.3.2)
Alternative name(s):
Galactowaldenase
UDP-galactose 4-epimerase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:galE
Ordered Locus Names:STY0809, t2111
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri90370 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002670 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001832171 – 338UDP-glucose 4-epimeraseAdd BLAST338

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q56093

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
220341.16501994

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q56093

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni199 – 200Substrate bindingBy similarity2
Regioni216 – 218Substrate bindingBy similarity3
Regioni292 – 295Substrate bindingBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CMR Bacteria
COG1087 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168001

KEGG Orthology (KO)

More...
KOi
K01784

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05247 UDP_G4E_1_SDR_e, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR005886 UDP_G4E

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01179 galE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q56093-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLVTGGSG YIGSHTCVQL LQNGHDVVIL DNLCNSKRSV LPVIERLGGK
60 70 80 90 100
HPTFVEGDIR NEALITEILH DHAIDTVIHF AGLKAVGESV AKPLEYYDNN
110 120 130 140 150
VNGTLRLVSA MRAANVKNLI FSSSATVYGD QPKIPYVESF PTGTPQSPYG
160 170 180 190 200
KSKLMVEQIL TDLQKAQPEW SIALLRYFNP VGAHPSGDMG EDPQGIPNNL
210 220 230 240 250
MPYIAQVAVG RRESLAVFGN DYPTEDGTGV RDYIHVMDLA DGHVVAMEKL
260 270 280 290 300
ADKSGVHIYN LGAGVGSSVL DVVNAFSKAC GKPINYHFAP RRDGDLPAYW
310 320 330
ADASKADREL NWRVTRTLDE MAQDTWHWQS RHPQGYSD
Length:338
Mass (Da):37,096
Last modified:December 5, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F25FE2F0B3D5ADB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti335G → A in CAA58779 (PubMed:7551062).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X83927 Genomic DNA Translation: CAA58779.1
AL513382 Genomic DNA Translation: CAD05224.1
AE014613 Genomic DNA Translation: AAO69728.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51328

NCBI Reference Sequences

More...
RefSeqi
NP_455318.1, NC_003198.1
WP_001265456.1, NZ_UFRG01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAO69728; AAO69728; t2111
CAD05224; CAD05224; CAD05224

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1247256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stt:t2111
sty:STY0809

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|220341.7.peg.813

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83927 Genomic DNA Translation: CAA58779.1
AL513382 Genomic DNA Translation: CAD05224.1
AE014613 Genomic DNA Translation: AAO69728.1
PIRiS51328
RefSeqiNP_455318.1, NC_003198.1
WP_001265456.1, NZ_UFRG01000003.1

3D structure databases

SMRiQ56093
ModBaseiSearch...

Protein-protein interaction databases

STRINGi220341.16501994

Proteomic databases

PRIDEiQ56093

Genome annotation databases

EnsemblBacteriaiAAO69728; AAO69728; t2111
CAD05224; CAD05224; CAD05224
GeneIDi1247256
KEGGistt:t2111
sty:STY0809
PATRICifig|220341.7.peg.813

Phylogenomic databases

eggNOGiENOG4105CMR Bacteria
COG1087 LUCA
HOGENOMiHOG000168001
KOiK01784

Enzyme and pathway databases

UniPathwayiUPA00214
BioCyciGCF_001048035:AC754_RS17110-MONOMER
GCF_001048375:AC768_RS08635-MONOMER
GCF_001079465:ADV44_RS14885-MONOMER
GCF_001088345:AEZ18_RS10010-MONOMER
GCF_001095585:AD238_RS09005-MONOMER
GCF_001104165:AE704_RS08630-MONOMER
GCF_001104885:AEZ38_RS09360-MONOMER
GCF_001106745:AE121_RS14900-MONOMER
GCF_001118185:AE086_RS16050-MONOMER
GCF_001119245:AE140_RS15950-MONOMER
GCF_001121865:AE338_RS09585-MONOMER
GCF_001127485:AE735_RS16220-MONOMER
GCF_001135805:AEG73_RS08845-MONOMER
GCF_001148125:AEN24_RS13175-MONOMER
GCF_001148305:AEN67_RS17725-MONOMER
GCF_001157245:AER93_RS08865-MONOMER
GCF_001163025:AFA50_RS08625-MONOMER
GCF_001165785:AFA97_RS16035-MONOMER
GCF_001240865:ALC23_RS09895-MONOMER
GCF_001356455:AQJ76_RS08625-MONOMER
GCF_001357935:AQL34_RS04495-MONOMER
GCF_001359015:AQL50_RS04190-MONOMER
GCF_001360555:AQK88_RS08630-MONOMER
GCF_001361075:AQM75_RS15630-MONOMER
GCF_001362095:AQO19_RS16395-MONOMER
GCF_001362135:AQN73_RS10180-MONOMER
GCF_001362175:AQN68_RS08625-MONOMER
GCF_001362195:AQN87_RS21375-MONOMER
GCF_001362335:AQN99_RS17710-MONOMER
GCF_001364695:AQQ97_RS04800-MONOMER
GCF_900185485:CDZ80_RS15275-MONOMER

Family and domain databases

CDDicd05247 UDP_G4E_1_SDR_e, 1 hit
InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR005886 UDP_G4E
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01179 galE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGALE_SALTI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q56093
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 5, 2001
Last modified: September 18, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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